Polycitorols A and B, new tricyclic alkaloids from an ascidian

Marine Drugs

Volumn 3, Issue 3, 2005, Pages 78-83

  Issa, Hamad H ^a,b   Tanaka, Junichi ^a   Rachmat, Rachmaniar ^c   Setiawan, Andi ^d   Trianto, Agus ^e   Higa, Tatsuo ^a  

^a UNIVERSITY OF THE RYUKYUS   (Japan)

^b The State Univerisity of Zanzibar   (Tanzania)

^c INDONESIAN INSTITUTE OF SCIENCES   (Indonesia)

^d UNIVERSITY OF LAMPUNG   (Indonesia)

^e DIPONEGORO UNIVERSITY   (Indonesia)

Author keywords

Ascidian; Polycitoridae; Polycitorols; Polycyclic alkaloids; Tricyclic alkaloids

Indexed keywords

ALKALOID; CYLINDRICINE A; CYLINDRICINE B; LEPADIFORMINE; POLYCITOROL A; POLYCITOROL B; UNCLASSIFIED DRUG;

ARTICLE; ASCIDIACEA; CIS ISOMER; DATA ANALYSIS; DRUG ISOLATION; DRUG STRUCTURE; NUCLEAR MAGNETIC RESONANCE; OXYGENATION;

ASCIDIA; ASCIDIACEA; POLYCITORIDAE;

EID: 28044456500     PISSN: 16603397     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md303078     Document Type: Article

References (9)

1. (a) Blackman, A. J.; Li, C.; Hockless, D. C. R.; Skelton, B. W.; White, A. H. Cyclindricines A-B, novel alkaloids from the ascidian Clavelina cylindrica. Tetrahedron 1993, 49, 8645-8656.
2. (b) Li, C.; Blackman, A. J. Cyclindricines C-G, perhydropyrrolo[2,1-j] quinolin-7-one alkaloids from the ascidian Clavelina cylindrica. Aust. J. Chem. 1994, 47, 1355-1361.
3. (c) Li, C.; Blackman, A. Cyclindricines H-K, novel alkaloids from the ascidian Clavelina cylindrica. Aust. J. Chem. 1995, 48, 955-965.
4. Biard, J. F.; Guyot, S.; Roussakis, C.; Verbist, J. F.; Vercauteren, J.; Weber, J. F.; Boukef, K. Lepadiformine, a new marine cytotoxic alkaloid from Clavelina lepadiformis. Tetrahedron Lett. 1994, 35, 2691-2694.
5. Patil, A. D.; Freyer, A. J.; Reichwein, R.; Carte, B.; Killmer, L. B.; Faucette, L.; Johnson, R. K. Fascicularin, a novel tricyclic alkaloid from the ascidian Neptheis fascicularis. Tetrahedron Lett. 1997, 38, 363-364.
6. Abe, H.; Aoyagi, S.; Kibayashi, C. First total synthesis of the marine alkaloid (±)-fascicularin and (±)-lepadiformine based on stereocontrolled intramolecular Acylnitroso-Diels-Alder-Reaction. J. Am. Chem. Soc. 2000, 122, 4583-4592.
7. Sun, P.; Sun, C.; Weinreb, S. M. Stereoselective total syntheses of racemic form and the natural enantiomer of the marine alkaloid lepadiformine via a novel N-acyliminium ion/allylsilane spirocyclization strategy. J. Org. Chem. 2002, 67, 4337-4345.
8. Juge, M.; Grimaud, N.; Biard, J. F.; Sauviat, M. P.; Nabil, M.; Verbist, J. F.; Petit, J. Y. Cardiovascular effects of lepadiformine, an alkaloid isolated from the ascidians Clavelina lepadiformis (Muller) and C. moluccensis (Sluiter). Toxicon 2001, 39, 1231-1237.
9. Issa, H. H.; Tanaka, J.; Rachmat, R.; Higa, T. Floresolides, new metacyclophane hydroquinone lactones from an ascidian, Aplidium sp. Tetrahedron Lett. 2003, 44, 1243-1245.