The basis of gender assignment in disorders of somatosexual differentiation

Hormone Research

Volumn 64, Issue SUPPL. 2, 2005, Pages 18-22

  Hiort, Olaf ^a,b   Thyen, Ute ^a   Holterhus, Paul Martin ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

^b UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

Androgen biosynthesis; Androgen insensitivity; Gender; Intersex disorders; Sexual determination; Sexual differentiation

Indexed keywords

ANDROGEN; ESTROGEN;

ANDROGEN RELEASE; BRAIN MATURATION; CONFERENCE PAPER; DIAGNOSTIC ACCURACY; ESTROGEN RELEASE; EVIDENCE BASED MEDICINE; GENDER IDENTITY; GENDER IDENTITY DISORDER; HERMAPHRODITISM; HUMAN; MOLECULAR MECHANICS; PRIORITY JOURNAL; REPRODUCTIVE HEALTH; SEX DIFFERENCE;

GENDER IDENTITY; GENITALIA; GONADS; HUMANS; INFANT, NEWBORN; SEX DETERMINATION (ANALYSIS); SEX DIFFERENTIATION DISORDERS;

EID: 27944495739     PISSN: 03010163     EISSN: None     Source Type: Journal    
DOI: 10.1159/000087748     Document Type: Conference Paper

References (14)

1. Thyen U, Richter-Appelt H, Wiesemann C, Holterhus PM, Hiort O: Deciding on gender in children with intersex-conditions: considerations and controversies. Treat Endocrinol 2005;4:1-8.
2. Hines M, Collear MS: Gonadal hormones and sexual differentiation of human behavior: Developments from research on endocrine syndromes and studies of brain structure. Annu Rev Sex Res 1993;4:1-48.
3. Brennan J, Capel B: One tissue, two fates: Molecular genetic events that underlie testis versus ovary development. Nat Rev Genet 2004;5:509-521.
4. Hiort O, Holterhus PM: The molecular basis of male sexual differentiation. Eur J Endocrinol 2000;142:101-110.
5. Canto P, Soderlund D, Reyes E, Mendez JP: Mutations in the Desert hedgehog (DHH) gene in patients with 46,XY complete pure gonadal dysgenesis. J Clin Endocrinol Metab 2004;89:4480-4483.
6. Haraguchi R, Mo R, Hui C, Motoyama J, Makino S, Shiroishi T, Gaffield W, Yamada G: Unique functions of Sonic hedgehog signaling during external genitalia development. Development 2001;128:4241-4250.
7. Haraguchi R, Suzuki K, Murakami R, Sakai M, Kamikawa M, Kengaku M, Sekine K, Kawano H, Kato S, Ueno N, Yamada G: Molecular analysis of external genitalia formation: The role of fibroblast growth factor (Fgf) genes during genital tubercle formation. Development 2000;127:2471-2479.
8. Mortlock DP, Innis JW: Mutation of HOXA13 in hand-foot-genital syndrome. Nat Genet 1997;15:179-180.
9. Fluck CE, Tajima T, Pandey AV, Arlt W, Okuhara K, Verge CF, Jabs EW, Mendonca BB, Fujieda K, Miller WL: Mutant P450 oxidoreductase causes disordered steroidogenesis with and without Antley-Bixler syndrome. Nat Genet 2004;36:228-230.
10. Twesten W, Holterhus PM, Sippell WG, Morlot M, Schumacher H, Schenk B, Hiort O: Clinical, endocrine, and molecular genetic findings in patients with 17β-hydroxy-steroid dehydrogenase deficiency. Horm Res 2000;53:26-31.
11. Hiort O, Reinecke S, Thyen U, Jürgensen M, Holterhus PM, Schön D, Richter-Appelt H: Aspects of puberty in disorders of somatosexual differentiation. J Pediatr Endocrinol Metab 2003;16:297-306.
12. Hiort O: Androgens and puberty. Best Pract Res Clin Endocrinol Metab 2002;16:31-41.
13. Money J, Hampson JG: Hermaphroditism: recommendations concerning assignment of sex, change of sex, and psychologic management. Bull Johns Hopkins Hosp 1955;97:284-300.
14. Diamond M, Sigmundson H: Management of intersexuality. Guidelines for dealing with persons with ambiguous genitalia. Arch Pediatr Adolesc Med 1997;151:1046-1050.