Low dose aerosol infection of mice with virulent type A Francisella tularensis induces severe thymus atrophy and CD4+CD8+ thymocyte depletion

Microbial Pathogenesis

Volumn 39, Issue 5-6, 2005, Pages 189-196

  Chen, Wangxue ^a   Kuolee, Rhonda ^a   Austin, John W ^b   Shen, Hua ^a   Che, Yanming ^a,c   Conlan, J Wayne ^a  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^b HEALTH CANADA   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Francisella tularensis; Host response; Mouse model; Pathogenesis; Thymus

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CORTISONE; FAS LIGAND; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 2;

ADRENALECTOMY; AIRBORNE INFECTION; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; CELL DESTRUCTION; CONTROLLED STUDY; CORTICOSTEROID BLOOD LEVEL; DISEASE SEVERITY; EXPERIMENTAL INFECTION; FRANCISELLA TULARENSIS; GRAM NEGATIVE BACTERIUM; IMMUNE RESPONSE; LYMPHOCYTE DEPLETION; MOUSE; NONHUMAN; ORGAN WEIGHT; PATHOGENESIS; PRIORITY JOURNAL; THYMOCYTE; THYMUS ATROPHY; TULAREMIA;

ADRENAL GLANDS; ADRENALECTOMY; AEROSOLS; ANIMALS; ANTIGENS, CD4; ANTIGENS, CD8; CORTISONE; FAS LIGAND PROTEIN; FEMALE; FLOW CYTOMETRY; FRANCISELLA TULARENSIS; LYMPHOCYTE SUBSETS; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, TUMOR NECROSIS FACTOR; SIGNAL TRANSDUCTION; THYMUS GLAND; TULAREMIA; TUMOR NECROSIS FACTOR-ALPHA; TUMOR NECROSIS FACTORS;

ANIMALIA; BACTERIA (MICROORGANISMS); FRANCISELLA TULARENSIS; MAMMALIA; NEGIBACTERIA;

EID: 27844536449     PISSN: 08824010     EISSN: 10961208     Source Type: Journal    
DOI: 10.1016/j.micpath.2005.08.005     Document Type: Article

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