Duodenal Dcytb and hephaestin mRNA expression are not significantly modulated by variations in body iron homeostasis

Blood Cells, Molecules, and Diseases

Volumn 35, Issue 3, 2005, Pages 303-308

  Gleeson, F ^a   Ryan, E ^a   Barrett, S ^a   Russell, J ^a   Kelleher, B ^a   Crowe, J ^a  

^a MATER MISERICORDIAE UNIVERSITY HOSPITAL   (Ireland)

Author keywords

Duodenal Dcytb; Duodenal hephaestin; HFE associated hemochromatosis; Iron deficiency anemia; Iron homeostasis

Indexed keywords

CERULOPLASMIN; CYTOCHROME B; FERRITIN; HEPHAESTIN; IRON; MESSENGER RNA; UNCLASSIFIED DRUG;

ARTICLE; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DUODENUM MUCOSA; FEMALE; FERRITIN BLOOD LEVEL; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC CORRELATION; HOMOZYGOSITY; HUMAN; HUMAN TISSUE; IRON ABSORPTION; IRON BLOOD LEVEL; IRON DEFICIENCY ANEMIA; IRON DEPLETION; IRON TRANSPORT; MALE; PHLEBOTOMY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SIDEROSIS;

CERULOPLASMIN; COHORT STUDIES; CYTOCHROME B GROUP; DUODENUM; FEMALE; FMN REDUCTASE; GENE EXPRESSION REGULATION; HEMOCHROMATOSIS; HUMANS; IRON; MALE; MEMBRANE PROTEINS; MIDDLE AGED; MUTATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; VARIATION (GENETICS);

EID: 27744606071     PISSN: 10799796     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcmd.2005.06.005     Document Type: Article

References (24)

1. K. Yeh, M. Yeh, and J. Glass Hepcidin regulation of ferroportin 1 expression in the liver and intestine of the rat Am. J. Physiol.: Gastrointest. Liver Physiol. 286 2004 G385 G394
2. S. Ludwiczek, I. Theurl, S. Bahram, K. Schumann, and G. Weiss Regulatory networks for the control of body iron homeostasis and their dysregulation in HFE mediated hemochromatosis J. Cell. Physiol. 204 2 2005 489 499
3. A. McKie, P. Marciani, A. Rolfs, K. Brennan, K. Wehr, and D. Barrow A novel duodenal iron regulated transporter, IREG1, implicated in the basolateral transfer of iron in the circulation Mol. Cell 5 2000 299 309
4. C.D. Vulpe, Y.M. Kuo, T.L. Murphy, L. Cowley, C. Askwith, and N. Libina Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse Nat. Genet. 21 2 1999 Feb. 195 199
5. T. Kelleher, E. Ryan, S. Barrett, M. Sweeney, V. Byrnes, C. O'Keane, and J. Crowe Increased DMT1 but not IREG1 or HFE mRNA following iron depletion therapy in hereditary haemochromatosis Gut 53 8 2004 Aug. 1174 1179
6. K. Takeuchi, I. Bjarnason, A.H. Laftah, G.O. Latunde-Dada, R.J. Simpson, and A.T. McKie Expression of iron absorption genes in mouse large intestine Scand J Gastroenterol. 40 2 2005 Feb. 169 177
7. G. Latunde-Dada, J. Van der Westhuizen, C. Vulpe, G. Anderson, R. Simpson, and A. McKie Molecular and functional roles of duodenal cytochrome B (Dcytb) in iron metabolism Blood Cells Mol. Dis. 29 3 2002 Nov. 356 360
8. K.N. Millard, C.M. Frazer, S.J. Wilkins, and G.J. Anderson Changes in the expression of intestinal iron transport and hepatic iron regulatory molecules explain the enhanced iron absorption associated with pregnancy in the rat Gut. 53 5 2004 May 655 660
9. L. Viatte, J.C. Lesbordes-Brion, D.Q. Lou, M. Bennoun, G. Nicolas, and A. Kahn Deregulation of proteins involved in iron metabolism in hepcidin-deficient mice Blood 2005 Feb. 15 (0: 200412460)
10. D. Frazer, S. Wilkins, E. Becker, C. Vulpe, A. McKie, and D. Trinder Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats Gastroenterology 123 3 2002 Sep. 835 844
11. H. Chen, Z.K. Attieh, T. Su, B.A. Syed, H. Gao, and R.M. Alaeddine Hephaestin is a ferroxidase that maintains partial activity in sex-linked anemia mice Blood 103 10 2004 May 15 3933 3939
12. T. Herrmann, M. Muckenthaler, F. van der Hoeven, K. Brennan, S. Gehrke, and N. Hu Iron overload in adult HFE-deficient mice independent of changes in the steady-state expression of the duodenal iron transporters DMT1 and Ireg1/ferroportin J. Mol. Med. 82 1 2004 Jan. 39 48
13. M.U. Muckenthaler, P. Rodrigues, M.G. Macedo, B. Minana, K. Brennan, and E.M. Ardoso Molecular analysis of iron overload in beta2-microglobulin-deficient mice Blood Cells Mol Dis. 33 2 2004 Sep.-Oct. 125 131
14. R.E. Fleming, and W.S. Sly Hepcidin: a putative iron-regulatory hormone relevant to hereditary hemochromatosis and the anemia of chronic disease Proc. Natl. Acad. Sci. U. S. A. 98 15 2001 Jul. 17 8160 8162
15. G.J. Anderson, D.M. Frazer, S.J. Wilkins, E.M. Becker, K.N. Millard, and T.L. Murphy Relationship between intestinal iron-transporter expression, hepatic hepcidin levels and the control of iron absorption Biochem. Soc. Trans. 30 4 2002 Aug. 724 726
16. D.M. Frazer, C.D. Vulpe, A.T. McKie, S.J. Wilkins, D. Trinder, and C.G. Cleghorn Cloning and gastrointestinal expression of rat hephaestin: relationship to other iron transport proteins Am. J. Physiol. Gastrointest Liver. Physiol. 281 4 2001 Oct. G931 G939
17. S. Sakakibara, and Y. Aoyama Dietary iron-deficiency up-regulates hephaestin mRNA level in small intestine of rats Life Sci. 70 26 2002 May 17 3123 3129
18. H. Chen, T. Su, Z.K. Attieh, T.C. Fox, A.T. McKie, and G.J. Anderson Systemic regulation of hephaestin and Ireg1 revealed in studies of genetic and nutritional iron deficiency Blood 102 5 2003 Sep. 1 1893 1899
19. H. Zoller, I. Theurl, R.O. Koch, A.T. McKie, W. Vogel, and G. Weiss Duodenal cytochrome b and hephaestin expression in patients with iron deficiency and hemochromatosis Gastroenterology. 125 3 2003 Sep. 746 754
20. K. Stuart, G. Anderson, D. Frazer, L. Powell, M. McCullen, and L. Fletcher Duodenal expression of iron transport molecules in untreated haemochromatosis subjects Gut 52 2003 953 959
21. D. Barisani, S. Ceroni, S. Del Bianco, R. Meneveri, and M.T. Bardella Hemochromatosis gene mutations and iron metabolism in celiac disease Haematologica 89 11 2004 Nov. 1299 1305
22. A. Rolfs, H.L. Bonkovsky, J.G. Kohlroser, K. McNeal, A. Sharma, and U.V. Berger Intestinal expression of genes involved in iron absorption in humans Am. J. Physiol.: Gastrointest. Liver Physiol. 282 4 2002 Apr. G598 G607
23. M. Muckenthaler, C.N. Roy, A.O. Custodio, B. Minana, J. deGraaf, and L.K. Montross Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis Nat. Genet. 34 1 2003 May 102 107
24. D. Frazer, S. Wilkins, E. Becker, T. Murphy, C. Vulpe, and A. McKie A rapid decrease in the expression of DMT1 and Dcytb but not IREG1 or hephaestin explains the mucosal block phenomenon of iron absorption Gut 52 2003 340 346