The future of G protein-coupled receptors as targets in drug discovery

IDrugs

Volumn 8, Issue 11, 2005, Pages 909-913

  Lundstrom, Kenneth ^a  

^a BioXtal   (Switzerland)

Author keywords

Drug discovery; Functional studies; G protein coupled receptor; Structure based drug design

Indexed keywords

1,1' [1,4 PHENYLENEBIS(METHYLENE)]BIS(1,4,8,11 TETRAAZACYCLOTETRADECANE); CANDESARTAN; CETIRIZINE; CHEMOKINE RECEPTOR ANTAGONIST; CLOPIDOGREL; DESLORATADINE; FENTANYL; FEXOFENADINE; G PROTEIN COUPLED RECEPTOR; GOSERELIN; IRBESARTAN; LEUPRORELIN; LIGAND; LOSARTAN; METOPROLOL; MONTELUKAST; OCTREOTIDE; OLANZAPINE; QUETIAPINE; RISPERIDONE; SALMETEROL; SUMATRIPTAN; TAMSULOSIN; VALSARTAN;

ACROMEGALY; ANTIVIRAL ACTIVITY; ARTICLE; ASTHMA; CLINICAL TRIAL; CRYSTALLOGRAPHY; DIMERIZATION; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG INDICATION; DRUG SCREENING; DRUG STRUCTURE; DRUG TARGETING; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYPERTENSION; MIGRAINE; NONHUMAN; PAIN; PROSTATE CANCER; PROSTATE HYPERTROPHY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; RHINITIS; SCHIZOPHRENIA; SIGNAL TRANSDUCTION; THROMBOSIS;

ANIMALS; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HUMANS; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 28044444551     PISSN: 13697056     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

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5. Lundstrom K: Structural genomics of GPCRs. Trends Biotechnol (2005) 23(2):103-108.
6. Lundstrom K (Ed): Structural Genomics on Membrane Proteins. CRC Press, Boca Raton, FL, USA (2006): in press.
7. Lundstrom K, Chiu M (Eds): G Protein-Coupled Receptors in Drug Discovery. CRC Press, Boca Raton, FL, USA (2005).
8. Sarramegna V, Talmont F, Demange P, Millon A: Heterologous expression of G protein-coupled receptors: Comparison of expression systems from the standpoint of large-scale production and purification. Cell Mol Life Sci (2003) 60(8):1529-1546.