Accelerated telomere shortening in hematological lineages is limited to the first year following stem cell transplantation

Blood

Volumn 97, Issue 2, 2001, Pages 575-577

  Rufer, Nathalie ^a   Brümmendorf, Tim H ^c   Chapuis, Bernard ^c   Helg, Claudine ^c   Lansdorp, Peter M ^b   Roosnek, Eddy ^c  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^b BRITISH COLUMBIA CANCER AGENCY   (Canada)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

TELOMERASE;

ARTICLE; CONTROLLED STUDY; FLOW CYTOMETRY; FLUORESCENCE IN SITU HYBRIDIZATION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL; LYMPHOCYTE DIFFERENTIATION; MEMORY CELL; MONOCYTE; PERIPHERAL BLOOD STEM CELL; PRIORITY JOURNAL; T LYMPHOCYTE; TELOMERE; TREATMENT OUTCOME;

EID: 0035863831     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V97.2.575     Document Type: Article

References (19)

1. A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes
2. Telomeres shorten during ageing of human fibroblasts
3. Evidence for a critical telomere length in senescent human fibroblasts
4. Changes of telomere length in children after hematopoietic stem cell transplantation
5. Accelerated telomere shortening in young recipients of allogeneic bone-marrow transplants
6. Telomere length changes in patients undergoing hematopoietic stem cell transplantation
7. Telomere shortening in leucocyte subsets of long-term survivors of allogeneic bone marrow transplantation
8. In vivo telomere dynamics of human hematopoietic stem cells
9. Shortening of telomeres in recipients of both autologous and allogeneic hematopoietic stem cell transplantation
10. Evidence for a mitotic clock in human hematopoietic stem cells: Loss of telomeric DNA with age
11. Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry
12. Terminology and nomenclature for standardization in quantitative fluorescence cytometry
13. Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood
14. Improving the outcome of bone marrow transplantation by using CD52 monoclonal antibodies to prevent graft-versus-host disease and graft rejection
15. Genetic determination of telomere size in humans: A twin study of three age groups
16. Peripheral T lymphocytes: Expansion potential and homeostatic regulation of pool sizes and CD4/CD8 ratios in vivo
17. Recovery of immune reactivity after T cell depleted bone marrow transplantation depends on thymic activity
18. Reconstitution of the T cell compartment after bone marrow transplantation: Restoration of the repertoire by thymic emigrants
19. Regulated expression of Telomerase activity in human T lymphocyte development and activation