Screening new drugs for immunotoxic potential: II. Assessment of the effects of selective and nonselective COX-2 inhibitors on complement activation, superoxide anion production and leukocyte chemotaxis and migration through endothelial cells

Journal of Immunotoxicology

Volumn 2, Issue 2, 2005, Pages 85-96

  Furst, Sylvia M ^a   Khan, K Nasir ^a   Komocsar, Wendy J ^b   Fan, Lian ^b   Mennear, John ^c  

^a PFIZER INC   (United States)

^b ELI LILLY AND COMPANY   (United States)

^c CAMPBELL UNIVERSITY   (United States)

Author keywords

Complement activation; Leukocyte migration; Leupeptin; Phorbol myristate acetate; Selective COX 2 inhibitors; Staurosporine; Superoxide anion; TNF

Indexed keywords

4 [5 (4 CHLOROPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOL 1 YL]BENZENESULFONAMIDE; CYCLOOXYGENASE 2 INHIBITOR; CYTOCHALASIN B; HYDROGEN PEROXIDE; IBUPROFEN; LEUPEPTIN; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; PHORBOL 13 ACETATE 12 MYRISTATE; SC 245; SC 791; STAUROSPORINE; SUPEROXIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; COMPLEMENT ACTIVATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG SCREENING; ENDOTHELIUM CELL; EX VIVO STUDY; FEMALE; HEMOLYSIS; HUMAN; IC 50; IMMUNOMODULATION; IMMUNOTOXICITY; IN VITRO STUDY; INNATE IMMUNITY; LEUKOCYTE MIGRATION; MALE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY BURST; SHEEP ERYTHROCYTE;

ANIMALIA; CANIS FAMILIARIS; MURINAE; OVIS ARIES;

EID: 28244439051     PISSN: 16602854     EISSN: 1547691X     Source Type: Journal    
DOI: 10.1080/15476910591002668     Document Type: Article

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