Time course of changes in sperm morphometry and semen variables during testosterone-induced suppression of human spermatogenesis

Human Reproduction

Volumn 20, Issue 11, 2005, Pages 3091-3100

  Garrett, C ^a   Liu, D Y ^a   McLachlan, R I ^b   Baker, H W G ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b MONASH MEDICAL CENTRE   (Australia)

Author keywords

Automated image analysis; Male contraception; Sperm morphometry; Spermatogenic suppression

Indexed keywords

MALE CONTRACEPTIVE AGENT; TESTOSTERONE;

ADULT; ARTICLE; AZOOSPERMIA; CELL STRUCTURE; CELL VIABILITY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; EPIDIDYMIS; HALF LIFE TIME; HORMONAL CONTRACEPTION; HUMAN; HUMAN CELL; MALE; MALE GENITAL SYSTEM; MULTICENTER STUDY; OLIGOSPERMIA; QUANTITATIVE ANALYSIS; SEMEN ANALYSIS; SEMINIFEROUS TUBULE; SPERMATOGENESIS; SPERMATOZOON COUNT; SPERMATOZOON DENSITY; SPERMATOZOON MOTILITY; TIME;

EID: 27944504321     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/dei174     Document Type: Article

References (31)

1. Amann RP and Howards SS (1980) Daily spermatozoal production and epididymal spermatozoal reserves of the human male. J Urol 124,211-215.
2. Anderson RA and Wu FC (1996) Comparison between testosterone enanthate-induced azoospermia and oligozoospermia in a male contraceptive study. II. Pharmacokinetics and pharmacodynamics of once weekly administration of testosterone enanthate. J Clin Endocrinol Metab 81,896-901.
3. Bedford JM (1994) The status and the state of the human epididymis. Hum Reprod 9,2187-2199.
4. Bedford JM, Bent MJ and Calvin H (1973) Variations in the structural character and stability of the nuclear chromatin in morphologically normal human spermatozoa. J Reprod Fertil 33,19-29.
5. Burger HG and Baker HWG (1984) Therapeutic considerations and results of gonadotropin treatment in male hypogonadotropic hypogonadism. Ann N Y Acad Sci 438,447-453.
6. Clermont Y (1963) The cycle of the seminiferous epithelium in man. Am J Anat 112,35-51.
7. Freund M and Davis JE (1969) Disappearance rate of spermatozoa from the ejaculate following vasectomy. Fertil Steril 20,163-170.
8. Garrett C and Baker HWG (1995) A new fully automated system for the morphometric analysis of human sperm heads. Fertil Steril 63,1306-1317.
9. Garrett C, Liu DY and Baker HWG (1997) Selectivity of the human spermzona pellucida binding process to sperm head morphometry. Fertil Steril 67,362-371.
10. Garrett C, Liu DY, Clarke GN, Rushford DD and Baker HWG (2003) Automated semen analysis: 'zona pellucida preferred' sperm morphometry and straight-line velocity are related to pregnancy rate in subfertile couples. Hum Reprod 18,1643-1649.
11. Handelsman DJ, Conway AJ and Boylan LM (1992) Suppression of human spermatogenesis by testosterone implants. J Clin Endocrinol Metab 75,1326-1332.
12. Handelsman DJ, Conway AJ, Howe CJ, Turner L and Mackey MA (1996) Establishing the minimum effective dose and additive effects of depot progestin in suppression of human spermatogenesis by a testosterone depot. J Clin Endocrinol Metab 81,4113-4121.
13. Jeulin C, Feneux D, Serres C, Jouannet P, Guillet-Rosso F, Belaisch-Allart J, Frydman R and Testart J (1986) Sperm factors related to failure of human in-vitro fertilization. J Reprod Fertil 76,735-744.
14. Johnson L and Varner DD (1988) Effect of daily spermatozoan production but not age on transit time of spermatozoa through the human epididymis. Biol Reprod 39,812-817.
15. Liu DY and Baker HWG (1994) Acrosome status and morphology of human spermatozoa bound to the zona pellucida and oolemma determined using oocytes that failed to fertilize in vitro. Hum Reprod 9,673-679.
16. Liu DY, Johnston R and Baker HWG (1995) Ability of spermatozoa to bind to the zona pellucida during oligozoospermia induced with testosterone during a male contraceptive trial. Int J Androl 18 (Suppl 1),39-44.
17. McLachlan RI, McDonald J, Rushford D, Robertson DM, Garrett C and Baker HWG (2000) Efficacy and acceptability of testosterone implants, alone or in combination with a 5alpha-reductase inhibitor, for male hormonal contraception. Contraception 62,73-78.
18. McLachlan RI, O'Donnell L, Stanton PG, Balourdos G, Frydenberg M, de Kretser DM and Robertson DM (2002) Effects of testosterone plus medroxyprogesterone acetate on semen quality, reproductive hormones, and germ cell populations in normal young men. J Clin Endocrinol Metab 87,546-556.
19. Meriggiola MC, Bremner WJ, Paulsen CA, Valdiserri A, Incorvaia L, Motta R, Pavani A, Capelli M and Flamigni C (1996) A combined regimen of cyproterone acetate and testosterone enanthate as a potentially highly effective male contraceptive. J Clin Endocrinol Metab 81,3018-3023.
20. O'Donnell L, McLachlan RI, Wreford NG and Robertson DM (1994) Testosterone promotes the conversion of round spermatids between stages VII and VIII of the rat spermatogenic cycle. Endocrinology 135,2608-2614.
21. O'Donnell L, McLachlan RI, Wreford NG, de Kretser DM and Robertson DM (1996) Testosterone withdrawal promotes stage-specific detachment of round spermatids from the rat seminiferous epithelium. Biol Reprod 55,895-901.
22. Rowley MJ, Teshima F and Heller CG (1970) Duration of transit of spermatozoa through the human male ductular system. Fertil Steril 21,390-396.
23. Turner L, Conway AJ, Jimenez M, Liu PY, Forbes E, McLachlan RI and Handelsman DJ (2003) Contraceptive efficacy of a depot progestin and androgen combination in men. J Clin Endocrinol Metab 88,4659-4667.
24. Wang C, Leung A, Superlano L, Steiner B and Swerdloff RS (1997) Oligozoospermia induced by exogenous testosterone is associated with normal functioning residual spermatozoa. Fertil Steril 68,149-153.
25. Wang C, Berman NG, Veldhuis JD, Der T, McDonald V, Steiner B and Swerdloff RS (1998) Graded testosterone infusions distinguish gonadotropin negative-feedback responsiveness in Asian and white men - a Clinical Research Center study. J Clin Endocrinol Metab 83,870-876.
26. WHO (1990) Contraceptive efficacy of testosterone-induced azoospermia in normal men. World Health Organization Task Force on methods for the regulation of male fertility. Lancet 336,955-959.
27. WHO (1992) Laboratory Manual for the Examination of Human Semen and Sperm-Cervical Mucus Interaction. 3rd edn, Cambridge University Press, Cambridge, UK.
28. WHO (1996) Contraceptive efficacy of testosterone-induced azoospermia and oligozoospermia in normal men. Fertil Steril 65,821-829.
29. Wu FC and Aitken RJ (1989) Suppression of sperm function by depot medroxyprogesterone acetate and testosterone enanthate in steroid male contraception. Fertil Steril 51,691-698.
30. Zhengwei Y, Wreford NG, Bremner WJ, Matsumoto AM, Anawalt BA and McLachlan RI (1998a) Immature spermatids are not prevalent in semen from men who are receiving androgen-based contraceptive regimens. Fertil Steril 69,89-95.
31. Zhengwei Y, Wreford NG, Royce P, de Kretser DM and McLachlan RI (1998b) Stereological evaluation of human spermatogenesis after suppression by testosterone treatment: Heterogeneous pattern of spermatogenic impairment. J Clin Endocrinol Metab 83,1284-1291.