Family-based association analysis implicates IL-4 in susceptibility to Kawasaki disease

Genes and Immunity

Volumn 6, Issue 5, 2005, Pages 438-444

  Burns, J C ^a   Shimizu, C ^a   Shike, H ^a   Newburger, J W ^b   Sundel, R P ^b   Baker, A L ^b   Matsubara, T ^c   Ishikawa, Y ^c   Brophy, V A ^d   Cheng, S ^d   Grow, M A ^d   Steiner, L L ^d   Kono, N ^e   Cantor, R M ^e  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c YAMAGUCHI UNIVERSITY   (Japan)

^d ROCHE MOLECULAR SYSTEMS   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Coronary artery aneurysm; Pediatrics; Polymorphism; Th2 immune response; Transmission disequilibrium test; Vasculitis

Indexed keywords

COLONY STIMULATING FACTOR; IMMUNOGLOBULIN E; IMMUNOGLOBULIN E RECEPTOR; INTERLEUKIN 13; INTERLEUKIN 4; TRANSCRIPTION FACTOR;

ALLELE; ALLERGY; ARTICLE; ATOPIC DERMATITIS; CARDIOVASCULAR DISEASE; CELL COUNT; CHILD; CLUSTER ANALYSIS; COHORT ANALYSIS; CONTROLLED STUDY; CORONARY ARTERY ANEURYSM; DISEASE PREDISPOSITION; DISEASE TRANSMISSION; EOSINOPHILIA; EVIDENCE BASED MEDICINE; FAMILY HISTORY; FEMALE; GENE CLUSTER; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; HUMAN CELL; IMMUNOGLOBULIN BLOOD LEVEL; INFLAMMATION; MACROPHAGE; MAJOR CLINICAL STUDY; MALE; MONOCYTE; MUCOCUTANEOUS LYMPH NODE SYNDROME; PATHOGENESIS; PRIORITY JOURNAL; VASCULITIS;

CHILD; CHILD, PRESCHOOL; CHROMOSOMES, HUMAN, PAIR 5; COHORT STUDIES; CORONARY ANEURYSM; DERMATITIS, ATOPIC; EOSINOPHILIA; FAMILY; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IMMUNOGLOBULIN E; INTERLEUKIN-4; MACROPHAGES; MALE; MUCOCUTANEOUS LYMPH NODE SYNDROME; RECEPTORS, IGE; VASCULITIS;

EID: 28044468154     PISSN: 14664879     EISSN: 14765470     Source Type: Journal    
DOI: 10.1038/sj.gene.6364225     Document Type: Article

References (59)

1. Kawasaki T, Kosaki F, Okawa S, Shigematsu I, Yanagawa H. A new infantile acute febrile mucocutaneous lymph node syndrome (MLNS) prevailing in Japan. Pediatrics 1974; 54: 271-276.
2. Taubert KA, Rowley AH, Shulman ST. Seven-year national survey of Kawasaki disease and acute rheumatic fever. Pediatr Infect Dis J 1994; 13: 704-708.
3. Kato H, Sugimura T, Akagi T et al. Long-term consequences of Kawasaki disease. A 10- to 21-year follow-up study of 594 patients. Circulation 1996; 94: 1379-1385.
4. Kawasaki T. Acute febrile mucocutaneous syndrome with lymphoid involvement with specific desquamation of the fingers and toes in children. Arerugi 1967; 16: 178-222.
5. Burns JC. Commentary: Translation of Dr Tomisaku Kawasaki's original report of fifty patients in 1967. ArticlePlus. Pediatr Infect Dis J 2002; 21: 993-995.
6. Burns JC, Glode MP. Kawasaki syndrome. Lancet 2004; 364: 533-544.
7. Morens DM, O'Brien RJ. Kawasaki disease in the United States. J Infect Dis 1978; 137: 91-93.
8. Shulman ST, McAuley JB, Pachman LM, Miller ML, Ruschhaupt DG. Risk of coronary abnormalities due to Kawasaki disease in urban area with small Asian population. Am J Dis Child 1987; 141: 420-425.
9. Holman RC, Curns AT, Belay ED, Steiner CA, Schonberger LB. Kawasaki syndrome hospitalizations in the United States, 1997 and 2000. Pediatrics 2003; 112: 495-501.
10. Burns JC, Kushner HI, Bastian JF. Kawasaki disease: A brief history. Pediatrics 2000; 106: E27.
11. Burns JC, Cayan DR, Tong G et al. Seasonality and temporal clustering of Kawasaki Syndrome in Japan, 1987-2000. Epidemiology 2005; 16: 220-225.
12. Bronstein DE, Dille AN, Austin JP, Williams CM, Palinkas LA, Burns JC. Relationship of climate, ethnicity and socioeconomic status to Kawasaki disease in San Diego County, 1994 through 1998. Pediatr Infect Dis 12000; 19: 1087-1091.
13. Hirata S, Nakamura Y, Yanagawa H. Incidence rate of recurrent Kawasaki disease and related risk factors: From the results of nationwide surveys of Kawasaki disease in Japan. Acta Paediatr 2001; 90: 40-44.
14. Uehara R, Yashiro M, Nakamura Y, Yanagawa H. Kawasaki disease in parents and children. Acta Paediatr 2003; 92: 694-697.
15. Takeuchi K, Yamamoto K, Kataoka S et al. High incidence of angiotensin I converting enzyme genotype II in Kawasaki disease patients with coronary aneurysm. Eur J Pediatr 1997; 156: 266-268.
16. Quasney MW, Bronstein DE, Cantor RM et al. Increased frequency of alleles associated with elevated tumor necrosis factor-alpha levels in children with Kawasaki disease. Pediatr Res 2001; 49: 686-690.
17. Ouchi K, Suzuki Y, Shirakawa T, Kishi F. Polymorphism of SLC11A1 (formerly NRAMP1) gene confers susceptibility to Kawasaki disease. J Infect Dis 2003; 187: 326-329.
18. Nishimura S, Zaitsu M, Hara M et al. A polymorphism in the promoter of the CD14 gene (CD14/-159) is associated with the development of coronary artery lesions in patients with Kawasaki disease. J Pediatr 2003; 143: 357-362.
19. Jibiki T, Terai M, Shima M et al. Monocyte chemoattractant protein 1 gene regulatory region polymorphism and serum levels of monocyte chemoattractant protein 1 in Japanese patients with Kawasaki disease. Arthritis Rheum 2001; 44: 2211-2212.
20. Biezeveld MH, Kuipers IM, Geissler J et al. Association of mannose-binding lectin genotype with cardiovascular abnormalities in Kawasaki disease. Lancet 2003; 361: 1268-1270.
21. Onouchi Y, Onoue S, Tamari M et al. CD40 ligand gene and Kawasaki disease. Eur J Hum Genet 2004; 12: 1062-1068.
22. Spielman RS, McGinnis RE, Ewens WJ. Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 1993; 52: 506-516.
23. Daly MJ, Rioux JD, Schaffner SF, Hudson TJ, Lander ES. High-resolution haplotype structure in the human genome. Nat Genet 2001; 29: 229-232.
24. Li-Weber M, Krammer PH. Regulation of IL4 gene expression by T cells and therapeutic perspectives. Nat Rev Immunol 2003; 3: 534-543.
25. Hirao J, Hibi S, Andoh T, Ichimura T. High levels of circulating interleukin-4 and interleukin-10 in Kawasaki disease. Int Arch Allergy Immunol 1997; 112: 152-156.
26. Matsubara T, Katayama K, Matsuoka T, Fujiwara M, Koga M, Furukawa S. Decreased interferon-gamma (IFN-gamma)-producing T cells in patients with acute Kawasaki disease. Clin Exp Immunol 1999; 116: 554-557.
27. Spiegelberg HL. Structure and function of Fc receptors for IgE on lymphocytes, monocytes, and macrophages. Adv Immunol 1984; 35: 61-88.
28. Furukawa S, Matsubara T, Motohashi T et al. Increased expression of Fc epsilon R2/CD23 on peripheral blood B lymphocytes and serum IgE levels in Kawasaki disease. Int Arch Allergy Appl Immunol 1991; 95: 7-12.
29. Furukawa S, Matsubara T, Motohashi T et al. Expression of Fc epsilon R2/ CD23 on peripheral blood macrophages/monocytes in Kawasaki disease. Clin Immunol Immunopathol 1990; 56: 280-286.
30. Matsubara T, Furukawa S, Motohashi T, Okumura K, Yabuta K. Soluble CD23 antigen in Kawasaki disease and other acute febrile illnesses. Eur J Pediatr 1995; 154: 826-829.
31. Nash MC, Shah V, Dillon MJ. Soluble cell adhesion molecules and von Willebrand factor in children with Kawasaki disease. Clin Exp Immunol 1995; 101: 13-17.
32. Takeshita S, Dobashi H, Nakatani K et al. Circulating soluble selectins in Kawasaki disease. Clin Exp Immunol 1997; 108: 446-450.
33. Miura M, Garcia FL, Crawford SE, Rowley AH. Cell adhesion molecule expression in coronary artery aneurysms in acute Kawasaki disease. Pediatr Inf Dis J 2004; 23: 931-936.
34. Kabesch M, Tzotcheva I, Carr D et al. A complete screening of the IL4 gene: Novel polymorphisms and their association with asthma and IgE in childhood. J Allergy Clin Immunol 2003; 112: 893-898.
35. Marsh DG, Neely JD, Breazeale DR et al. Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations. Science 1994; 264: 1152-1156.
36. Zhu S, Chan-Yeung M, Becker AB et al. Polymorphisms of the IL-4, TNF-alpha, and Fcepsilon RIbeta genes and the risk of allergic disorders in at-risk infants. Am J Respir Crit Care Med 2000; 161: 1655-1659.
37. Kawashima T, Noguchi E, Arinami T et al. Linkage and association of an interleukin 4 gene polymorphism with atopic dermatitis in Japanese families. J Med Genet 1998; 35: 502-504.
38. Sandford AJ, Chagani T, Zhu S. Polymorphisms in the IL4, IL4RA, and FCERIB genes and asthma severity. J Allergy Clin Immunol. 2000; 106: 135-140.
39. Choi EH, Lee HJ, Yoo T, Chanock SJ. A common haplotype of interleukin-4 gene IL4 is associated with severe respiratory syncytial virus disease in Korean children. J Infect Dis 2002; 186: 1207-1211.
40. Kusakawa S, Heiner DC. Elevated levels of immunoglobulin E in the acute febrile mucocutaneous lymph node syndrome. Pediatr Res 1976; 10: 108-111.
41. Hirao J, Yoshimura N, Homma N, Kano K. Immunological studies on Kawasaki disease: II. Isolation and characterization of an immunosuppressive factor in acute phase sera. Clin Exp Immunol 1987; 67: 433-440.
42. Lin CY, Hwang B. Serial immunologic studies in patients with mucocutaneous lymph node syndrome (Kawasaki disease). Ann Allergy 1987; 59: 291-297.
43. Krous HF, Clausen CR, Ray CG. Elevated immunoglobulin E in infantile polyarteritis nodosa. J Pediatr 1974; 84: 841-845.
44. Landing BH, Larson EJ. Are infantile periarteritis nodosa with coronary artery involvement and fatal mucocutaneous lymph node syndrome the same? Comparison of 20 patients from North America with patients from Hawaii and Japan. Pediatrics 1977; 59: 651-662.
45. Matsubara T, Fujita Y, Sato T, Sasai K, Furukawa S. The prevalence of allergy in Kawasaki disease. Allergy 1998; 53: 815-816.
46. Matsuoka S, Tatara K, Nakagawa R, Mori K, Kuroda Y. Tendency toward atopy in Kawasaki disease. Eur J Pediatr 1997; 156: 30-32.
47. Brosius CL, Newburger JW, Burns JC, Hojnowski-Diaz P, Zierler S, Leung DY. Increased prevalence of atopic dermatitis in Kawasaki disease. Pediatr Infect Dis J 1988; 7: 863-866.
48. Rosenwasser LJ, Klemm DJ, Dresback JK et al. Promoter polymorphisms in the chromosome 5 gene cluster in asthma and atopy. Clin Exp Allergy. 1995; 25 (Suppl 2): 74-78; discussion 95-96.
49. Newburger JW, Takahashi M, Gerber MA et al. Diagnosis, treatment, and long-term management of Kawasaki disease: A statement for health professionals from the Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association. Circulation. 2004; 110: 2747-2771.
50. de Zorzi A, Colan SD, Gauvreau K, Baker AL, Sundel RP, Newburger JW. Coronary artery dimensions may be misclassified as normal in Kawasaki disease. J Pediatr 1998; 133: 254-258.
51. Heath EM, Morken NW, Campbell KA, Tkach D, Boyd EA, Strom DA. Use of buccal cells collected in mouthwash as a source of DNA for clinical testing. Arch Pathol Lab Med 2001; 125: 127-133.
52. Cheng S, Grow MA, Pallaud C et al. A multilocus genotyping assay for candidate markers of cardiovascular disease risk. Genome Res 1999; 9: 936-949.
53. Zee RY, Hoh J, Cheng S et al. Multi-locus interactions predict risk for post-PTCA restenosis: An approach to the genetic analysis of common complex disease. Pharmacogenomics J 2002; 2: 197-201.
54. O'Connell JR, Weeks DE. PedCheck: A program for identification of genotype incompatibilities in linkage analysis. Am J Hum Genet 1998; 63: 259-266.
55. Lange K, Cantor RM, Horvath S et al. Mendel version 4.0: A complete package for the exact genetic analysis of discrete traits in pedigree and population data sets. Am J Hum Genet 2001; 69 (Suppl): A1886.
56. SAGE. Statistical Analysis for Genetic Epidemiology. Computer program package available from Statistical Solutions Ltd, Cork, Ireland, 2002.
57. Abecasis GR, Cookson WO. GOLD - graphical overview of linkage disequilibrium. Bioinformatics 2000; 16: 182-183.
58. Clayton D. TRANSMIT, 2.5.4 edn. Cambridge: MRC Biostatistics Unit, 1999.
59. Cytel. StatXact software for exact nonparametric inference. Cambridge, MA: Cytel Software Corporation, 1997.