Effects of chlorpromazine on mechanical properties of the outer hair cell plasma membrane

Biophysical Journal

Volumn 89, Issue 6, 2005, Pages 4090-4095

  Murdock, David R ^a   Ermilov, Sergey A ^a   Spector, Alexander A ^b   Popel, Aleksander S ^b   Brownell, William E ^c   Anvari, Bahman ^a  

^a Rice University   (United States)

^b Johns Hopkins University   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORPROMAZINE;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CELL MOTILITY; CELL STRUCTURE; CONTROLLED STUDY; CYTOSKELETON; DRUG EFFECT; FEMALE; FORCE; HAIR CELL; MALE; MODEL; NONHUMAN; RIGIDITY; VISCOELASTICITY; VISCOSITY;

ANIMALIA; MAMMALIA;

EID: 28444448080     PISSN: 00063495     EISSN: 00063495     Source Type: Journal    
DOI: 10.1529/biophysj.105.069872     Document Type: Article

References (33)

1. Brownell, W. E. 1984. Microscopic observation of cochlear hair cell motility. Scan. Electron Microsc. Part 3:1401-1406.
2. Liberman, M. C., J. Gao, D. Z. He, X. Wu, S. Jia, and J. Zuo. 2002. Prestin is required for electromotility of the outer hair cell and for the cochlear amplifier. Nature. 419:300-304.
3. Brownell, W. E., C. R. Bader, D. Bertrand, and Y. de Ribaupierre. 1985. Evoked mechanical responses of isolated cochlear outer hair cells. Science. 227:194-196.
4. Dallos, P., and M. E. Corey. 1991. The role of outer hair cell motility in cochlear tuning. Curr. Opin. Neurobiol. 1:215-220.
5. Davis, H. 1983. An active process in cochlear mechanics. Hear. Res. 9:79-90.
6. Spector, A. A. 1999. Nonlinear electroelastic model for the composite outer hair cell wall. ORL J. Otorhinolatyngol. Relat. Spec. 61:287-293.
7. Spector, A. A., M. Ameen, and A. S. Popel. 2001. Simulation of motor-driven cochlear outer hair cell electromotility. Biophys. J. 81:11-24.
8. Spector, A. A., W. E. Brownell, and A. S. Popel. 1998. Elastic properties of the composite outer hair cell wall. Ann. Biomed. Eng. 26:157-165.
9. Lue, A. J., H. B. Zhao, and W. E. Brownell. 2001. Chlorpromazine alters outer hair cell electromotility. Otolaryngol. Head Neck Surg. 125:71-76.
10. Oghalai, J. S. 2004. Chlorpromazine inhibits cochlear function in guinea pigs. Hear. Res. 198:59-68.
11. Sheetz, M. P., and S. J. Singer. 1976. Equilibrium and kinetic effects of drugs on the shapes of human erythrocytes. J. Cell Biol. 70:247-251.
12. Hueck, I. S., H. G. Hollweg, G. W. Schmid-Schonbein, and G. M. Artmann. 2000. Chlorpromazine modulates the morphological macro- and microstructure of endothelial cells. Am. J. Physiol. Cell Physiol. 278:C873-C878.
13. Jutila, A., T. Soderlund, A. L. Pakkanen, M. Huttunen, and P. K. Kinnunen. 2001. Comparison of the effects of clozapine, chlorpromazine, and haloperidol on membrane lateral heterogeneity. Chem. Phys. Lipids. 112:151-163.
14. Hochmuth, R. M., and E. A. Evans. 1982. Extensional flow of erythrocyte membrane from cell body to elastic tether. I. Analysis. Biophys. J. 39:71-81.
15. Hochmuth, R. M., H. C. Wiles, E. A. Evans, and J. T. McCown. 1982. Extensional flow of erythrocyte membrane from cell body to elastic tether. II. Experiment. Biophys. J. 39:83-89.
16. Waugh, R. E., and R. M. Hochmuth. 1987. Mechanical equilibrium of thick, hollow, liquid membrane cylinders. Biophys. J. 52:391-400.
17. Dai, J., and M. P. Sheetz. 1995. Mechanical properties of neuronal growth cone membranes studied by tether formation with laser optical tweezers. Biophys. J. 68:988-996.
18. Li, Z., B. Anvari, M. Takashima, P. Brecht, J. H. Torres, and W. E. Brownell. 2002. Membrane tether formation from outer hair cells with optical tweezers. Biophys. J. 82:1386-1395.
19. Sleep, J., D. Wilson, R. Simmons, and W. Gratzer. 1999. Elasticity of the red cell membrane and its relation to hemolytic disorders: an optical tweezers study. Biophys. J. 77:3085-3095.
20. Ermilov, S., and B. Anvari. 2004. Dynamic measurements of transverse optical trapping force in biological applications. Ann. Biomed. Eng. 32:1016-1026.
21. Oghalai, J. S., H. B. Zhao, J. W. Kutz, and W. E. Brownell. 2000. Voltage- and tension-dependent lipid mobility in the outer hair cell plasma membrane. Science. 287:658-661.
22. Fung, Y. C. 1993. Biomechanics: Mechanical Properties of Living Tissues. Springer-Verlag, New York.
23. Dan, N., and S. A. Safran. 1998. Effect of lipid characteristics on the structure of transmembrane proteins. Biophys. J. 75:1410-1414.
24. Lundbaek, J. A., A. M. Maer, and O. S. Andersen. 1997. Lipid bilayer electrostatic energy, curvature stress, and assembly of gramicidin channels. Biochemistry. 36:5695-5701.
25. Raphael, R. M., R. E. Waugh, S. Svetina, and B. Zeks. 2001. Fractional occurrence of defects in membranes and mechanically driven interleaflet phospholipid transport. Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 64:051913.
26. Rothman, J. E., and E. A. Dawidowicz. 1975. Asymmetric exchange of vesicle phospholipids catalyzed by the phosphatidylcholine exchange protein. Measurement of inside-outside transitions. Biochemistry. 14:2809-2816.
27. Raphael, R. M., and R. E. Waugh. 1996. Accelerated interleaflet transport of phosphatidylcholine molecules in membranes under deformation. Biophys. J. 71:1374-1388.
28. Waugh, R. E., and R. G. Bauserman. 1995. Physical measurements of bilayer-skeletal separation forces. Ann. Biomed. Eng. 23:308-321.
29. Morimoto, N., R. M. Raphael, A. Nygren, and W. E. Brownell. 2002. Excess plasma membrane and effects of ionic amphipaths on mechanics of outer hair cell lateral wall. Am. J. Physiol. Cell Physiol. 282:C1076-C1086.
30. Brownell, W. E., A. A. Spector, R. M. Raphael, and A. S. Popel. 2001. Micro- and nanomechanics of the cochlear outer hair cell. Annu. Rev. Biomed. Eng. 3:169-194.
31. Spector, A. A., W. E. Brownell, and A. S. Popel. 1999. Nonlinear active force generation by cochlear outer hair cell. J. Acoust. Soc. Am. 105:2414-2420.
32. Ulfendahl, M., E. Chan, W. B. McConnaughey, S. Prost-Domasky, and E. L. Elson. 1998. Axial and transverse stiffness measures of cochlear outer hair cells suggest a common mechanical basis. Pflugers Arch. 436:9-15.
33. Qian, F., S. Ermilov, D. R. Murdock, W. E. Brownell, and B. Anvari. 2004. Combining optical tweezers and patch clamp for studies of cell membranes. Rev. Sci. Instrum. 75:2937-2943.