MCT-1 oncogene contributes to increased in vivo tumorigenicity of MCF7 cells by promotion of angiogenesis and inhibition of apoptosis

Cancer Research

Volumn 65, Issue 23, 2005, Pages 10651-10656

  Levenson, Anait S ^a   Thurn, Kenneth E ^a   Simons, Laura A ^a   Veliceasa, Dorina ^a   Jarrett, Jennifer ^a   Osipo, Clodia ^a   Craig Jordan, V ^a,b   Volpert, Olga V ^a   Satcher Jr , Robert L ^a   Gartenhaus, Ronald B ^c,d  

^a NORTHWESTERN UNIVERSITY   (United States)

^b FOX CHASE CANCER CENTER   (United States)

^c UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTER   (United States)

^d UNIVERSITY OF MARYLAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DNA; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; FULVESTRANT; MESSENGER RNA; THROMBOSPONDIN 1; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; CARCINOGENICITY; CELL PROLIFERATION; CELL STRAIN MCF 7; CONTROLLED STUDY; DNA SYNTHESIS; GENE FUNCTION; GENE OVEREXPRESSION; GENE VECTOR; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; MALIGNANT TRANSFORMATION; MCT 1 GENE; MOUSE; NONHUMAN; ONCOGENE; PHENOTYPE; PRIORITY JOURNAL; TUMOR GROWTH;

ANIMALS; APOPTOSIS; BREAST NEOPLASMS; CELL CYCLE PROTEINS; CELL LINE, TUMOR; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; FEMALE; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOVASCULARIZATION, PATHOLOGIC; ONCOGENE PROTEINS; TRANSFECTION;

EID: 28244452916     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-05-0845     Document Type: Article

References (18)

1. Perou CM, Sorlie T, Eisen MB, et al. Molecular portraits of human breast tumours. Nature 2000;406:747-52.
2. Prosniak M, Dierov J, Okami K, et al. A novel candidate oncogene, MCT-1, is involved in cell cycle progression. Cancer Res 1998;58:4233-7.
3. 1 cyclin/cdk activity in cells overcxpressing the candidate oncogene, MCT-1. J Cell Biochem 1999;74:544-50.
4. Hsu HL, Shi B, Gartenhaus RB, The MCT-1 oncogene product impairs cell cycle checkpoint control and transforms human mammary epithelial cells. Oncogene 2005;24:4956-64.
5. Shi B, Hsu HL, Evens AM, Gordon LI, Gartenhaus RB. Expression of the candidate MCT-1 oncogene in B- and T-cell lymphoid malignancies. Blood 2003;102:297-302.
6. Levenson AS, Kwaan HC, Svoboda KM, Weiss IM, Sakurai S, Jordan VC. Estradiol regulation of components of the plasminogen-plasmin system in MDA-MB-231 human breast cancer cells stably expressing the estrogen receptor. Br J Cancer 1998;7:1812-9.
7. Levenson AS, Gehm BD, Timm Pearce S, et al. Resveratrol acts as an estrogen receptor (ER) agonist in breast cancer cells stably transfected with ERα. Int J Cancer 2003;104:587-96.
8. Volpert OV, Dameron KM, Bouck N. Sequential development of an angiogenic phenotype by human fibroblasts progressing to tumorigenicity. Oncogene 1997;14:1495-502.
9. Jiang S-Y, Wolf DM, Yingling JM, Chang C, Jordan VC. An estrogen receptor positive MCF-7 clone that is resistant to antiestrogens and estradiol. Mol Cell Endocrinol 1992;90:77-86.
10. Murphy CS, Pink JJ, Jordan VC. Characterization of a receptor-negative, hormone-nonresponsive clone derived froma T47D human breast cancer cell line kept under estrogen-free conditions. Cancer Res 1990;50:7285-92.
11. Pink JJ, Jordan VC. Models of estrogen receptor regulation by estrogens and antiestrogens in breast cancer cell lines. Cancer Res 1996;56:2321-30.
12. Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996;86:353-64.
13. Reiher FK, Volpert OV, Jimenez B, et al. Inhibition of tumor growth by systemic treatment with thrombospondin-1 peptide mimetics. Int J Cancer 2002;98: 682-9.
14. Carmeliet P, Dor Y, Herbert JM, et al. Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 1998;394:485-90.
15. Jimenez B, Volpert OV. Mechanistic insights on the inhibition of tumor angiogenesis. J Mol Med 2001;78:663-72.
16. Kim LS, Huang S, Lu W, Lev DC, Price JE. Vascular endothelial growth factor expression promotes the growth of breast cancer brain metastases in nude mice. Clin Exp Metastasis 2004;21:107-18.
17. Rice AJ, Steward MA, Quinn CM. Thrombospondin 1 protein expression relates to good prognostic indices in ductal carcinoma in situ of the breast. J Clin Pathol 2002; 55:921-5.
18. Weinstat-Saslow DL, Zabrenetzky VS, VanHoutte K, Frazier WA, Roberts DD. Transfection of trombospondin 1 complementary DNA into a human breast carcinoma cell line reduces primary tumor growth, metastatic potential, and angiogenesis. Cancer Res 1994;54:6504-11.