Integrated expressional analysis: Application to the drug discovery process

Methods

Volumn 37, Issue 3, 2005, Pages 280-288

  Ilyin, Sergey E ^a   Horowitz, Daniel ^a   Belkowski, Stanley M ^a   Xin, Hong ^a   Eckardt, Annette J ^a   Darrow, Andrew L ^a   Chen, Cailin ^a   Maley, Derrick ^a   D'Andrea, Michael ^a   Plata Salamán, Carlos R ^a,b   Derian, Claudia K ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

Biomarkers; Functional informatics; Gene expression; High content; Multiplex; RT PCR; siRNA; TaqMan; Target validation; Toxicity

Indexed keywords

BIOLOGICAL MARKER; MESSENGER RNA;

ARTICLE; BIOLOGY; CELL POPULATION; CELL VIABILITY; CENTRAL NERVOUS SYSTEM; CYTOLOGY; DNA MICROARRAY; DRUG ABSORPTION; DRUG DISPOSITION; DRUG ELIMINATION; GENE EXPRESSION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IMAGING; MEDICAL RESEARCH; MEDICAL TECHNOLOGY; METABOLISM; NERVE CELL; NEUROSCIENCE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN ANALYSIS; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCREENING; TOXICITY; VALIDATION PROCESS;

DRUG EVALUATION, PRECLINICAL; DRUG INDUSTRY; GENE EXPRESSION PROFILING; GREEN FLUORESCENT PROTEINS; HUMANS; MICROSCOPY, CONFOCAL; PROTEIN ARRAY ANALYSIS; PROTEIN KINASE C; PROTEIN TRANSPORT; RECOMBINANT PROTEINS; REPRODUCIBILITY OF RESULTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 27844458022     PISSN: 10462023     EISSN: 10959130     Source Type: Journal    
DOI: 10.1016/j.ymeth.2005.03.013     Document Type: Article

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