A column-based 'flush and flow' system for the asymmetric α-chlorination of acid halides

Tetrahedron Asymmetry

Volumn 16, Issue 21, 2005, Pages 3481-3483

  Bernstein, Daniel ^a   France, Stefan ^a   Wolfer, Jamison ^a   Lectka, Thomas ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACID HALIDE; ALKALOID DERIVATIVE; CHLORINE DERIVATIVE; ESTER DERIVATIVE;

ARTICLE; ASYMMETRIC CATALYSIS; CATALYST; CHLORINATION; ENANTIOMER; PRIORITY JOURNAL; SOLID;

EID: 27944473118     PISSN: 09574166     EISSN: 1362511X     Source Type: Journal    
DOI: 10.1016/j.tetasy.2005.09.014     Document Type: Article

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18. A standard chromatography column (1.3 cm inner diameter, 12 cm height) with a built-on jacket was used.
19. Wang resin VHL (100-200 mesh) was purchased from Novabiochem.
20. The beads can also be washed with methanol after the THF/Hünig's base wash and then dried under high vacuum at 120°C.
21. 5 have been synthesized previously.