Significance of occult lymphatic tumor spread in pancreatic cancer;Okkulte lymphatische tumorzelldisseminierung beim pankreaskarzinom

Chirurg

Volumn 76, Issue 11, 2005, Pages 1064-1072

  Milsmann, C ^a   Fuzesi L ^a   Werner, C ^a   Becker, H ^a   Horstmann, O ^a  

^a UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

Author keywords

Occult tumor cells lymph node metastasis; Pancreatic cancer

Indexed keywords

AGED; ARTICLE; BILE DUCT TUMOR; CANCER STAGING; DISEASE COURSE; FEMALE; HUMAN; LYMPH NODE; LYMPH NODE METASTASIS; LYMPHADENECTOMY; MALE; MIDDLE AGED; PAGET NIPPLE DISEASE; PANCREAS RESECTION; PANCREAS TUMOR; PATHOLOGY; PROGNOSIS; SURVIVAL; VATER PAPILLA;

AGED; AMPULLA OF VATER; CARCINOMA, DUCTAL; COMMON BILE DUCT NEOPLASMS; DISEASE PROGRESSION; FEMALE; HUMANS; LYMPH NODE EXCISION; LYMPH NODES; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM STAGING; PANCREATECTOMY; PANCREATIC NEOPLASMS; PROGNOSIS; SURVIVAL ANALYSIS;

EID: 27844574203     PISSN: 00094722     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00104-005-1041-y     Document Type: Article

References (33)

1. Kayahara M, Nagakawa T, Ueneo K, Ohta T, Takeda T, Miyazaki I (1993) An evaluation of radical resection for pancreatic cancer based on the mode of recurrence by autopsy and diagnostic imaging. Cancer 72:2118-2123
2. Geer RJ, Brennan MF (1993) Prognostic indicators of survival after resection of pancreatic adenocarcinoma. Am J Surg 165:68-72
3. UICC (2002) Pancreas. In: Sobin LH, Wittekind (Hrsg) TNM classification of malignant tumors. 6th edn. Wiley-Liss, New York, S 93-96
4. Hermanek P, Hutter P, Sobin L, Wittekind K (1999) Classification of isolated tumor cells and micrometastasis. Cancer 86:2668-26743
5. Pantel K (2001) Micrometastasis. In: Schwab M (Hrsg) Encyclopedic reference of cancer. Springer, Berlin Heidelberg, S 567-571
6. Dobashi K, Sugio K, Osaki T, Oka T, Yasumoto K (1997) Micrometastatic p53-positive cells in the lymph nodes of non-small cell lung cancer: prognostic relevance. J Thorac Cardiovasc Surg 114:339-46
7. Adell G, Boeryd B, Franlund B, Sjördahl R, Hakansson L (1996) Occurrence and prognostic importance of micrometastases in regional lymph nodes in Dukes' B colorectal carcinoma: An immunohistochemical study. Eur J Cancer 162:637-642
8. Broll R, Schauer V, Schimmelpenning H et al. (1997) Prognostic relevance of occult tumor cells in lymph nodes of colorectal carcinomas: An immunohistochemical study. Dis Colon Rectum 40:1465-71
9. Izbicki JR, Hosch SB, Pichlmeier U et al. (1997) Prognostic value of immunohistochemically identifiable tumor cells in lymph nodes of patients with complete resected esophageal cancer. N Engl J Med 337:1188-1194
10. Horstmann O, Füzesi L, Markus PM, Werner C, Becker H (2004) Significance of isolated tumor cells in lymph nodes among gastric cancer patients, J Cancer Res Clin Oncol 130:733-740
11. Ridwelski K, Meyer F, Fahlke J, Kasper U, Roessner A, Lippert H (2001) Stellenwert von Cytokeratin-und CA19-9-Antigen im immunhistologischen Nachweis disseminierter Tumorzellen in Lymphknoten beim Pancreaskarzinom. Chirurg 72:920-926
12. Hosch SB, Knoefel WT, Metz S, Stoecklein N, Neindorf A, Broelsch CE, Izbicki J (1997) Early lymphatic tumor cell dissemination in pancreatic cancer: Frequency and prognostic significance. Pancreas 15:154-159
13. Hermanek P (1998) Pathology and biology of pancreatic ductal adenocarcinoma. Langenbecks Arch Surg 383:116-120
14. Junginger T (1999) Leitlinie: Diagnostik und Therapie des exokrinen Pankreaskarzinoms. In: Junginger T, Hossfeld DK, Müller RP (Hrsg) Leitlinien zur Diagnostik und Therapie von Tumoren des Gastrointestinaltraktes und der Schilddrüse. Demeter, Stuttgart, S 118
15. Turner RR, Ollila DW, Stern S, Giuliano AE (1999) Optimal histopathologic examination of the sentinel lymph node for breast carcinoma staging. Am J Surg Pathol 23:263-267
16. Domagala W, Bedner E, Chosia M (1991) Keratin-positive reticulum cells in fine needle aspirates and touch imprints of hyperplastic lymph nodes. Acta Cytol 36:241-251
17. Traweek ST, Liu J, Battifora H (1993) Keratin gene expression in non-epithelial tissues. Am J Pathol 142:1111-1118
18. Pantel K, Schlimok G, Angstwurm M et al. (1994) Methodological analysis of immunocytochemical screening for disseminated epithelial tumor cells in bone marrow. J Haematother 3:165-73
19. Jung R, Petersen K, Krüger W, Wolf M, Wagener C, Zander A, Neumaier M (1999) Detection of micrometastasis by cytokeratin 29 RT-PCR is limited due to stable background transcription in granulocytes. Br J Cancer 81:870-873
20. Passlick B, Izbicki JR, Kubuschok B et al. (1994) Immunohistochemical assessment of individual tumour cells in lymph nodes of patients with non-small cell lung cancer. J Clin Oncol 12:1827-1832
21. Izbicki JR, Hosch SB, Pichlmeier U et al. (1997) Prognostic value of immunohistochemically identifiable tumor cells in lymph nodes of patients with complete resected esophageal cancer. N Engl J Med 337:1188-1194
22. Latza U, Niedobitek G, Schwarting R, Nekarda H, Stein H (1990) Ber-Ep4: New monoclonal antibody which distinguishes epithelia from mesothelia. J Clin Pathol 43:213-219
23. Momburg F, Moldenhauer G, Hämmerling GJ, Möller P (1987) Immunohistochemical study of the expression of a Mr 34,000 human epithelium-specific surface glycoprotein in normal and malignant tissue. Cancer Res 47:2883-2891
24. Ando N, Nakao A, Nomoto S et al. (1997) Detection of Mutant K-Ras in Dissected Paraaortic Lymph Nodes of Patients with Pancreatic Adenocarcinoma. Pancreas 15:374-378
25. Tamagawa E, Ueda M, Takahashi S et al. (1997) Pancreatic Lymph Nodal and plexus Micrometastases Detected by Enriched Polymerase Chain Reaction and Nonradioisotopic Single-Strand Conformation Polymorphism Analysisi: A New Predictive Factor for Recurrent Pancreatic Carcinoma. Clin Cancer Res 3:2143-2149
26. Demeure MJ, Doffek KM, Komorowski RA et al. (1998) Molecular metastases in stage I pancreatic cancer: Improved survival with adjuvant chemoradiation. Surgery 124:663-669
27. Yamaguchi K, Chijiiwa K, Torato N, Kinoshita M, Tanaka M (2000) Ki-Ras Codon 12 Point and P53 mutations: A Molecular Examination of the Main Tumor, Liver portal vein, Peripheral Arterial Blood and Para-Aortic Lymph Node in Pancreatic Cancer. Am J Gastroenterology 95:1939-1945
28. Yamada T, Nakamori S, Ohzato H et al. (2000) Outcome of pancreatic cancer patients based on genetic lymph node staging. Int J Onc 16:1165-1171
29. Niedergethmann M, Rexin M, Hildenbrand R, Knob S, Sturm J, Richter A, Post S (2002) Prognostic implications of routine, immunohistochemical, and molecular staging in resectable pancreatic adenocarcinoma. Am J Surg Path 26:1578-1587
30. Kanemitsu K, Hiraoka T, Tsuji T, Inoue K, Yakamori H (2003) Implication of Micrometastases of Lymph Nodes in Patients With Extended Operation For Pancreatic cancer. Pancreas 26:315-321
31. Bogoevski D, Yekebas EF, Schurr P et al. (2004) Mode of spread in the early phase of lymphatic metastasis in pancreatic ductal adenocarcinoma. Prognostic significance of nodal microinvolvement. Ann Surg 240:993-1001
32. Fukagawa M, Sasako M, Mann GB et al. (2001) Immunohistochemically detected micrometastases of the lymph nodes in patients with gastric carcinoma. Cancer 92:753-760
33. Yeo CJ, Cameron JL, Sohn TA et al. (1997) Six hundred fifty consecutive pancreaticoduodenectomies in the 1990s. Ann Surg 226:248-260