Floresolides, new metacyclophane hydroquinone lactones from an ascidian, Aplidium sp.

Tetrahedron Letters

Volumn 44, Issue 6, 2003, Pages 1243-1245

  Issa, Hamad H ^a   Tanaka, Junichi ^a   Rachmat, Rachmaniar ^b   Higa, Tatsuo ^a  

^a UNIVERSITY OF THE RYUKYUS   (Japan)

^b INDONESIAN INSTITUTE OF SCIENCES   (Indonesia)

Author keywords

Cyclofarnesylated hydroquinone; Cytotoxin; Marine natural product; Metacyclophane; X ray diffraction

Indexed keywords

FLORESOLIDE; HYDROQUINONE DERIVATIVE; LACTONE DERIVATIVE; METACYCLOPHANE DERIVATIVE; UNCLASSIFIED DRUG;

APLIDIUM LONGITHORAX; ARTICLE; ASCIDIACEA; CHEMICAL STRUCTURE; CONTROLLED STUDY; NONHUMAN; SPECTROSCOPY; STRUCTURE ANALYSIS; X RAY DIFFRACTION;

APLIDIUM; ASCIDIA; LONGITHORAX;

EID: 0037415456     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(02)02812-5     Document Type: Article

References (7)

1. Fu X., Hossain M.B., van der Helm D., Schmitz F.J. J. Am. Chem. Soc. 116:1994;12125-12126.
2. Fu X., Hossain M.B., Schmitz F.J., van der Helm D. J. Org. Chem. 62:1997;3810-3819.
3. Fu X., Ferreira L.G., Schmitz F.J. J. Nat. Prod. 62:1999;1306-1310.
4. Davis R.A., Carroll A.R., Quinn R.J. J. Nat. Prod. 62:1999;158-160.
5. Davis R.A., Carroll A.R., Quinn R.J. J. Nat. Prod. 62:1999;1405-1409.
6. The ascidian has tentatively been identified as Aplidium sp. by Dr. F. Monniot, Museum national d'histoire Naturalle, Paris. A voucher specimen (No. 01F67) is deposited in our laboratory at University of the Ryukyus.
7. w=0.023 for 2248 observed reflections [I>3.00σ(I)] and 257 variable parameters. Flack parameter was calculated to be 0.0515 (0.00030). Crystallographic data (excluding structure factors) for the structure in this paper have been deposited with the Cambridge Crystallographic Data Centre as supplementary publication number CCDC 193560. Copies of the data can be obtained, free of charge, on application to CCDC, 12 Union Road, Cambridge, CB2 1EZ, UK [fax: +44(0)-1223-336033 or e-mail: deposit@ccdc.cam.ac.uk].