Ameliorating effects of fluorocarbon emulsion on sickle red blood cell-induced obstruction in an ex vivo vasculature

Blood

Volumn 98, Issue 10, 2001, Pages 3128-3131

  Kaul, Dhananjay K ^a   Liu, Xiao Du ^a   Nagel, Ronald L ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUOROCARBON; THROMBOCYTE ACTIVATING FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD FLOW; BLOOD OXYGENATION; BLOOD VESSEL OCCLUSION; CELL ADHESION; CONTROLLED STUDY; DRUG EFFECT; EMULSION; MICROSCOPY; MICROVASCULATURE; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RAT; SICKLE CELL ANEMIA; VASCULAR ENDOTHELIUM; VASCULAR RESISTANCE;

EID: 0035892111     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V98.10.3128     Document Type: Article

References (13)

1. Kaul DK, Fabry ME, Nagel RL. Erythrocytic and vascular factors influencing the microcirculatory behavior of blood in sickle cell anemia. Ann N Y Acad Sci. 1989;565:316-326.
2. Kaul DK, Fabry ME, Nagel RL. Microvascular sites and characteristics of sickle cell adhesion to vascular endothelium in shear flow conditions: pathophysiological implications. Proc Natl Acad Sci U S A. 1989;86:3356-3360.
3. Fabry ME, Rajanayagam V, Fine E, et al. Modeling sickle cell vaso-occlusion in the rat leg: quantification of trapped sickle cells and correlation with 31 P metabolic and 1H magnetic resonance imaging changes. Proc Natl Acad Sci U S A. 1989;86:3808-3812.
4. Kaul DK, Fabry ME, Costantini F, Rubin EM, Nagel RL. In vivo demonstration of red cell-endothelial interaction, sickling and altered microvascular response to oxygen in the sickle transgenic mouse. J Clin Invest. 1995;96:2845-2853.
5. Faithfull NS, Weers JG. Perfluorocarbon compounds. Vox Sang. 1998;74(suppl 2):243-248.
6. Flaim SF, Hazard DR, Hogan J, Peters RM. Characterlzation and mechanism of side-effects of Oxygent HT (highly concentrated fluorocarbon emulsion) in swine. Artif Cells Blood Substit Immobil Biotechnol. 1994;22:1511-1515.
7. Baez S, Lamport H, Baez A. Pressure effects in living microscopic vessels. In: Copley AL, Stainsby G, eds. Flow Properties of Blood and Other Biological Systems. London, United Kingdom: Pergamon Press; 1960:122-136.
8. Kaui DK, Fabry ME, Windisch P, Baez S, Nagel RL. Erythrocytes in sickle cell anemia are heterogeneous in their rheological and hemodynamic characteristics. J Clin Invest. 1983;72:22-31.
9. Kauf DK. Flow properties and endothelial adhesion of sickle erythrocytes in an ex vivo microvascular preparation. In: Ohnishi ST, Ohnishi T, eds. Membrane Abnormalities in Sickle Cell Disease and in Other Red Blood Cell Disorders. Boca Raton, FL: CRC Press; 1994:217-241.
10. Green HD, Rapela C, Conard MD. Resistance (conductance) and capacitance phenomena in terminal vascular beds. In: Hamilton WF, Dow P, eds. Handbook of Physiology. Vol 2. Washington, DC: American Physiological Society; 1963:122-136.
11. Kaul DK, Tsai HM, Liu XD, Nakada MT, Nagel RL, Coller BS. Monoclonal antibodies to αVβ3 (7E3 and LM609) inhibit sickle red blood cell-endothelium interactions induced by platelet-activating factor [see comments]. Blood. 2000;95:368-374.
12. Steinberg MH, Lu ZH, Barton FB, Terrin ML, Charache S, Dover GJ. Fetal hemoglobin in sickle cell anemia: determinants of response to hydroxyurea: multicenter study of hydroxyurea. Blood. 1997;89:1078-1088.
13. Smith CM, Hebbel RP, Tukey DP, Clawson CC, White JG, Vercellotti GM. Pluronic F-68 reduces the endothelial adherence and improves the rheology of liganded sickle erythrocytes. Blood. 1987;69:1631-1636.