Enantioselective protonation of catalytically generated chiral enolates as an approach to the synthesis of α-chloroesters

Journal of the American Chemical Society

Volumn 127, Issue 47, 2005, Pages 16406-16407

  Reynolds, Nathan T ^a   Rovis, Tomislav ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CHLOROESTER DERIVATIVE; ESTER DERIVATIVE; PHENOL DERIVATIVE; UNCLASSIFIED DRUG;

ACYLATION; ARTICLE; CATALYSIS; CHIRALITY; ENANTIOSELECTIVITY; PROTON TRANSPORT; STEREOCHEMISTRY; SYNTHESIS;

CATALYSIS; CHLORINE; ESTERS; MOLECULAR STRUCTURE; PROTONS; STEREOISOMERISM;

EID: 28444444128     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja055918a     Document Type: Article

References (34)

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34. Under the reported conditions, using 5 mol % of A (1.42 g) and 1a (60 mmol) provided 8.67 g of 2a (55% yield) with 90% ee (62% recovery of excess PhOH).