CEBPG transcription factor correlates with antioxidant and DNA repair genes in normal bronchial epithelial cells but not in individuals with bronchogenic carcinoma_aptad 20050829

BMC Cancer

Volumn 5, Issue , 2005, Pages

  Mullins, D'Anna N ^a   Crawford, Erin L ^a   Khuder, Sadik A ^a   Hernandez, Dawn Alita ^a   Yoon, Youngsook ^a   Willey, James C ^a  

^a MEDICAL COLLEGE OF OHIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; EXCISION REPAIR CROSS COMPLEMENTING PROTEIN 1; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR E2F1; CCAAT ENHANCER BINDING PROTEIN; CCAAT ENHANCER BINDING PROTEIN GAMMA; CCAAT-ENHANCER-BINDING PROTEIN-GAMMA; COPPER ZINC SUPEROXIDE DISMUTASE; DNA BINDING PROTEIN; DNA EXCISION REPAIR PROTEIN ERCC 5; DNA EXCISION REPAIR PROTEIN ERCC-5; ENDONUCLEASE; GLUTATHIONE PEROXIDASE; GLUTATHIONE PEROXIDASE 1; GLUTATHIONE TRANSFERASE P1; GSTP1 PROTEIN, HUMAN; NUCLEAR PROTEIN; SUPEROXIDE DISMUTASE; X-RAY REPAIR CROSS COMPLEMENTING PROTEIN 1; XRCC1 PROTEIN;

ADULT; AGED; ARTICLE; BRONCHUS MUCOSA; CANCER RISK; CIGARETTE SMOKING; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA SEQUENCE; EPITHELIUM CELL; FEMALE; GENE EXPRESSION REGULATION; GENE FUNCTION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; INDIVIDUALIZATION; LUNG CARCINOMA; MALE; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; QUANTITATIVE ANALYSIS; RISK ASSESSMENT; SEQUENCE ANALYSIS; TRANSCRIPTION REGULATION; BINDING SITE; BIOSYNTHESIS; BRONCHUS; BRONCHUS TUMOR; CARCINOMA; CYTOLOGY; DNA REPAIR; GENETICS; METABOLISM; MIDDLE AGED; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEX DIFFERENCE; SMOKING; STATISTICAL MODEL;

ADULT; AGED; AGED, 80 AND OVER; ANTIOXIDANTS; BINDING SITES; BRONCHI; BRONCHIAL NEOPLASMS; CARCINOMA; CCAAT-ENHANCER-BINDING PROTEINS; DNA REPAIR; DNA-BINDING PROTEINS; ENDONUCLEASES; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUTATHIONE PEROXIDASE; GLUTATHIONE S-TRANSFERASE PI; HUMANS; MALE; MIDDLE AGED; MODELS, STATISTICAL; NUCLEAR PROTEINS; POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEX FACTORS; SMOKING; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 27844554852     PISSN: 14712407     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-5-141     Document Type: Article

References (27)

1. Weitberg AB: Cancer of the Lung: from molecular biology to treatment guidelines. Totowa: Humana Press, Inc.; 2002.
2. Baldwin PD: Lung Cancer. ClinJOncolNurs 2003, 7(6):699-702.
3. Page GP, Green JL, Lackland D: Epidemiology of lung cancer with special reference to genetics, bioassays, women, and developing countries. Semin Respir Crit Care Med 2000, 21(5):365-374.
4. Anttila S, Hirvonen A, Vainio H, Husgafvel-Pursiainen K, Hayes JD, Ketterer B: Immunohistochemical localization of glutathione S-transferases in human lung. Cancer Res 1993, 53(23):5643-5648.
5. Chu F, Esworthy RS, Doroshow JH, Doan K, Liu X: Expression of plasma glutathione peroxidase in human liver in addition to kidney, heart, lung, and breast in humans and rodents. Blood 1992, 79(12):3233-3238.
6. Ketterer B, Harris JM, Talaska G, Meyer DJ, Pemble SE, Taylor JB, Lang NP, Kadlubar FF: The human glutathione S-transferase supergene family, its polymorphism, and its effects on susceptibility to lung cancer. Environ Health Perspect 1992, 98:87-94.
7. Freeman BA, Crapo JD: Biology of disease: free radicals and tissue injury. LabInvest 1982, 47(5):412-426.
8. Seeberg EE, L.; Bjorts,M.: The base excision repair pathway. Trends in Biochemical Sciences 1995, 20(10):391-397.
9. Crawford EL, Khuder SA, Durham SJ, Frampton M, Utell M, Thilly WG, Weaver DA, Ferencak WJ, Jennings CA, Hammersley JR et al: Normal bronchial epithelial cell expression of glutathione transferase P1, glutathione transferase M3, and glutathione peroxidase is low in subjects with bronchogenic carcinoma. Cancer Res 2000, 60:1609-1618.
10. Zhong X, Thornton K, Reed E: Computer based analyses of the 5′-flanking regions of selected genes involved in the nucleotide excision repair complex. International Journal of Oncology 2000, 17:375-380.
11. Crawford EL, Warner KA, Khuder SA, Zahorchak RJ, Willey JC: Multiplex standardized RT-PCR for expression analysis of many genes in small samples. Biochemical and Biophysical Research Communications 2002, 293:509-516.
12. Willey JC, Coy E, Brolly C, Utell MJ, Frampton MW, Hammersley JR, Thilly WG, Olson DA, Cairns K: Xenobiotic metabolism enzyme gene expression in human bronchial epithelial and alveolar macrophage cells. AmJRespCell MolBiol 1996, 14:262-271.
13. Willey JC, Crawford EL, Knight CR, Warner KA, Motten CA, Herness EA, Zahorchak RJ, Graves TG: Gene expression profiling: methods and protocols- "Standardized RT-PCR and the Standardized Expression Measurement Center. In: Methods in Molecular Biology. Edited by Shimkets RA, 258 edn. Totowa: Humana Press, Inc.; 2004.
14. Willey JC: Quality-controlled multi-gene expression measurement: an essential tool for the development of drugs and diagnostic tests. In: PharmaGenomics. Edited by Arzimanoglou I, Balough M, Bonn G, Cohen D, Dishman R, Finkelstein S, Foster C, Logan GW, Porcella A, Regnier FE et al, vol. 2004, January 2004 edn: Advanstar Communications; 2004: 20-33.
15. Willey JC, Crawford EL, Knight CR, Warner KA, Motten CA, Herness EA, Zahorchak RJ, Graves TG: Standardized RT-PCR and the Standardized Expression Measurement Center. In: Methods in Molecular Biology. Edited by Shimkets RA, vol. 258. Totowa: Humana Press, Inc; 2004: 13-41.
16. Workman J, Mark H: Comparison of Goodness of Fit Statistics for Linear Regression, Part I. Spectroscopy 2004, 19(4):38-41.
17. GmbH GS: http://genomatix.de/cgi-bin/eldorado/.
18. Quandt K, Frech K, Karas H, Wingender E, Werner T: MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data. Nucleic Acids Res 1995, 23(23):4878-4884.
19. Johnson PF, Williams SC. In: Liver Gene Expression. Edited by Yaniv M, Tronche F. Austin: R.G. Landes Company; 1994: 231-258.
20. Cooper C, Henderson A, Artandi S, Avitahl N, Calame K: Ig/EBP (C/EBP gamma) is a transdominant negative inhibitor of C/EBP family transcriptional activators. Nucleic Acids Res 1995, 23(21):4371-4377.
21. Gao H, Parkin S, Johnson PF, Schwartz RC: C/EBP gamma has a stimulatory role on the IL-6 and IL-8 promoters. J Biol Chem 2002, 277(41):38827-38837.
22. Kaisho T, Tsutsui H, Tanaka T, Tsujimura T, Takeda K, Kawai T, Yoshida N, Nakanishi K, Akira S: Impairment of natural killer cytotoxic activity and interferon gamma production in CCAAT/enhancer binding protein gamma-deficient mice. J Exp Med 2005, 190(11):1573-1582.
23. Repine JE, Bast A, Lankhorst I: Oxidative stress in chronic obstructive pulmonary disease. Oxidative Stress Study Group. AmJRespirCritCare Med 1997, 156:341-357.
24. Ren B, Cam H, Takahashi Y, Volkert T, Terragni J, Young RA, Dynlacht BD: E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints. Genes Dev 2002, 16(2):245-256.
25. Berton TR, Mitchell DL, Guo R, Johnson DG: Regulation of epidermal apoptosis and DNA repair by E2F1 in response to ultraviolet B radiation. Oncogene 2005, 24(15):2449-2460.
26. Caporaso NE: Why have we failed to find the low penetrance genetic constituents of common cancers? Cancer Epidemiol Biomarkers Prev 2002, 11(12):1544-1549.
27. Xi T, Jones IM, Mohrenweiser HW: Many amino acid substitution variants identified in DNA repair genes during human population screenings are predicted to impact protein function. Genomics 2004, 83(6):970-979.