Restoring retinal function in a mouse model of hereditary blindness

PLoS Medicine

Volumn 2, Issue 11, 2005, Pages 1088-1089

  Moore, Tony ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; LECITHIN RETINOL ACYLTRANSFERASE; RETINOID DERIVATIVE; RETINOID ISOMERASE; UNCLASSIFIED DRUG; VISUAL PIGMENT;

CLINICAL RESEARCH; CONGENITAL BLINDNESS; DRUG RESEARCH; ENZYME SYNTHESIS; LEBER CONGENITAL AMAUROSIS; NONHUMAN; PHOTORECEPTOR POTENTIAL; RETINA DYSTROPHY; SHORT SURVEY; TREATMENT OUTCOME; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; VISUAL FIELD; ANIMAL; BLINDNESS; DISEASE MODEL; GENETICS; LEBER HEREDITARY OPTIC NEUROPATHY; MOUSE; MOUSE MUTANT; NOTE; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY; PATIENT SELECTION;

ANIMALS; BLINDNESS; DISEASE MODELS, ANIMAL; DNA MUTATIONAL ANALYSIS; MICE; MICE, KNOCKOUT; OPTIC ATROPHY, HEREDITARY, LEBER; PATIENT SELECTION;

EID: 28444440299     PISSN: 15491277     EISSN: 15491676     Source Type: Journal    
DOI: 10.1371/journal.pmed.0020399     Document Type: Short Survey

References (4)

1. Rahi JS, Cable N (2003) Severe visual impairment and blindness in children in the UK. Lancet 362: 1359-1365.
2. Batten ML, Imanishi Y, Tu DC, Doan T, Zhu L, et al (2005) Pharmacological and rAAV gene therapy rescue of visual functions in a blind mouse model of Leber congenital amaurosis. PLoS Med 2: e333. DOI: 10.1371/journal.pmed.0020333
3. Acland GM, Aguirre GD, Ray J, Zhang Q, Aleman TS, et al. (2001) Gene therapy restores vision in a canine model of childhood blindness. Nat Genet 28: 92-95.
4. Sparrow JR (2003) Therapy for macular degeneration: Insights from acne. Proc Natl Acad Sci U S A 100: 4353-4354.