Mechanism of the beneficial effects of dantrolene sodium on ethanol-induced acute gastric mucosal injury in rats

Pharmacological Research

Volumn 45, Issue 5, 2002, Pages 421-425

  Büyükokuroǧlu, Mehmet Emin ^a   Taysi, Seyithan ^b   Polat, Fevzi ^a   Göçer, Fatma ^a  

^a ATATÜRK UNIVERSITY   (Turkey)

^b ATATURK UNIVERSITY   (Turkey)

Author keywords

Antioxidant; Dantrolene sodium; Ethanol; Rat; Ulcer

Indexed keywords

ALCOHOL; ANTIOXIDANT; ANTIULCER AGENT; DANTROLENE; FAMOTIDINE; GLUTATHIONE PEROXIDASE; MALONALDEHYDE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; ENZYME ACTIVITY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STOMACH MUCOSA INJURY;

EID: 0036426418     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1006/phrs.2002.0951     Document Type: Article

References (30)

1. Halliwell B, Gutteridge JMC, Cross CE. Free radicals, antioxidants, and human disease: where are we now. J Lab Clin Med 1992; 119: 598-620.
2. El-Habit OH, Saada HN, Azab KS, Abdel-Rahman M, El-Malah DF. The modifying effect of β-carotene on gamma radiation-induced elevation of oxidative reactions and genotoxicity in male rats. Mutat Res 2000; 466: 179-86.
3. Cho CH, Pfeiffer CJ, Misra HP. Ulcerogenic mechanism of ethanol and the activation of sulphanilyl on the rat stomach in vivo. J Pharm Pharmacol 1991; 43: 495-8.
4. Lutnicki K, Wrobel J, Ledwozyw A, Trebas-Pietras E. The effect of calcium ions on the intensity of peroxidation processes and the severity of ethanol-induced injury to the rat's gastric mucosa. Arch Vet Pol 1992; 32: 125-32.
5. Bast A, Haenen GRMM, Doelman CJA. Oxidant and antioxidant: state of the art. Am J Med 1991; 91(Suppl. 3C): 2S-13S.
6. 2+ on endotoxin-sensitivity by galactosamine challenge: Lipid peroxide formation and hepatotoxicity in zymosan-primed mice. Pharmacol Toxicol 1995; 77: 81-6.
7. 2+: Effect of coenzyme Q redox state. Free Radic Biol Med 1995; 18: 55-9.
8. Halliwell B. Reactive oxygen species in living systems: Source, biochemistry, and role in human disease. Am J Med 1991; 91(Suppl. 3C): 14C-22C.
9. Miller RD. Skeletal muscle relaxant. In: Basic and Clinical Pharmacology. Katzung BG, ed. USA: Appleton and Lange, 1989: 323-33.
10. Kayaalp SO. Rasyonel Tedavi Yönünden Tibbi Farmakoloji. 9th Edn, Ankara: Hacettepe-Taş Kitapçilik, 2000: 822-7 (in Turkish).
11. + in ileal longitudinal smooth muscle. Gen Pharmacol 1996; 27: 513-7.
12. 2+ in ileal longitudinal muscle. Gen Pharmacol 1995; 26: 1591-6.
13. Wei H, Perry DC. Dantrolene is cytoprotective in two models of neuronal cell death. J Neurochem 1996; 67: 2390-8.
14. Yamagishi F, Komoda T, Ohnishi K, Itoh S. Protective effect of dantrolene sodium on carbon tetrachloride induced liver injury in the rat. Res Commun Chem Pathol Pharmacol 1993; 82: 237-40.
15. Gepdiremen A, Düzenli S, Hacimüftüoglu A, Süleyman H, Öztaş S. The effects of dantrolene alone or combination with nimodipine in glutamate-induced neurotoxicity in cerebellar granular cell cultures of rat pups. Pharmacol Res 2001; 43: 241-4.
16. Sun Y, Oberley LW, Li Y. A simple method for clinical assay of superoxide dismutase. Clin Chem 1988; 34: 497-500.
17. Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 1967; 70: 158-69.
18. Ohkawa H, Ohishi N, Yagi K. Reaction of linoleic acid hydroperoxide with thiobarbituric acid. J Lipid Res 1978; 19: 1053-7.
19. Lowry O, Roscnbraugh N, Farr L, Randall R. Protein measurement with folin phenol reagent. J Biol Chem 1951; 182: 265-75.
20. Pihan G, Regillo C, Szabo S. Free radicals and lipid peroxidation in ethanol- or aspirin-induced gastric mucosal damage in rats. Dig Dis Sci 1987; 32: 1395-401.
21. Szelenyi I, Brune K. Possible role of oxygen free radicals in ethanol-induced gastric mucosal damage in rats. Dig Dis Sci 1988; 33: 865-71.
22. Brzozowski T, Konturek PC, Konturek SJ, Pajdo R, Bielanski W, Brzozowska I, Stachura J, Hahn EG. The role of melatonin and L-tryptophan in prevention of acute gastric lesions induced by stress, ethanol, ischemia, and aspirin. J Pineal Res 1997; 23: 79-89.
23. Alarcon de la Lastra C, Motilva V, Martin MJ, Nieto A, Barranco MD, Cabeza J, Herrerias JM. Protective effect of melatonin on indomethacin-induced gastric injury in rats. J Pineal Res 1999; 26: 101-7.
24. Gorowara S, Sapru S, Ganguly NK. Role of intracellular second messengers and reactive oxygen species in the pathophysiology of V. Cholera O139 treated rabbit ileum. Biochim Biophys Acta 1998; 1407: 21-30.
25. Yu Z, Luo H, Fu W, Mattson MP. The endoplasmic reticulum stress-responsive protein GRP78 protects neurons against excitotoxicity and apoptosis: Suppression of oxidative stress and stabilization of calcium homeostasis. Exp Neurol 1999; 155: 302-14.
26. Suzuki Y, Ishihara M, Segami T, Ito M. Anti-ulcer effects of antioxidants, quercetin, alpha-tocopherol, nifedipine and tetracycline in rats. Jpn J Pharmacol 1998; 78: 435-41.
27. Alican I, Toker F, Arbak S, Yegen BC, Yalcin AS, Oktay S. Gastric lipid peroxidation, glutathione and calcium channel blockers in the stress-induced ulcer model in rats. Pharmacol Res 1994; 30: 123-35.
28. La Casa C, Villegas I, Alarcon de la Lastra C, Motilva M, Martin Calero MJ. Evidence for protective and antioxidant properties of rutin, a natural flavone, against ethanol induced gastric lesions. J Ethnopharmacol 2000; 71: 45-53.
29. Süleyman H, Büyükokuroǧlu ME, Gepdiremen A. Verapamil, diltiazem, nifedipine and dantrolene versus famotidine in prevention of ethanol-induced gastric ulcers in rats. Int Med J 2000; 7: 139-44.
30. Büyükokuroǧlu ME, Gülçin I, Oktay M, Küfrevioglu Ö.I. In vitro antioxidant properties of dantrolene sodium. Pharmacol Res 2001; 44: 491-4.