Efficient synthesis of 6-amino-substituted pyridin-2(1H)-ones using in situ generated propiolic acid chloride

Synthesis

Volumn , Issue 18, 2005, Pages 3085-3094

  Schirok, Hartmut ^a   Alonso Alija, Cristina ^a   Michels, Martin ^a  

^a BAYER PHARMA AG   (Germany)

Author keywords

Cyclizations; N,S acetals; Pyridin 2(1H) ones; Ring closure; Thioacetals

Indexed keywords

AMINO ACIDS; CHLORIDE MINERALS; SUBSTITUTION REACTIONS; SYNTHESIS (CHEMICAL);

CYCLIZATION; N,S-ACETALS; PYRIDIN-2(1H) ONES; RING CLOSURE; THIOACETALS;

KETONES;

1 CYCLOPROPYL 6 [(CYCLOPROPYLMETHYL)AMINO] 5 (4 FLUOROBENZOYL)PYRIDIN 2(1H) ONE; 3 (CYCLOHEXYLAMINO) 3 (ETHYLTHIO) 1 (4 FLUOROPHENYL)PROP 2 EN 1 ONE; 3 (ETHYLTHIO) 1 (4 FLUOROPHENYL) 3 [(4 FLUOROPHENYL)AMINO]PROP 2 EN 1 ONE; 3 (ETHYLTHIO) 3 (METHYLAMINO) 1 PHENYLPROP 2 EN 1 ONE; 3 ANILINO 3 (ETHYLTHIO) 1 (4 FLUOROPHENYL)PROP 2 EN 1 ONE; 3 ANILINO 3 (ETHYLTHIO) 1 PHENYLPROP 2 EN 1 ONE; 5 (4 FLUOROBENZOYL) 1 (4 FLUOROPHENYL) 6 [(2 HYDROXYETHYL)AMINO]PYRIDIN 2(1H) ONE; 5 (4 FLUOROBENZOYL) 1 (4 FLUOROPHENYL) 6 [(3 FURYLMETHYL)AMINO]PYRIDIN 2(1H) ONE; 5 (4 FLUOROBENZOYL) 6 [(2 FURYLMETHYL)AMINO] 1 ISOBUTYLPYRIDIN 2(1H) ONE; 5 (4 FLUOROBENZOYL) 6 [(4 HYDROXYCYCLOHEXYL)AMINO] 1 PHENYLPYRIDIN 2(1H) ONE; 5 BENZOYL 1 METHYL 6 [(PYRIDIN 3 YLMETHYL)AMINO]PYRIDIN 2(1H) ONE; 5 BENZOYL 1 PHENYL 6 [(2 THIENYLMETHYL)AMINO]PYRIDIN 2(1H) ONE; 5 BENZOYL 6 (CYCLOHEXYLAMINO) 1 PHENYLPYRIDIN 2(1H) ONE; 5 BENZOYL 6 (ETHYLAMINO) 1 METHYLPYRIDIN 2(1H) ONE; 5 BENZOYL 6 (ETHYLSULFINYL) 1 PHENYLPYRIDIN 2(1H) ONE; 5 BENZOYL 6 (ETHYLTHIO) 1 PHENYLPYRIDIN 2(1H) ONE; 5 BENZOYL 6 (ISOBUTYLAMINO) 1 PHENYLPYRIDIN 2(1H) ONE; 5 BENZOYL 6 (TERT BUTYLAMINO) 1 METHYLPYRIDIN 2(1H) ONE; 5 BENZOYL 6 [(2 METHOXYETHYL)AMINO] 1 METHYLPYRIDIN 2(1H) ONE; 6 (BENZYLAMINO) 1 CYCLOHEXYL 5 (4 FLUOROBENZOYL)PYRIDIN 2(1H) ONE; 6 (CYCLOBUTYLAMINO) 5 (4 FLUOROBENZOYL) 1 (2 METHOXYETHYL)PYRIDIN 2(1H) ONE; 6 (CYCLOHEXYLAMINO) 5 (4 FLUOROBENZOYL) 1 ISOBUTYLPYRIDIN 2(1H) ONE; 6 (CYCLOPROPYLAMINO) 5 (4 FLUOROBENZOYL) 1 (2 PHENYLETHYL)PYRIDIN 2(1H) ONE; 6 ANILINO 5 BENZOYL 1 METHYLPYRIDIN 2(1H) ONE; ACID; AMINE; ETHYL 4 [(3 BENZOYL 1 METHYL 6 OXO 1,6 DIHYDROPYRIDIN 2 YL)AMINO]PIPERIDINE 1 CARBOXYLATE; PROPIOLIC ACID CHLORIDE; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; CYCLIZATION; STEREOCHEMISTRY; SYNTHESIS;

EID: 28344456112     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2005-872217     Document Type: Article

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