Hormonal regulation of growth plate cartilage

Hormone Research

Volumn 64, Issue SUPPL. 2, 2005, Pages 94-97

  Sävendahl, Lars ^a,b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Apoptosis; Cartilage; Chondrocyte; Growth hormone; Growth plate; IGF I; Oestrogen

Indexed keywords

ANDROGEN; AROMATASE; ESTROGEN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; GROWTH HORMONE; INSULIN; PARATHYROID HORMONE RELATED PROTEIN; SEX HORMONE; SOMATOMEDIN C; THYROID HORMONE;

APOPTOSIS; CARTILAGE; CARTILAGE CELL; CELL DIFFERENTIATION; CELL PROLIFERATION; CONFERENCE PAPER; ENCHONDRAL OSSIFICATION; ESTROGEN ACTIVITY; GROWTH PLATE; HORMONAL REGULATION; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PUBERTY;

ANDROGENS; ANIMALS; APOPTOSIS; BONE DEVELOPMENT; CHILD; ESTROGENS; GROWTH PLATE; HUMANS; MALE; SELECTIVE ESTROGEN RECEPTOR MODULATORS;

EID: 27944447373     PISSN: 03010163     EISSN: None     Source Type: Journal    
DOI: 10.1159/000087764     Document Type: Conference Paper

References (21)

1. Ohlsson C, Isaksson O, Lindahl A: Clonal analysis of rat tibia growth plate chondrocytes in suspension culture - differential effects of growth hormone and insulin-like growth factor I. Growth Regul 1994;4:1-7.
2. Sjögren K, Sheng M, Moverare S, Liu JL, Wallenius K, Tornell J, Isaksson O, Jansson JO, Mohan S, Ohlsson C: Effects of liver-derived insulin-like growth factor I on bone metabolism in mice. J Bone Miner Res 2002;17:1977-1987.
3. Wang J, Zhou J, Cheng CM, Kopchick JJ, Bondy CA: Evidence supporting dual, IGF-I-independent and IGF-I-dependent, roles for GH in promoting longitudinal bone growth. J Endocrinol 2004;180:247-255.
4. Karp SJ, Schipani E, St-Jacques B, Hunzelman J, Kronenberg H, McMahon AP: Indian hedgehog coordinates endochondral bone growth and morphogenesis via parathyroid hormone related-protein-dependent and -independent pathways. Development 2000;127:543-548.
5. Kindblom JM, Nilsson O, Hurme T, Ohlsson C, Sävendahl L: Expression and localization of Indian hedgehog (Ihh) and parathyroid hormone related protein (PTHrP) in the human growth plate during pubertal development. J Endocrinol 2002;174:R1-R6.
6. Chrysis D, Nilsson O, Ritzen EM, Sävendahl L: Apoptosis is developmentally regulated in rat growth plate. Endocrine 2002;18:271-278.
7. Chrysis D, Ritzen EM, Savendahl L: Growth retardation induced by dexamethasone is associated with increased apoptosis of the growth plate chondrocytes. J Endocrinol 2003;176:331-337.
8. Chrysis D, Zaman F, Chagin AS, Takigawa M, Sävendahl L: Dexamethasone induces apoptosis in proliferative chondrocytes through activation of caspases and suppression of the Akt-(PI3K) signalling pathway. Endocrinology 2005;146:1391-1397.
9. Weise M, De-Levi S, Barnes KM, Gafni RI, Abad V, Baron J: Effects of estrogen on growth plate senescence and epiphyseal fusion. Proc Natl Acad Sci USA 2001;98:6871-6876.
10. Ritzén EM, Nilsson O, Grigelioniene G, Holst M, Sävendahl L, Wroblewski J: Estrogens and human growth. J Steroid Biochem Mol Biol 2000;74:383-386.
11. van der Eerden BC, Karperien M, Wit JM: Systemic and local regulation of the growth plate. Endocr Rev 2003;24:782-801.
12. Conte FA, Grumbach MM, Fisher CR, Simpson ER: A syndrome of female pseudohermaphrodism, hyper-gonadotrophic hypogonadism, and multicystic ovaries associated with missense mutation in the gene encoding aromatase (P450arom). J Clin Endocrinol Metab 1994;78:1287-1292.
13. Smith EP, Boyd J, Frank GR, Takahashi H, Cohen RM, Specker B, Williams TC, Lubahn DB, Korach KS: Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. N Engl J Med 1994;331:1056-1061.
14. Attie KM, Ramirez NR, Conte FA, Kaplan SL, Grumbach MM: The pubertal growth spurt in eight patients with true precocious puberty and growth hormone deficiency: evidence for a direct role of sex steroids. J Clin Endocrinol Metab 1990;71:975-983.
15. Vidal O, Lindberg M, Sävendahl L, Korach K, Lubahn D, Ritzen EM, Gustafsson JÅ, Ohlsson C: Disproportional body growth in female estrogen receptor-alpha inactivated mice. Biochem Biophys Res Commun 1999;265:569-571.
16. Nilsson O, Abad V, Chrysis D, Ritzén EM, Sävendahl L, Baron J: Estrogen receptor-alpha and -beta are expressed throughout postnatal development in the rat and rabbit growth plate. J Endocrinol 2002;173:407-414.
17. Nilson O, Chrysis D, Pajulo O, Boman A, Holst M, Rubinstein J, Ritzén EM, Sävendahl L: Localization of estrogen receptor-alpha, -beta, and androgen receptor in the human growth plate at different pubertal stages. J Endocrinol 2003;177:319-326.
18. Chagin AC, Lindberg MK, Moverare S, Andersson N, Gustafsson J-Å, Sävendahl L, Ohlsson C: Estrogen receptor-beta inhibits skeletal growth and has the capacity to mediate growth plate fusion in female mice. J Bone Miner Res 2004;19:72-77.
19. Nilsson O, Falk J, Ritzén EM, Baron J, Sävendahl L: Raloxifene acts as an estrogen agonist on the rabbit growth plate. Endocrinology 2003;144:1481-1485.
20. Gunther DF, Underwood LE, Calikoglu AS: Androgen-accelerated bone maturation in mice is not attenuated by Faslodex, an estrogen receptor blocker. Bone 2001;28:410-413.
21. Tivesten Å, Movérare S, Chagin A, Venken K, Salmon P, Vanderschueren D, Sävendahl L, Holmäng A, Ohlsson C: Additive stimulatory effects of estrogen and androgen receptor activation on trabecular bone in ovariectomized rats. J Bone Miner Res 2004;19:1833-1839.