Proliferative senescence in hematopoietic stem cells during ex-vivo expansion

Folia Histochemica et Cytobiologica

Volumn 43, Issue 4, 2005, Pages 197-202

  Piacibello, Wanda ^a   Gammaitoni, Loretta ^a   Pignochino, Ymera ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

Cell sensecence; Ex vivo expansion; Hematopoietic stem cells; NOD SCID mice; Telomere shortening; Transplantation

Indexed keywords

CD34 ANTIGEN; TELOMERASE;

CELL AGING; CELL DIFFERENTIATION; CELL ISOLATION; CELL PROLIFERATION; DEVELOPMENTAL STAGE; ENZYME ACTIVITY; EX VIVO STUDY; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC SYSTEM; HUMAN; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PREDICTION; REVIEW; STRESS; TELOMERE; UMBILICAL CORD BLOOD; UPREGULATION;

EID: 27744514481     PISSN: 02398508     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (30)

1. Bhatia M, Wang JCY, Kapp U, Bonnet D, Dick JE (1997) Purification of primitive human hematopoietic cells of repopulating immune-deficient mice. Proc Natl Acad Sci USA 94: 5320-5325
2. Cashman JD, Lapidot T, Wang JC, Doedens M, Shultz LD, Lansdorp P, Dick JE, Eaves CJ (1997) Kinetic evidence of the regeneration of multilineage hematopoiesis from primitive cells in normal human bone marrow transplanted into immunodeficient mice. Blood 89: 4307-4316
3. Cawthorn RM, Smith KR, O'Brien E, Sivatchenko A, Kerber RA (2003) Association between telomere length in blood and mortality in people aged 60 years or older. Lancet 361: 393-395
4. Conneally E, Cashman J, Petzer A, Eaves C (1997) Expansion in vitro of transplantable human cord blood stem cells demonstrated using a quantitative assay of their lympho-myeloid repopulating activity in non obese diabetic-scid/scid mice. Proc Natl Acad Sci USA 94: 9836-9841
5. Engelhardt M, Finke J (2001) Does telomere shortening count? Blood 98: 888-890
6. Engelhardt M, Kumar R, Albanell J, Pettengell R, Han W, Moore MAS (1997) Telomerase regulation, cell cycle, and telomere stability in primitive hematopoietic cells. Blood 90: 182-193
7. Engelhardt M, MacKenzie K, Drullinsky P, Silver RT, Moore MAS (2000) Telomerase activity and telomere length in acute and chronic leukemia, pre and post-ex vivo culture. Cancer Res 60: 610-617
8. Franco S, MacKenzie KL, Dias S, Alvarez S, Rafii S, Moore MAS (2001) Clonal variation in phenotype and lifespan of human embryonic fibroblasts (MRC-5) transduced with the catalytic component of telomerase (hTERT). Exp Cell Res 268: 14-25
9. Gammaitoni L, Weisel KC, Gunetti M, Wu KD, Bruno S, Pinelli S, Bonati A, Aglietta M, Moore MA, Piacibello W (2004) Elevated telomerase activity and minimal telomere loss in cord blood long-term cultures with extensive stem cell replication. Blood 103: 4440-4448
10. Granger MP, Wright WE, Shay JW (2002) Telomerase in cancer and aging. Crit Rev Oncol Hematol 41: 29-40
11. Grewal SS, Barker JN, Davies SM, Wagner JE (2003) Unrelated donor hematopoietic cell transplantation: marrow or umbilical cord blood? Blood 101: 4233-4244
12. Jaroscak J, Goltry K, Smith A, Waters-Pick B, Martin PL, Driscoll TA, Howrey R, Chao N, Douville J, Burhop S, Fu P, Kurtzberg J (2003) Augmentation of umbilical cord blood (UCB) transplantation with ex-vivo expanded UCB cells: results of a phase I trial using the Aastrom Replicell system. Blood 101: 5061-5067
13. Kondo M, Wagers AJ, Manz MG, Prohaska SS, Scherer DC, Beilhack GF, Shizuru JA, Weissman IL (2003) Biology of hematopoietic stem cells and progenitors: implications for clinical application. Annu Rev Immunol 21: 759-806
14. Larochelle A, Vormoor J, Lapidot T, Sher G, Furukawa T, Li Q, Shultz LD, Olivieri NF, Stamatoyannopoulos G, Dick JE (1995). Engraftment of immune-deficient mice with primitive hematopoietic cells from beta-thalassemia and sickle cell anemia patients: implications for evaluating human gene therapy protocols. Hum Mol Genet 4: 163-172
15. Laughlin MJ, Barker J, Bambach B, Koc ON, Rizzieri DA, Wagner JE, Gerson SL, Lazarus HM, Cairo M, Stevens CE, Rubinstein P, Kurtzberg J (2001) Hematopoietic engraftment and survival in adult recipients of umbilical-cord blood from unrelated donors. N Engl J Med 344: 1815-1822
16. Liu K, Hodes RJ, Weng N (2001) Telomerase activation in human T lymphocytes does not require increase in telomerase reverse transcriptase (hTERT) protein but is associated with hTERT phosphorylation and nuclear translocation. J Immunol 166: 4826-4830
17. MacKenzie KL, Franco S, May C, Sadelain M, Moore MAS (2000) Mass cultured human fibroblasts overexpressing hTERT encounter a growth crisis following an extended period of proliferation. Exp Cell Res 259: 336-350
18. Moore MAS (2000) Commentary: Umbilical cord blood: an expendable resource. J Clin Invest 105: 855-856
19. Moore MAS (2003) In vitro and in vivo hematopoiesis. In: Atlas of Blood Cells: Function and Pathology. Zucker-Franklin D, Greaves MF, Grossi CE, Marmont AM [Eds], Arti Grafiche Salea, Milan, pp 1-38
20. Notaro R, Cimmino A, Tabarini D, Rotoli B, Luzzatto L (1997) In vivo telomere dynamics of human hematopoietic stem cells. Proc Natl Acad Sci USA 94: 13782-13785
21. Piacibello W, Sanavio F, Garetto L, Severino A, Bergandi D, Ferrario J, Fagioli F, Berger M, Aglietta M (1997). Extensive amplification and self-renewal of human primitive hematopoietic stem cells from cord blood. Blood 89: 2644-2653
22. Piacibello W, Sanavio F, Garetto L, Severino A, Dane A, Gammaitoni L, Aglietta M (1998) Differential growth factor requirement of primitive cord blood hematopoietic stem cell for self-renewal and amplification vs proliferation and differentiation. Leukemia 12: 718-727
23. Pflumio F, Izac B, Katz A, Shultz LD, Vainchenker W, Coulombel L (1996) Phenotype and function of human hematopoietic cells engrafting immune-deficient CB 7-severe combined immunodeficiency mice and non obese diabetic-severe combined immunodeficiency mice after transplantation of human cord blood mononuclear cells. Blood 6: 1479-1485
24. Rubinstein P, Carrier C, Carpenter C, et al. (2000) Graft selection in unrelated placental/umbilical cord blood (PCB) transplantation: influence and weight of HLA match and cell dose on engraftment and survival. Blood 96: 588a
25. Rufer N, Brummendorf TH, Chapuis B, Helg C, Landsdrorp PM, Roosnek E (2001) Accelerated telomere shortening in hematological lineages is limited to the year following stem cell transplantation. Blood 97: 575-577
26. Rufer N, Brummendorf TH, Chapuis B, Helg C, Landsdorp PM, Roosnek E (2001). Consequence of stem cell transplantation-induced telomere shortening. Blood 98: 889
27. Vaziri H, Dragowska W, Allsopp RC, Thomas TE, Harley CB, Lansdorp PM (1994) Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age. Proc Natl Acad Sci USA 91: 9857-9860
28. Vormoor J, Lapidot T, Pflumio F, Risdon G, Patterson B, Broxmeyer HE, Dick JE (1994) Immature human cord blood progenitors engraft and proliferate to high levels in severe combined immunodeficient mice. Blood 83: 2489-2497
29. Wynn RF, Cross MA, Hatton C, Will AM, Lashford LS, Dexter TM, Testa NG (1998) Accelerated telomere shortening in young recipients of allogeneic bone-marrow transplants. Lancet 351: 178-181
30. Zimmermann S, Glaser S, Ketteler R, Waller CF, Klingmuller U, Martens UM (2004) Effects of telomerase modulation in human hematopoietic progenitor cells. Stem Cells 22: 741-749