Cancer immunotherapy based on intracellular hyperthermia using magnetite nanoparticles: A novel concept of "heat-controlled necrosis" with heat shock protein expression

Cancer Immunology, Immunotherapy

Volumn 55, Issue 3, 2006, Pages 320-328

  Ito, Akira ^a   Honda, Hiroyuki ^a   Kobayashi, Takeshi ^a,b  

^a NAGOYA UNIVERSITY   (Japan)

^b CHUBU UNIVERSITY   (Japan)

Author keywords

Glioma; Heat shock proteins; Hyperthermia; Magnetite; Melanoma; Tumor immunity

Indexed keywords

GLUCOSE REGULATED PROTEIN; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 70; MAGNETITE; NANOPARTICLE;

APOPTOSIS; CANCER IMMUNOTHERAPY; CELL DEATH; CONFERENCE PAPER; HEAT; HEAT STRESS; HYPERTHERMIA; IMMUNITY; IMMUNOGENICITY; NECROSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SYNTHESIS; TEMPERATURE MEASUREMENT; TUMOR IMMUNITY;

ANIMALS; FERROSOFERRIC OXIDE; HEAT-SHOCK PROTEINS; HUMANS; HYPERTHERMIA, INDUCED; IMMUNOTHERAPY; NANOSTRUCTURES; NECROSIS; NEOPLASMS;

EID: 27944486495     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00262-005-0049-y     Document Type: Conference Paper

References (55)

1. Asea A, Kraeft SK, Kurt-Jones EA, Stevenson MA, Chen LB, Finberg RW, Koo GC, Calderwood SK (2000) HSP70 stimulates cytokine production through a CD14-dependent pathway, demonstrating its dual role as a chaperon and cytokine. Nat Med 6:435-442
2. Basu S, Binder R, Suto R, Anderson KM, Srivastava PK (2000) Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NFkB pathway. Int Immunol 12:1539-1546
3. Becker T, Hartl FU, Wieland F (2002) CD40, an extracellular receptor for binding and uptake of Hsp70-peptide complexes. J Cell Biol 158:1277-1285
4. Belli F, Testori A, Rivoltini L, Maio M, Andreola G, Sertoli MR, Gallino G, Piris A, Cattelan A, Lazzari I, Carrabba M, Scita G, Santantonio C, Pilla L, Tragni G, Lombardo C, Arienti F, Marchiano A, Queirolo P, Bertolini F, Cova A, Lamaj E, Ascani L, Camerini R, Corsi M, Cascinelli N, Lewis JJ, Srivastava P, Parmiani G (2002) Vaccination of metastatic melanoma patients with autologous tumor-derived heat shock protein gp96-peptide complexes: clinical and immunologic findings. J Clin Oncol 20:4169-4180
5. Castelli C, Rivoltini L, Rini F, Belli F, Testori A, Maio M, Mazzaferro V, Coppa J, Srivastava PK, Parmiani G (2004) Heat shock proteins: biological functions and clinical application as personalized vaccines for human cancer. Cancer Immunol Immunother 53:227-233
6. Chandawarkar RY, Wagh MS, Kovalchin JT, Srivastava P (2004) Immune modulation with high-dose heat-shock protein gp96: therapy of murine autoimmune diabetes and encephalomyelitis. Int Immunol 16:615-624
7. Dewey WC, Hopwood LE, Sapareto LA, Gerweck LE (1977) Cellular responses to combinations of hyperthermia and radiation. Radiology 123:463-474
8. Dressel R, Lubbers M, Walter L, Herr W, Gunther E (1999) Enhanced susceptibility to cytotoxic T lymphocytes without increase of MHC class I antigen expression after conditional overexpression of heat shock protein 70 in target cells. Eur J Immunol 29:3925-3935
9. Garnett CT, Palena C, Chakarborty M, Tsang KY, Schlom J, Hodge JW (2004) Sublethal irradiation of human tumor cells modulates phenotype resulting in enhanced killing by cytotoxic T lymphocytes. Cancer Res 64:7985-7994
10. Gordon RT, Hines JR, Gordon D (1979) Intracellular hyperthermia. A biophysical approach to cancer treatment via intracellular temperature and biophysical alterations. Med Hypothesis 5:83-102
11. Hauser H, Shen L, Gu QL, Krueger S, Chen SY (2004) Secretory heat-shock protein as a dendritic cell-targeting molecule: a new strategy to enhance the potency of genetic vaccines. Gene Ther 11:924-932
12. Ito A, Tanaka K, Honda H, Abe S, Yamaguchi H, Kobayashi T (2003) Complete regression of mouse mammary carcinoma with a size greater than 15 mm by frequent repeated hyperthermia using magnetite nanoparticles. J Biosci Bioeng 96:364-369
13. Ito A, Shinkai M, Honda H, Wakabayashi T, Yoshida J, Kobayashi T (2001) Augmentation of MHC class I antigen presentation via heat shock protein expression by hyperthermia. Cancer Immunol Immunother 50:515-522
14. Ito A, Shinkai M, Honda H, Yoshikawa K, Saga S, Wakabayashi T, Yoshida J, Kobayashi T (2003) Heat shock protein 70 expression induces antitumor immunity during intracellular hyperthermia using magnetite nanoparticles. Cancer Immunol Immunother 52:80-88
15. Ito A, Kuga Y, Honda H, Kikkawa H, Horiuchi A, Watanabe Y, Kobayashi T (2004) Magnetite nanoparticle-loaded anti-HER2 immunoliposomes for combination of antibody therapy with hyperthermia. Cancer Lett 212:167-175
16. Ito A, Tanaka K, Kondo K, Shinkai M, Honda H, Matsumoto K, Saida T, Kobayashi T (2003) Tumor regression by combined immunotherapy and hyperthermia using magnetic nanoparticles in an experimental subcutaneous murine melanoma. Cancer Sci 94:308-313
17. Ito A, Shinkai M, Honda H, Kobayashi T (2001) Heat-inducible TNF-alpha gene therapy combined with hyperthermia using magnetic nanoparticles as a novel tumor-targeted therapy. Cancer Gene Ther 8:649-654
18. Ito A, Matsuoka M, Honda H, Kobayashi T (2004) Aniti-tumor effects of combined therapy of recombinant heat shock protein 70 and hyperthermia using magnetic nanoparticles in an experimental subcutaneous murine melanoma. Cancer Immunol Immunother 53:26-32
19. Ito A, Matsuoka M, Honda H, Kobayashi T (2003) Heat shock protein 70 gene therapy combined with hyperthermia using magnetic nanoparticles. Cancer Gene Ther 10:918-925
20. Jordan A, Wust P, Fähling H, John W, Hinz A, Felix R (1993) Inductive heating of ferrimagnetic particles and magnetic fluids: physical evaluation of their potential for hyperthermia. Int J Hyperthermia 9:51-68
21. Jordan A, Wust P, Scholz R, Tesch B, Fähling H, Mitrovics T, Vogl T, Cervós-Navarro J, Felix R (1996) Cellular uptake of magnetic fluid particles and their effects on human adenocarcinoma cells exposed to AC magnetic fields in vitro. Int J Hyperthermia 12:705-722
22. Kato N, Kobayashi T, Honda H (2003) Screening of stress enhancer based on analysis of gene expression profiles: enhancement of hyperthermia-induced tumor necrosis by an MMP-3 inhibitor. Cancer Sci 94:644-649
23. Labarriere N, Bretaudeau L, Gervois N, Bodinier M, Bougras G, Diez E, Lang F, Gregoire M, Jotereau F (2002) Apoptotic body-loaded dendritic cells efficiently cross-prime cytotoxic T lymphocytes specific for NA17-A antigen but not for Melan-A/MART-1 antigen. Int J Cancer 101:280-286
24. Le B, Shinkai M, Kitade T, Honda H, Yoshida J, Wakabayashi T, Kobayashi T (2001) Preparation of tumor-specific magnetoliposomes and their application for hyperthermia. J Chem Eng Jpn 34:66-72
25. Lindquist S (1986) The heat-shock response. Annu Rev Biochem 55:1151-1191
26. Massa C, Guiducci C, Arioli I, Parenza M, Colombo MP, Melani C (2004) Enhanced efficacy of tumor cell vaccines transfected with secretable hsp70. Cancer Res 64:1502-1508
27. Matsuoka F, Shinkai M, Honda H, Kubo T, Sugita T, Kobayashi T (2004) Hyperthermia using magnetite cationic liposomes for hamster osteosarcoma. Biomagn Res Technol 2:3
28. Matsuno H, Tohnai I, Mitsudo K, Hayashi Y, Ito M, Shinkai M, Kobayashi T, Yoshida J, Ueda M (2001) Interstitial hyperthermia using magnetite cationic liposomes inhibit to tumor growth of VX-7 transplanted tumor in rabbit tongue. Jpn J Hyperthermic Oncol 17:141-149
29. Mazzaferro V, Coppa J, Carrabba MG, Rivoltini L, Schiavo M, Regalia E, Mariani L, Camerini T, Marchiano A, Andreola S, Camerini R, Corsi M, Lewis JJ, Srivastava PK, Parmiani G (2003) Vaccination with autologous tumor-derived heat-shock protein gp96 after liver resection for metastatic colorectal cancer. Clin Cancer Res 9:3235-3245
30. Ménoret A, Chandawarkar R (1998) Heat-shock protein-based anticancer immunotherapy: an idea whose time has come. Sem Immunol 25:654-660
31. Milani V, Noessner E, Ghose S, Kuppner M, Ahrens B, Scharner A, Gastpar R, Issels RD (2002) Heat shock protein 70: role in antigen presentation and immune stimulation. Int J Hyperthermia 18:563-575
32. Moroz P, Jones SK, Gray BN (2002) Magnetically mediated hyperthermia: current status and future directions. Int J Hyperthermia 18:267-284
33. Mosser DD, Caron AW, Bourget L, Meriin AB, Sherman MY, Morimoto RI, Massie B (2000) The chaperon function of hsp 70 is required for protection against stress-induced apoptosis. Mol Cell Biol 20:7146-7159
34. Shinkai M, Yanase M, Honda H, Wakabayashi T, Yoshida J, Kobayashi T (1996) Intracellular hyperthermia for cancer using magnetite cationic liposome: in vitro study. Jpn J Cancer Res 87:1179-1183
35. Shinkai M, Le B, Honda H, Yoshikawa K, Shimizu K, Saga S, Wakabayashi T, Yoshida J, Kobayashi T (2001) Targeting hyperthermia for renal cell carcinoma using human MN antigen-specific magnetoliposomes. Jpn J Cancer Res 92:1138-1145
36. Srivastava PK, Ménoret A, Basu S, Binder R, Quade K (1998) Heat shock proteins come of age: primitive functions acquired new roles in an adaptive world. Immunity 8:657-665
37. Srivastava PK, Maki RG (1991) Stress-induced proteins in immune response to cancer. Curr Top Microbiol Immunol 167:109-123
38. Srivastava PK, Heike M (1993) Tumor-specific immunogenicity of stress-induced proteins: convergence of two evolutionary pathways of antigen presentation? Semin Immunol 3:57-64
39. Srivastava PK, Udono H, Blachere NE, Li Z (1994) Heat shock proteins transfer peptides during antigen processing and CTL priming. Immunogenetics 39:93-98
40. Srivastava PK (2002) Roles of heat-shock proteins in innate and adaptive immunity. Nat Rev Immunol 2:185-194
41. Srivastava PK (2002) Interaction of heat shock proteins with peptides and antigen presenting cells: chaperoning of the innate and adaptive immune responses. Annu Rev Immunol 20:395-425
42. Subjeck JR, Sciandra JJ, Chao CF, Johnson RJ (1982) Heat shock proteins and biological response to hyperthermia. Br J Cancer 45:127-131
43. Subjeck JR, Sciandra JJ, Johnson RJ (1982) Heat shock proteins and thermotolerance; a comparison of induction kinetics. Br J Radiol 55:579-584
44. Suzuki M, Shinkai M, Honda H, Kobayashi T (2003) Anti-cancer effect and immune induction by hyperthermia of malignant melanoma using magnetite cationic liposomes. Melanoma Res 13:129-135
45. Tanaka A, Ito A, Kobayashi T, Kawamura T, Shimada S, Matsumoto K, Saida T, Honda H (2005) Intratumoral injection of immature dendritic cells enhances antitumor effect of hyperthermia using magnetic nanoparticles. Int J Cancer 116:624-633
46. Tanaka A, Ito A, Kobayashi T, Kawamura T, Shimada S, Matsumoto K, Saida T, Honda H (2005) Heat immunotherapy using magnetic nanoparticles and dendritic cells for T-lymphoma. J Bio Bioeng 100:112-115
47. Todryk S, Melcher AA, Hardwick N, Linardakis E, Bateman A, Colombo MP, Stoppacciaro A, Vile RG (1999) Heat shock protein 70 induced during tumor cell killing induces Th1 cytokines and targets immature dendritic cell precursors to enhance antigen uptake. J Immunol 163:1398-1408
48. Udono H, Srivastava PK (1994) Comparison of tumor-specific immunogenicities of stress-induced protein gp96, hsp90, and hsp70. J Immunol 152:5398-5403
49. Van der Zee J (2002) Heating the patient: a promising approach? Annu Oncol 13:1173-1184
50. Wells AD, Rai SK, Salvato MS, Band H, Malkovsky M (1998) Hsp72-mediated augmentation of MHC class I surface expression and endogenous antigen presentation. Int Immunol 10:609-617
51. Wells AD, Malkovsky M (2000) Heat shock proteins, tumor immunogenicity and antigen presentation: an integrated view. Immunol Today 21:129-132
52. Yanase M, Shinkai M, Honda H, Wakabayashi T, Yoshida J, Kobayashi T (1998) Intracellular hyperthermia for cancer using magnetite cationic liposome: an in vivo study. Jpn J Cancer Res 89:463-469
53. Yanase M, Shinkai M, Honda H, Wakabayashi T, Yoshida J, Kobayashi T (1998) Antitumor immunity induction by intracellular hyperthermia using magnetite cationic liposomes. Jpn J Cancer Res 89:775-782
54. Ye J, Chen GS, Song HP, Li ZS, Huang YY, Qu P, Sun YJ, Zhang XM, Sui YF (2004) Heat shock protein 70/MAGE-1 tumor vaccine can enhance the potency of MAGE-1-specific cellular immune responses in vivo. Cancer Immunol Immunother 53:825-834
55. Yonezawa M, Ohtsuka T, Matsui N, Tsuji H, Kato KH, Moriyama A, Kato T (1996) Hyperthermia induces apoptosis in malignant fibrous histiocytoma cells in vitro. Int J Cancer 66:347-351