Tubular transporters OAT1 and MRP2 and clearance of adefovir;Effet de l'inhibition des transporteurs OAT1 et MRP2 sur la clairance de l'adéfovir

Nephrologie et Therapeutique

Volumn 1, Issue 5, 2005, Pages 296-300

  Servais, Aude ^a,b   Lechat, Philippe ^a   Zahr, Noël ^a   Urien, Saik ^a   Aymard, Guy ^a   Jaudon, Marie Chantal ^a   Deray, Gilbert ^a   Bagnis, Corinne Isnard ^a  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^b HÔPITAL NECKER ENFANTS MALADES   (France)

Author keywords

Adefovir clearance; NONMEM; Organic anion transporter; Probenecid; TR rats

Indexed keywords

ADEFOVIR; MULTIDRUG RESISTANCE PROTEIN 2; ORGANIC ANION TRANSPORTER; PLACEBO; PROBENECID;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG ELIMINATION; DRUG EXCRETION; DRUG TRANSPORT; DRUG URINE LEVEL; GENE MUTATION; IN VIVO STUDY; NONHUMAN; POPULATION MODEL; PROTEIN FUNCTION; RAT; URINARY EXCRETION;

EID: 28344452208     PISSN: 17697255     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nephro.2005.06.011     Document Type: Article

References (10)

1. Squires KE. An introduction to nucleoside and nucleotide analogues. Antiviral Ther 2001;6(suppl 3):1-14.
2. Mizuno N, Niwa T, Yotsumoto Y, Sugiyama Y. Impact of drug transporter studies on drug discovery and development. Pharmacol Rev 2003;55:425-61.
3. Russel F, Masereeuw R, Van Aubel R. Molecular aspects of renal anionic drug transport. Ann Rev Physiol 2002;64:563-94.
4. Lacy S, Hitchcock M, Lee W, Tellier P, Cundy K. Effect of oral probenecid coadministration on the chronic toxicity and pharmacokinetics of intravenous cidofovir in cynomolgus monkeys. Toxicol Sci 1998;44:97-106.
5. Masereeuw R, Notenboom S, Smeets PH, Wouterse AC, Russel FG. Impaired renal secretion of substrates for the multidrug resistance protein 2 in mutant transport-deficient (TR-) rats. J Am Soc Nephrol 2003;14:2741-9.
6. Cundy KC, Barditch-Crovo P, Walker RE, Collier AC, Ebeling D, Toole J, et al. Clinical pharmacokinetics of adefovir in human immunodeficiency virus type 1-infected patients. Antimicrob Agents Chemother 1995;39:2401-5.
7. Merta A, Votruba I, Jindrich J, Holy A, Cihlar T, Rosenberg I, et al. Phosphorylation of 9-(2-phosphonomethoxyethyl)adenine and 9-(5)-(3-hydroxy-2- phosphonomethoxypropyl)adenine by AMP(dAMP) kinase from L1210 cells. Biochem Pharmacol 1992;44:2067-77.
8. Qaqish RB, Mattes KA, Ritchie DJ. Adefovir dipivoxil: a new antiviral agent for the treatment of hepatitis B virus infection. Clin Ther 2003;25:3084-99.
9. Cundy KC. Clinical pharmacokinetics of the antiviral nucleotide analogues cidofovir and adefovir. Clin Pharmacokinet 1999;36:127-43.
10. Van Aubel RA, Masereeuw R, Russel FG. Molecular pharmacology of renal organic anion transporters. Am J Physiol Ren Physiol 2000;279:F216-F232.