Effect of dantrolene on lipid peroxidation, glutathione and glutathione-dependent enzyme activities in experimental otitis media with effusion in guinea pigs

Human and Experimental Toxicology

Volumn 24, Issue 11, 2005, Pages 567-571

  Ucuncu, H ^a   Taysi, Seyithan ^b   Aktan, B ^a   Buyukokuroglu, M E ^c   Elmastas, M ^d  

^a ATATURK UNIVERSITY   (Turkey)

^b Nenehatun Obstetric and Gynecology Hospital ^*  (Turkey)

^c AFYON KOCATEPE UNIVERSITY   (Turkey)

^d GAZIOSMANPASA UNIVERSITY   (Turkey)

Author keywords

Dantrolene sodium; Glutathione; Malondialdehyde; Otitis media with effusion; Oxidative stress

Indexed keywords

DANTROLENE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; HISTAMINE; MALONALDEHYDE; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ERYTHROCYTE; GUINEA PIG; LIPID PEROXIDATION; MALE; MIDDLE EAR EFFUSION; NONHUMAN; OTITIS; OXIDATIVE STRESS; PRIORITY JOURNAL;

ANIMALS; DANTROLENE; DISEASE MODELS, ANIMAL; ERYTHROCYTES; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; GUINEA PIGS; HISTAMINE; LIPID PEROXIDATION; MALE; MALONDIALDEHYDE; MUSCLE RELAXANTS, CENTRAL; OTITIS MEDIA WITH EFFUSION; OXIDATIVE STRESS;

ANIMALIA; CAVIA; CAVIA PORCELLUS;

EID: 28444479551     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1191/0960327105ht569oa     Document Type: Article

References (25)

1. Jung TT, Hanson JB. Classification of otitis media and surgical principles. Otolaryngol Clin North Am 1999; 32: 369-83.
2. Ucuncu H, Aktan B, Ozabacigil F, Buyukokuroglu ME, Akyuz M, Altas E. Protective effect of melatonin on experimental otitis media with effusion in guinea pigs. Ann Clin Lab Sci 2004; 34: 341-46.
3. Taysi S, Polat F, Gul M, Sari RA, Bakan E. Lipid peroxidation, some extracellular antioxidants and antioxidant enzymes in serum of patients with rheumatoid arthritis. Rheumatol Int 2002; 21: 200-204.
4. Taysi S, Gul M, Sari RA, Akcay F, Bakan N. Serum oxidant/antioxidant status of patients with systemic lupus erythematosus. Clin Chem Lab Med 2002; 40: 684-88.
5. Aktan B, Taysi S, Gumustekin K, Bakan N, Sutbeyaz Y. Evaluation of oxidative stress in erythrocytes of the guinea pigs with experimental otitis media with effusion. Ann Clin Lab Sci 2003; 33: 232-36.
6. Taysi S, Koc M, Buyukokuroglu ME, Altinkaynak K, Sahin YN. Melatonin reduces lipid peroxidation and nitric oxide during irradiation-induced oxidative injury in the rat liver. J Pineal Res 2003; 34: 173-77.
7. Bakan E, Taysi S, Polat MF, Dalga S, Umudum Z, Bakan N et al. Nitric oxide levels and lipid peroxidation in plasma of patients with gastric cancer. Jpn J Clin Oncol 2002; 32: 162-66.
8. Miller RD. Skeletal muscle relaxant. In Katzung BG ed. Basic and clinical pharmacology, fourth edition. Englewood Cliffs NJ: Appleton and Lange, 1989: 323-33.
9. Buyukokuroglu ME, Taysi S, Polat F, Gocer F. Mechanism of the beneficial effect of dantrolene sodium on ethanol-induced acute gastric mucosal injury in rats. Pharmacol Res 2002; 45: 421-25.
10. Buyukokuroglu ME. Anti-inflammatory and antinociceptive properties of dantrolene sodium in rats and mice. Pharmacol Res 2002; 45: 455-60.
11. Buyukokuroglu ME, Gulcin I, Oktay M, Kufrevioglu OI. In vitro antioxidant properties of dantrolene sodium. Pharmacol Res 2001; 44: 491-94.
12. Bast A, Haenen GR, Doelman CJ. Oxidant and anti-oxidant: state of the art. Am J Med 1991; 91: 2S-13.
13. Boisvert P, Wasserman SI, Schiff M, Ryan AF. Histamine-induced middle ear effusion and mucosal histopathology in the guinea pigs. Ann Otol Rhinol Laryngol 1985; 94: 212-16.
14. Paglia DE, Valentina WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 1967; 70: 158-69.
15. Pinto RE, Bartley W. The effect of age and sex on glutathione reductase and glutathione peroxidase activities and on aerobic glutathione oxidation in rat liver homogenates. Biochem J 1969; 112: 109-15.
16. Sen CK, Marin E, Kretzschmar M, Hanninen O. Skeletal muscle and liver glutathione homeostasis in response to training, exercise, and immobilization. J Appl Physiol 1992; 73: 1265-72.
17. Fairbanks VF, Klee GG. Biochemical aspects of hematology. In Burtis CA, Ashwood ER eds. Tietz textbook of clinical chemistry. Philadelphia: WB Saunders Co., 1999: 1990-2106.
18. Jain SK, McVie R, Duett J, Herbst JJ. Erythrocyte membrane lipid peroxidation and glycocylated hemoglobin in diabetes. Diabetes 1989; 38: 1539-43.
19. Sigemi H, Kurono Y, Egashira T, Mogi G. Role of super-oxide dismutase in otitis media with effusion. Ann Otol Rhinol Laryngol 1998; 107: 327-31.
20. Takoudes TG, Haddad J. Lipid peroxides in middle ear fluid after acute otitis media in guinea pigs. Ann Otol Rhinol Laryngol 1999; 108: 564-68.
21. Buyukokuroglu ME, Taysi S, Koc M, Bakan N. Dantrolene protects erythrocytes against oxidative stress during whole-body irradiation. Cell Biochem Funct 2002; 21: 127-31.
22. Parks RR, Huang CC, Haddad J. Evidence of oxygen radical injury in experimental otitis media. Laryngoscope 1994; 104: 1389-92.
23. Takoudes TG, Haddad J. Lipid peroxides in middle ear fluid after acute otitis media in guinea pigs. Ann Otol Rhinol Laryngol 1999; 108: 564-68.
24. Doner F, Delibas N, Doǧru H, Yariktas M, Demirci M. The role of free oxygen radicals in experimental otitis media. J Basic Clin Physiol Pharmacol 2002; 13: 33-40.
25. Buyukokuroglu ME, Taysi S, Buyukavci M, Bakan E. Prevention of acute adriamycin cardiotoxicity by dantrolene in rats. Hum Exp Toxicol 2004; 23: 251-56.