Blood substitutes: How close to a solution?

Developments in Biologicals

Volumn 120, Issue , 2005, Pages 45-52

  Klein, H G ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD SUBSTITUTE; FLUOROCARBON; HEMOGLOBIN; OXYGEN;

ARTICLE; EMULSION; HUMAN; METABOLISM;

BLOOD SUBSTITUTES; EMULSIONS; FLUOROCARBONS; HEMOGLOBINS; HUMANS; OXYGEN;

EID: 27744525113     PISSN: 14246074     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper

References (22)

1. Clark LC, Gollan R: Survival of mammals breathing organic liquids equilibrated with oxygen at atmospheric pressure. Science 1966; 152: 1755-1756.
2. Geyer RP, Monroe RG, Taylor K: Survival of rats perfused with a perfluorocarbon-detergent preparation, in Norman JV, Folkman J, Hardison LE Ridolf LE, Veith FJ (eds): Organ Perfusion and Preparation, New York, Appleton-Crofts, 1968, pp 85-95.
3. Teicher BA, Schwartz GN, Sotomayor EA, Robinson MF, Dupuis MP, Menon K. Oxygenation of tumors by a hemoglobin solution. J Cancer Res Clin Oncol 1993; 120: 85-90.
4. Gould SA, Rosen AL, Sehgal LR et al: Fluosol-DA as a red cell substitute in acute anemia. N Engl J Med 1986; 314: 218-221.
5. Keipert PE: Perfluorochemical emulsions: future alternatives to transfusion, in Chang TMS (ed): Principles, Methods, Products and Clinical Trials, Zurich, Karger, 1998, pp 127-156.
6. Spahn Dr, van Brempt R, Theilmeier G et al: Perflubron emulsion delays blood transfusions in orthopedic surgery. European Perflubron Emulsion Study Group. Anesthesiology 1999; 91: 1195-1208.
7. Sakas DE, Whitaker KW, Crowell RM et al: Perfluorocarbons: recent developments and implications for neurosurgery, J Neurosurg 1996; 85: 248-254.
8. Premaratne S, Harada RN, Chun P et al: Effects of perfluorocarbon exchange transfusion on reducing myocardial infarct size in a primate model of ischemia-reperfusion injury: A prospective, randomized study, Surgery 1995; 1127:670-676.
9. Horn E-P, Standl T, Wilhelm S et al: Bovine hemoglobin increases skeletal muscle oxygenation during 95 % artificial arterial stenosis. Surgery 1997; 121: 411-418.
10. Teicher BA, Holden SA, Ara G et al: Restoration of tumor oxygenation after cytotoxic therapy by a perflubron emulsion/carbogen breathing. Cancer J 1995; 1:43-48.
11. Kaul DK, Liu X, Nagel RL: Ameliorating effects of fluorocarbon emulsion on sickle red blood cell-induced obstruction in an ex vivo vasaculature, Blood 2001; 98: 3128-3131.
12. Mullon J, Giacoppe G, Clagett C, McCune D, Dillard T: Polymerized bovine hemoglobin transfusions in a patient with severe autoimmune hemolytic anemia. New Engl J Med 2000; 342: 1638-1643.
13. Weiskopf RB, Viele MK, Feiner J et al: Human cardiovascular and metabolic response to acute isovolemic anemia. JAMA 1998; 279 (3): 217-221.
14. Brecher ME, Goodnough LT, Monk T: The value of oxygen-carrying solutions in the operative setting, as determined by mathematical modeling. Transfusion 1999; 39: 396-402.
15. Gould SA, Moore EE, Hoyt DB et al: The first randomized trial of human polymerized hemoglobin in acute trauma and emergent surgery. J Am Coll Surg 1998; 187: 113-122.
16. Fluid Resuscitation. State of the science for treating combat casualties and civilian injuries. Pope A, French G, Longnecker DE (eds): Washington, National Academy Press, 1999.
17. Busch MP: Closing the windows on viral transmission by blood transfusion, in Stramer SL (ed): Blood Safety in the New Millennium, Bethesda, American Association of Blood Banks, 2001, pp 33-54.
18. Safe blood starts with me. World Health Organization and International Federation of Red Cross and Red Crescent Societies. Geneva 2000:12.
19. Varmus H, Satcher D: Ethical complexities of conducting research in developing countries. N Engl J Med 1997; 337: 1003-1005.
20. Sloan EP, Koenigsberg M, Gens D et al: Diaspirin cross-linked hemoglobin (DCLHb) in the treatment of severe traumatic hemorrhagic shock. A randomized controlled efficacy trial. JAMA 1999; 282: 1857-1864.
21. Winslow RM, Gonzales A, Gonzales ML, et al: Vascular resistance and the efficacy of red cell substitutes in a rat hemorrhage model. J Appl Physiol 1998; 85 (3) 993-1003.
22. Winslow RM: Current status of blood substitute research: towards a new paradigm. J Intern Med 2003; 253: 508-517.