Synthesis and radioiodination of some 9-aminoacridine derivatives for potential use in radionuclide therapy

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 48, Issue 12, 2005, Pages 855-871

  Ghirmai, Senait ^a   Mume, Eskender ^a   Lundqvist, Hans ^b   Tolmachev, Vladimir ^a,b   Sjöberg, Stefan ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

9 aminoacridine derivatives; 125I; Chloramine T; Radioiodination

Indexed keywords

BIOACTIVITY; PROPIONIC ACID;

125I; 9-AMINOACRIDINE DERIVATIVE; BIOLOGICAL EXPERIMENTS; CHLORAMINE-T; DNA-INTERCALATING COMPOUNDS; PALLADIUM-CATALYZED REACTIONS; RADIOIODINATION; RADIONUCLIDE THERAPY; SYNTHESISED;

PHENOLS;

3 [4 [3 (ACRIDIN 9 YLAMINO)PROPOXY] 3 TRIMETHYLSTANNYLPHENYL]PROPIONIC ACID; 4 [2 (ACRIDIN 9 YLAMINO)ETHYL]PHENOL; ACRIDIN 9 YL [3 [4 (2 AMINOETHYL) 2 TRIMETHYLSTANNYLPHENOXY]PROPYL]AMINE; AMINOACRIDINE DERIVATIVE; INTERCALATING AGENT; IODINE 125; IODINE DERIVATIVE; OXIDIZING AGENT; PALLADIUM; PHENOL DERIVATIVE; PROPIONIC ACID DERIVATIVE; RADIOISOTOPE; TIN DERIVATIVE; TOSYLCHLORAMIDE SODIUM; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CATALYSIS; ISOTOPE LABELING; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTUM YIELD; RADIOCHEMISTRY; RADIOIODINATION; REACTION ANALYSIS;

EID: 27844585500     PISSN: 03624803     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlcr.960     Document Type: Article

References (18)

1. Zwelling L, Michaels S, Erickson L, Ungerleider R, Nichols M, Kohn K. Biochemistry 1981; 20: 6553-6563.
2. Baguley B, Denny W, Atwell G, Cain B. J Med Chem 1981; 24: 170-177.
3. Lerman LS. J Mol Biol 1961; 3: 18-30.
4. Wirth M, Buchardt O, Koch T, Nielsen P, Norden B. J Am Chem Soc 1988; 110: 932-939.
5. Crenshaw J, Graves D, Denny W. Biochemistry 1995; 34: 13682-13687.
6. Belmont P, Jourdan M, Demeunynck M, Constant J, Garcia J, Lhomme J. J Med Chem 1999; 42: 5153-5159.
7. Denny WA, Atwell GJ, Baguley BC. J Med Chem 1983; 26: 1619-1625.
8. Phanstiel O, Price HL, Wang L, Juusola J, Kline M, Shah S. J Org Chem 2000; 65: 5590-5599.
9. Carlsson J, Kullberg E, Capala J, Sjöberg S, Edwards K, Gedda L. J Neuro-Oncol 2003; 62: 47-59.
10. Gedda L, Carlsson J. Int J Oncol 1997; 11: 789-797.
11. Bohl E, Bergstrand N, Carlsson J, Edwards K, Johnsson M, Sjöberg S, Gedda L. Bioconjugate Chem 2002; 13: 737-743.
12. Ghirmai S, Mume E, Tolmachev V, Sjöberg S. Eur J Org Chem 2004; 17: 3719-3725.
13. Dupre DJ, Robinson FA. J Chem Soc 1945; 549-551.
14. Ghaneolhosseni H, Tjarks W, Sjöberg S. Tetrahedron 1998; 54: 3877-3884.
15. Espuna G, Arsequell G, Valencia G, Barluenga J, Perez M, Gonzalez J. Chem Commun 2000; 14: 1307-1308.
16. Counsell RE, Smith TD, Ranade VV, Noronha OPD, Desai P. J Med Chem 1973; 16: 684-687.
17. Greene TW, Wuts PGM. Protecting Groups in Organic Synthesis (3rd edn). Wiley: New York, 1999; 518-522.
18. Herbert JM, Hewson AT, Peace JE. Synthetic Commun 1998; 28: 823-832.