Solid-phase synthesis of diaryl sulfides: Direct coupling of solid-supported aryl halides with thiols using an insoluble polymer-supported reagent

Organic Letters

Volumn 7, Issue 13, 2005, Pages 2719-2722

  Gendre, Fabrice ^a   Yang, Mathieu ^a   Diaz, Philippe ^a  

^a Galderma R and D   (France)

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EID: 27944456793     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol050939v     Document Type: Article

References (23)

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15. Provided by Mimotopes. http://www.mimotopes.com.
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18. For a typical procedure for coupling a carboxylic acid with SPPSLHMP lanterns, see Supporting Information.
19. For details concerning the LC/MS analyses, see Supporting Information.
20. For a typical procedure for coupling reaction of thiols, see Supporting Information.
21. For a typical procedure for coupling a carboxylic acid with SPPSLRAM lanterns, see Supporting Information.
22. For a typical procedure for coupling an alcohol with SPPSLHMP (0.16 μmol) SynPhase lanterns, see Supporting Information.
23. nBuOH/THF (1 mL per lantern) was stirred at 100°C for 15 h in a reactor fitted with a polypropylene gauze to avoid contact between SynPhase lanterns and resin. SynPhase lanterns were washed with THF (three times with 5 mL per lantern), EtOH (5 mL per lantern), and DCM (three times with 5 mL per lantern).