Identification of the structural requirements of the receptor-binding affinity of diphenolic azoles to estrogen receptors α and β by three-dimensional quantitative structure-activity relationship and structure-activity relationship analysis

Journal of Medicinal Chemistry

Volumn 48, Issue 24, 2005, Pages 7628-7636

  Demyttenaere Kovatcheva, Assia ^a   Cronin, Mark T D ^a   Benfenati, Emilio ^a   Roncaglioni, Alessandra ^b   LoPiparo, Elena ^b  

^a LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

^b MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BENZISOXAZOLE DERIVATIVE; BENZOXAZOLE DERIVATIVE; DIPHENOLIC AZOLE; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ISOXAZOLE DERIVATIVE; NAPHTHYL GROUP; OXAZOLE DERIVATIVE; OXYGEN; PHENYL GROUP; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; COMPARATIVE MOLECULAR FIELD ANALYSIS; DRUG RECEPTOR BINDING; ELECTRICITY; MORPHOMETRICS; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STEREOCHEMISTRY; VALIDATION PROCESS;

AZOLES; BINDING SITES; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHENOLS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 28244446352     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050604j     Document Type: Article

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