Gc protein (vitamin D-binding protein): Gc genotyping and GcMAF precursor activity

Anticancer Research

Volumn 25, Issue 6 A, 2005, Pages 3689-3695

  Nagasawa, Hideko ^a   Uto, Yoshihiro ^a   Sasaki, Hideyuki ^a   Okamura, Natsuko ^a   Murakami, Aya ^a   Kubo, Shinichi ^a   Kirk, Kenneth L ^b   Hori, Hitoshi ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

Alpha N acetylgalactosaminidase; Gc protein; Gc protein derived macrophage activating factor (GcMAF); Review

Indexed keywords

ALPHA N ACETYLGALACTOSAMINIDASE; ANGIOGENESIS INHIBITOR; ANGIOPOIETIN 2; ANTITHROMBIN III; BACTERIUM LIPOPOLYSACCHARIDE; BETA GALACTOSIDASE; CALCIFEDIOL; CD4 ANTIGEN; COMPLEMENT COMPONENT C5A; DENDRIMER; FIBROBLAST GROWTH FACTOR 2; G ACTIN; GAMMA INTERFERON; GC PROTEIN DERIVED MACROPHAGE ACTIVATING FACTOR; GLYCODENDRIPEPTIDE DERIVATIVE; LYSINE DERIVATIVE; MACROPHAGE ACTIVATING FACTOR; N ACETYLGLUCOSAMINE; NITRIC OXIDE; PEPTIDE DERIVATIVE; PHOTOFRIN; PHOTOSENSITIZING AGENT; PROTEIN PRECURSOR; SIALIDASE; SUPEROXIDE; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN A; VITAMIN D; VITAMIN D BINDING PROTEIN;

ALLELE; AMINO ACID SEQUENCE; ANTINEOPLASTIC ACTIVITY; BINDING SITE; CANCER ADJUVANT THERAPY; CARBOXY TERMINAL SEQUENCE; CELL ACTIVATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONFERENCE PAPER; DRUG DESIGN; DRUG EFFECT; DRUG TARGETING; ENZYME ACTIVITY; GENETIC RISK; GENOTYPE; HUMAN; INFLAMMATION; MACROPHAGE ACTIVATION; MOLECULAR CLONING; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OSTEOCLAST; PHOTODYNAMIC THERAPY; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; TUMOR REGRESSION;

AMINO ACID SEQUENCE; ANIMALS; DRUG DESIGN; GENOTYPE; HUMANS; MACROPHAGE-ACTIVATING FACTORS; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; VITAMIN D-BINDING PROTEIN;

EID: 27844593853     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (36)

1. White P and Cooke N: The multifunctional properties and characteristics of vitamin D-binding protein. Trends Endocrinol Metab 11: 320-327, 2000.
2. 3 binding protein (group-specific component) is a precursor for the macrophage-activating signal factor from lysophosphatidylcholine-treated lymphocytes. Proc Natl Acad Sci USA 88: 8539-8543, 1991.
3. Mohamad SB, Hori H, Nagasawa H, Usui K and Uto Y: Characterization of human Gc protein-derived macrophage activation factor (GcMAF) and its functional role in macrophage tumoricidal activity. Adv Exp Med Biol 510: 77-82, 2003.
4. Mohamad SB, Nagasawa H, Uto Y and Hori H: Preparation of Gc protein-derived macrophage activating factor (GcMAF) and its structural characterization and biological activities. Anticancer Res 22: 4297-4300, 2002.
5. Mohamad SB, Nagasawa H, Sasaki H, Uto Y, Nakagawa Y, Kawashima K and Hori H: Gc protein-derived macrophage activating factor (GcMAF): isoelectric focusing pattern and tumoricidal activity. Anticancer Res 23: 4451-4457, 2003.
6. Mohamad, SB, Nagasawa H, Uto Y and Hori H: Tumor cell alpha-N-acetylgalactosaminidase activity and its involvement in GcMAF-related macrophage activation. Comp Biochem Physiol A Mol Integr Physiol 132: 1-8, 2002.
7. Nakagawa Y, Sirivichayakul S, Phanuphak P, Suda T, Mito K and Hori H: Beneficial effect of macrophage activating agent NK-4 on Thai HIV-infected patients. Anticancer Res 23: 4389-4394, 2003.
8. Nagasawa H, Sasaki H, Uto Y, Kubo S and Hori H: Association of the macrophage activating factor (MAF) precursor activity with polymorphism in vitamin D-binding protein. Anticancer Res 24: 3361-3366, 2004.
9. Otterbein LR, Cosio C, Graceffa P and Dominguez R: Crystal structures of the vitamin D-binding protein and its complex with actin: structural basis of the actin-scavenger system. Proc Natl Acad Sci USA 99: 8003-8008, 2002.
10. Verboven C, Bogaerts I, Waelkens E, Rabijns A, Van Baelen H, Bouillon R and De Ranter C: Actin-DBP: the perfect structural fit? Acta Crystallogr D Biol Crystallogr 59: 263-273, 2003.
11. Head JF, Swamy N and Ray R: Crystal structure of the complex between actin and human vitamin D-binding protein at 2.5 A resolution. Biochemistry 41: 9015-9020, 2002.
12. Verboven C, Rabijns A, De Maeyer M, Van Baelen H, Bouillon R and De Ranter C: A structural basis for the unique binding features of the human vitamin D-binding protein. Nat Struct Biol 9: 131-136, 2002.
13. Cleve H and Constans J: The mutants of the vitamin D-binding protein: more than 120 variants of the GC/DBP system. Vox Sang 54: 215-225, 1988
14. Yang F, Brune JL, Naylor SL, Cupples RL, Naberhaus KH and Bowman BH: Human group-specific component (Gc) is a member of the albumin family. Proc Natl Acad Sci USA 82: 7994-7998, 1985.
15. Cooke NE and David EV: Serum vitamin D-binding protein is a third member of the albumin and alpha fetoprotein gene family. J Clin Invest 76: 2420-2424, 1985.
16. Braun A, Bichlmaier R and Cleve H: Molecular analysis of the gene for the human vitamin D-binding protein (group-specific component): allelic differences of the common genetic GC types. Hum Genet 89: 401-406, 1992.
17. Reynolds RL and Sensabough GF: Use of the polymerase chain reaction for typing Gc variants. In: Advances in Forensic Haemogenetics Vol. 3. Polesky HF and Mayr WR (eds.). Berlin, Springer-Verlag, pp. 158-161.
18. Yamamoto N: Macrophage activating factor from vitamin D-binding protein. US Patent 5,326,749, July 5, 1994.
19. 3 binding protein (group-specific component) is a precursor for the macrophage-activating signal factor from lysophosphatidylcholine-treated lymphocytes. Proc Natl Acad Sci USA 88: 8539-8543, 1991.
20. Ito I, Nagai S, Hoshino Y, Muro S, Hirai T, Tsukino M and Mishima M: Risk and severity of COPD is associated with the group-specific component of serum globulin IF allele. Chest 125: 63-70, 2004.
21. Joos L, Pare PD and Sandford AJ: Genetic risk factors of chronic obstructive pulmonary disease. Swiss Med Wkly 132: 27-37, 2002.
22. Schellenberg D, Pare PD, Weir TD, Spinelli JJ, Walker BA and Sandford AJ: Vitamin D binding protein variants and the risk of COPD. Am J Respir Crit Care Med 157: 957-961, 1998.
23. 3-binding protein leads to immunosuppression in cancer patients. Cancer Res 56: 2827-2831, 1996.
24. Yamamoto N, Naraparaju VR and Urade M: Prognostic utility of serum alpha-N-acetylgalactosaminidase and immunosuppression resulted from deglycosylation of serum Gc protein in oral cancer patients. Cancer Res 57: 295-299, 1997.
25. Yamamoto N and Naraparaju VR: Immunotherapy of BALB/c mice bearing Ehrlich ascites tumor with vitamin D-binding protein-derived macrophage activating factor. Cancer Res 57: 2187-2192, 1997.
26. Swamy N, Ghosh S, Schneider GB and Ray R: Baculovirus-expressed vitamin D-binding protein-macrophage activating factor (DBP-maf) activates osteoclasts and binding of 25-hydroxyvitamin D(3) does not influence this activity. J Cell Biochem 81: 535-546, 2001.
27. Korbelik M, Naraparaju VR and Yamamoto N: Macrophage-directed immunotherapy as adjuvant to photodynamic therapy of cancer. Br J Cancer 75: 202-207, 1997.
28. Koga Y, Naraparaju VR and Yamamoto N: Antitumor effect of vitamin D-binding protein-derived macrophage activating factor on Ehrlich ascites tumor-bearing mice. Proc Soc Exp Biol Med 220: 20-26, 1999.
29. Kanda S, Mochizuki Y, Miyata Y, Kanetake H and Yamamoto N: Effects of vitamin D(3)-binding protein-derived macrophage activating factor (GcMAF) on angiogenesis. J Natl Cancer Inst 94: 1311-1319, 2002.
30. Kisker O, Onizuka S, Becker CM, Fannon M, Flynn E, D'Amato R, Zetter B, Folkman J, Ray R, Swamy N and Pirie-Shepherd S: Vitamin D binding protein-macrophage activating factor (DBP-maf) inhibits angiogenesis and tumor growth in mice. Neoplasia 5: 32-40, 2003.
31. Onizuka S, Kawakami S, Taniguchi K, Fujioka H and Miyashita K: Pancreatic carcinogenesis: apoptosis and angiogenesis. Pancreas 28: 317-319, 2004.
32. 3-binding protein (group specific component, Gc) in lysophospholipid activation of mouse peritoneal macrophages. J Immunol 147: 273-280, 1991.
33. Korbelik M, Naraparaju VR and Yamamoto N: The value of serum alpha-N-acetylgalactosaminidase measurement for the assessment of tumour response to radio- and photodynamic therapy. Br J Cancer 77: 1009-1014, 1998.
34. Matsuura T, Uematsu T, Yamaoka M and Furusawa K: Effect of salivary gland adenocarcinoma cell-derived alpha-N-acetylgalactosaminidase on the bioactivity of macrophage activating factor. Int J Oncol 24: 521-528, 2004.
35. Schneider GB, Grecco KJ, Safadi FF and Popoff SN: The anabolic effects of vitamin D-binding protein-macrophage activating factor (DBP-MAF) and a novel small peptide on bone. Crit Rev Eukaryot Gene Expr 13: 277-284, 2003.
36. Kasai S, Nagasawa H, Shimamura M, Uto Y and Hori H: Design and synthesis of antiangiogenic/heparin-binding arginine dendrimer mimicking the surface of endostatin. Bioorg Med Chem Lett 12: 951-954, 2002.