Safety of zinc gluconate glycine (Cold-Eeze) in a geriatric population: A randomized, placebo-controlled, double-blind trial

American Journal of Therapeutics

Volumn 12, Issue 6, 2005, Pages 612-617

  Silk, Raymond ^a   LeFante, Carolyn ^b  

^a Silk Clinic   (United States)

^b Synergy Research Inc   (United States)

Author keywords

Cold; Cold Eeze; Geriatric; Prophylaxis; Safety; Zinc gluconate glycine lozenges

Indexed keywords

GLYCINE DERIVATIVE; PLACEBO; UNCLASSIFIED DRUG; ZINC GLUCONATE GLYCINE;

ADULT; AGED; ARTHRITIS; BURNING SENSATION; CANCER; CLINICAL TRIAL; COMMON COLD; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEPRESSION; DISEASE SEVERITY; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG SAFETY; DRUG SELF ADMINISTRATION; DRUG TOLERABILITY; FEMALE; HEART DISEASE; HUMAN; HYPERGLYCEMIA; HYPERTENSION; LABORATORY TEST; LOZENGE; LUNG DISEASE; MAJOR CLINICAL STUDY; MALE; NAUSEA; OSTEOPOROSIS; PHYSICAL EXAMINATION; POPULATION; PRIORITY JOURNAL; PROSTATE DISEASE; RANDOMIZED CONTROLLED TRIAL; SENESCENCE; STOMACH DISEASE; STROKE; TABLET; XEROSTOMIA;

AGED; AGED, 80 AND OVER; COMMON COLD; DOUBLE-BLIND METHOD; FEMALE; GERIATRICS; GLUCONATES; GLYCINE; HUMANS; MALE; MIDDLE AGED; ZINC;

EID: 28044440873     PISSN: 10752765     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mjt.0000179115.04316.18     Document Type: Conference Paper

References (24)

1. National Institute of Allergy and Infectious Diseases Fact Sheet. The common cold. 2001. Available at: http://www.niaid.nih.gov/factsheets/cold.htm.
2. Mäkelä MJ, Puhakka T, Ruuskanen O, et al. Viruses and bacteria in the etiology of the common cold. J Clin Microbiol. 1998;36:539-542.
3. Jefferson TO, Tyrrell D. Antivirals for the common cold. Cochrane Database Syst Rev. 2002;3:CD002743.
4. Arroll B, Kenealy T. Antibiotics for the common cold. Cochrane Database Syst Rev. 2000;3:CD000247.
5. Johnson G, Helman C. Remedy or cure? Lay beliefs about over-the-counter medicines for coughs and colds. Br J Gen Pract. 2004;54:98-102.
6. Melchart D, Linde K, Fischer P, et al. Echinacea for preventing and treating the common cold. Cochrane Database Syst Rev. 2000;2:CD000530.
7. Takkouche B, Regueira-Mendez C, Garcia-Closas R, et al. Intake of vitamin C and zinc and risk of common cold: a cohort study. Epidemiology. 2002;13:38-44.
8. Turner RB, Cetnarowski WE. Effect of treatment with zinc gluconate or zinc acetate on experimental and natural colds. Clin Infect Dis. 2000;31:1202-1208.
9. Al-Nakib W, Higgins PG, Barrow I, et al. Prophylaxis and treatment of rhinovirus colds with zinc gluconate lozenges. J Antimicrob Chemother. 1987;20:893-901.
10. Prasad AS, Fitzgerald JT, Bao B, et al. Duration of symptoms and plasma cytokine levels in patients with the common cold treated with zinc acetate. A randomized, double-blind, placebo-controlled trial. Ann Intern Med. 2000;133:245-252.
11. McElroy BH, Miller SP. Effectiveness of zinc gluconate glycine lozenges (Cold-Eeze) against the common cold in school-aged subjects: a retrospective chart review. Am J Ther. 2002;9:472-475.
12. Godfrey JC, Conant Sloane B, Smith DS, et al. Zinc gluconate and the common cold: a controlled clinical study. J Int Med Res. 1992;20:234-246.
13. McElroy BH, Miller SP. An open-label, single-center, phase IV clinical study of the effectiveness of zinc gluconate glycine lozenges (Cold-Eeze) in reducing the duration and symptoms of the common cold in school-aged subjects. Am J Ther. 2003;10:324-329.
14. Novick SG, Godfrey JC, Godfrey NJ, et al. How does zinc modify the common cold? Clinical observations and implications regarding mechanisms of action. Med Hypotheses. 1996;46:295-302.
15. Amoako EP, Richardson-Campbell L, Kennedy-Malone L. Self-medication with over-the-counter drugs among elderly adults. J Gerontol Nurs. 2003;29:10-15.
16. Reeves DS, Finch RG, Bax RP, et al. Self-medication of antibacterials without prescription (also called 'over-the-counter' use). A report of a Working Party of the British Society for Antimicrobial Chemotherapy. J Antimicrob Chemother. 1999;44:163-177.
17. Macknin ML, Piedmonte M, Calendine C, et al. Zinc gluconate lozenges for treating the common cold in children: a randomized controlled trial. JAMA. 1998;279:1962-1967.
18. Schwartz SL, Fischer JS, Kipnes MS. Sugar-free zinc gluconate glycine lozenges (Cold-Eeze) do not adversely affect glucose control in patients with type 1 or type 2 diabetes mellitus. Am J Ther. 2001;8:247-252.
19. Mossad SB, Macknin ML, Medendorp SV, et al. Zinc gluconate lozenges for treating the common cold. A randomized, double-blind, placebo-controlled study. Ann Intern Med. 1996;125:81-88.
20. Tapiero H, Tew KD. Trace elements in human physiology and pathology: zinc and metallothioneins. Biomed Pharmacother. 2003;57:399-411.
21. Hambidge KM, Krebs NF, Miller L. Evaluation of zinc metabolism with use of stable-isotope techniques: implications for the assessment of zinc status. Am J Clin Nutr. 1998;68(suppl):410S-413S.
22. National Institutes of Health. Facts about dietary supplements. Zinc. 2002. Available at: http://www.cc.nih.gov/ccc/supplements/zinc.html.
23. Maher TJ. Zinc. Continuing education module. 1999. Available at: http://www.nhir.com/tests/zinc.pdf.
24. Wholehealthmd.com. Supplements. Zinc-drug interactions. 2000. Available at: http://www.wholehealthmd.com/refshelf/substances_interact/0,1661,10071,00. html.