Pathophysiology of acne;Pathophysiologie der akne

Hautarzt

Volumn 56, Issue 11, 2005, Pages 1013-1017

  Borelli, C ^a   Plewig, G ^a   Degitz, K ^a,b  

^a UNIVERSITY OF MUNICH   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Acne; Propionibacterium acnes; Seborrhea; Toll like receptor

Indexed keywords

ACNE; ARTICLE; DARIER DISEASE; HUMAN; INFLAMMATION; PATHOGENESIS; PROPIONIBACTERIUM; SEBORRHEA;

ACNE VULGARIS; DERMATITIS; HUMANS; HYPERKERATOSIS, EPIDERMOLYTIC; PROPIONIBACTERIUM ACNES;

EID: 27744527298     PISSN: 00178470     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00105-005-1043-1     Document Type: Article

References (33)

1. Allaker RP, Greenman J, Osborne RH (1987) The production of inflammatory compounds by Propionibacterium acnes and other skin organisms. Br J Dermatol 117:175-183
2. Choudhry R, Hodgins MB, Van der Kwast TH et al. (1992) Localization of androgen receptors in human skin by immunohistochemistry: implications for the hormonal regulation of hair growth, sebaceous glands and sweat glands. J Endocrinol 133:467-475
3. Cunliffe WJ, Gollnick HPM (2004) Akne, Pathophysiologie, Klinik, Diagnose und Therapie. Dunitz, London
4. Cunliffe WJ, Holland DB, Clark SM, Stables GI (2000) Comedogenesis: some new aetiological, clinical and therapeutic strategies. Br J Dermatol 142:1084-1091
5. De Young LM, Young JM, Ballaron SJ et al. (1984) Intradermal injection of Propionibacterium acnes: a model of inflammation relevant to acne. J Invest Dermatol 83:394-398
6. Gollnick H, Cunliffe W, Berson D et al. (2003) Management of acne: a report from a Global Alliance to Improve Outcomes in Acne. J Am Acad Dermatol 49:S1-37
7. Graham GM, Farrar MD, Cruse-Sawyer JE et al. (2004) Proinflammatory cytokine production by human keratinocytes stimulated with Propionibacterium acnes and P. acnes GroEL. Br J Dermatol 150:421-428
8. Guy R, Kealey T (1998) Modelling the infundibulum in acne. Dermatology 196:32-37
9. Guy R, Ridden C, Kealey T (1996) The improved organ maintenance of the human sebaceous gland: modeling in vitro the effects of epidermal growth factor, androgens, estrogens, 13-cis retinoic acid, and phenol red. J Invest Dermatol 106:454-460
10. Ingham E, Eady EA, Goodwin CE et al. (1992) Pro-inflammatory levels of interleukin-1 alpha-like bioactivity are present in the majority of open comedones in acne vulgaris. J Invest Dermatol 98:895-901
11. Jappe U (2003) Pathological mechanisms of acne with special emphasis on Propionibacterium acnes and related therapy. Acta Derm Venereol 83:241-248
12. Jappe U, Ingham E, Henwood J, Holland KT (2002) Propionibacterium acnes and inflammation in acne; P. acnes has T-cell mitogenic activity. Br J Dermatol 146:202-209
13. Jeremy AH, Holland DB, Roberts SG et al. (2003) Inflammatory events are involved in acne lesion initiation. J Invest Dermatol 121:20-27
14. Kim J, Ochoa MT, Krutzik SR et al. (2002) Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses. J Immunol 169:1535-1541
15. Kirschbaum JO, Kligman AM (1963) The pathogenic role of corynebacterium acnes in acne vulgaris. Arch Dermatol 88:832-833
16. Knor T (2005) The pathogenesis of acne. Acta Dermatovenerol Croat 13:44-49
17. Leyden J, Bergfeld W, Drake L et al. (2004) A systemic type I 5 alpha-reductase inhibitor is ineffective in the treatment of acne vulgaris. J Am Acad Dermatol 50:443-447
18. Leyden JJ (1995) New understandings of the pathogenesis of acne. J Am Acad Dermatol 32:515-25
19. Leyden JJ, McGinley KJ, Mills OH, Kligman AM (1975) Age-related changes in the resident bacterial flora of the human face. J Invest Dermatol 65:379-381
20. Leyden JJ, McGinley KJ, Mills OH, Kligman AM (1975) Propionibacterium levels in patients with and without acne vulgaris. J Invest Dermatol 65:382-384
21. Lucky AW (1995) Hormonal correlates of acne and hirsutism. Am J Med 98:895-945
22. McInturff JE, Kim J (2005) The role of toll-like receptors in the pathophysiology of acne. Semin Cutan Med Surg 24:73-78
23. Mempel M, Voelcker V, Kollisch G et al. (2003) Toll-like receptor expression in human keratinocytes: nuclear factor kappaB controlled gene activation by Staphylococcus aureus is toll-like receptor 2 but not toll-like receptor 4 or platelet activating factor receptor dependent. J Invest Dermatol 121:1389-1396
24. Norris JF, Cunliffe WJ (1988) A histological and immunocytochemical study of early acne lesions. Br J Dermatol 118:651-659
25. Plewig G, Kligman AM (2000) Acne and Rosacea. 3rd ed. Springer, Berlin
26. Schaller M, Loewenstein M, Borelli C et al. (2005) Induction of a chemoattractive proinflammatory cytokine response after stimulation of keratinocytes with Propionibacterium acnes and coproporphyrin III. Br J Dermatol 153:66-71
27. Thiboutot D, Chen W (2003) Update and future of hormonal therapy in acne. Dermatology 206:57-67
28. Vowels BR, Yang S, Leyden JJ (1995) Induction of proinflammatory cytokines by a soluble factor of Propionibacterium acnes: implications for chronic inflammatory acne. Infect Immun 63:3158-3165
29. Webster GF (1998) Inflammatory acne represents hypersensitivity to Propionibacterium acnes. Dermatology 196:80-81
30. Webster GF, Kligman AM (1979) A method for the assay of inflammatory mediators in follicular casts. J Invest Dermatol 73:266-268
31. Webster GF, Leyden JJ, Norman ME, Nilsson UR (1978) Complement activation in acne vulgaris: in vitro studies with Propionibacterium acnes and Propionibacterium granulosum. Infect Immun 22:523-529
32. Zouboulis CC, Nestoris S, Adler YD, Orth M, Orfanos CE, Picardo M, Camera E, Cunliffe WJ (2003) A new concept for acne therapy: a pilot study with zileuton, an oral 5-lipoxygenase inhibitor. Arch Dermatol 139:668-670
33. Zouboulis Ch C, Saborowski A, Boschnakow A (2005) Zileuton, an oral 5-lipoxygenase inhibitor, directly reduces sebum production. Dermatology 210:36-38