Effects of dexmedetomidine on intracranial hemodynamics in severe head injured patients;Efectos de la dexmedetomidina sobre la hemodinámica intracraneal en pacientes con lesión encefálica traumatica grave

Neurocirugia

Volumn 16, Issue 5, 2005, Pages 411-417

  Grille, P ^a   Biestro, Alberto ^a   Farina G ^a   Miraballes, R ^a  

^a UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

Author keywords

Cerebral perfusion pressure; Dexmedetomidine; Head injury; Head trauma; Intracranial hemodynamics; Intracranial pressure; Oxygen jugular saturation

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; DEXMEDETOMIDINE; OXYGEN;

ADULT; ARTICLE; BRAIN PERFUSION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG SAFETY; FEMALE; GLASGOW COMA SCALE; GLOMUS JUGULARE; HEAD INJURY; HEMODYNAMICS; HUMAN; INTENSIVE CARE UNIT; INTRACRANIAL PRESSURE; MALE; MEAN ARTERIAL PRESSURE; OXYGEN SATURATION; PROSPECTIVE STUDY;

EID: 27744510968     PISSN: 11301473     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1130-1473(05)70388-2     Document Type: Article

References (30)

1. Bachand, R., Scholz, J., Finaud, M., et al.: The effects of dexmedetomidine in patientes in the intensive care setting. Intensive Care Med. 1999; 25 Suppl. 1: S 160.
2. Belleville, J.P., Ward, D.S., Bloor, B.C., et al.: Effects of intravenous dexmedetomidine in humans. I. Sedation, ventilation, and metabolic rate. Anesthesiology 1992; 77: 1125-1133.
3. Bhana, N., Goa, K., Mc Clellan, K.: Dexmedetomidine. Drugs. 2000; 59: 263-268.
4. Bloor, B.C., Ward, D.S., Belleville, J.P., et al.: Effects of intravenous dexmedetomidine in humans. II. Hemodynamic changes. Anesthesiology 1992; 77: 1134-1142.
5. Coursin, D.B., Coursin, D.B., Maccioli, G.A.: Dexmedetomidine. Curr Opin Crit Care. 2001; 7: 221-226.
6. Ely, E.W., Siegel, M.D., Inouye, S.K.: Delirium in the intensive care unit: An under-recognized syndrome of organ dysfunction. Seminars in Respiratory & Critical Care Medicine. 2001; 22: 115-126.
7. Engelhard, K., Werner, C., Kaspar, S., Mollenberg, O., Blobner, M., Bachl, M., Kochs, E.: Effect of the alpha2-agonist dexmedetomidine on cerebral neurotransmitter concentrations during cerebral ischemia in rats. Anesthesiology. 2002; 96: 450-457.
8. Engelhard, K., Werner, C., Eberspacher, E., Bachl, M., Hildt, E., et al. Blobner, M.: The effect of the alpha 2-agonist dexmedetomidine and the N-methyl-D-aspartate antagonist S(+)-ketamine on the expression of apoptosis-regulating proteins after incomplete cerebral ischemia and reperfusion in rats. Anesth Analg. 2003; 96: 524-531.
9. Ganjoo, P., Farber, N., Hudetz, A., Smith, J.J., Samso, E., Kampine, J. et al.: In Vivo Effects of Dexmedetomidine on Laser-Doppler Flow and Pial Arteriolar Diameter. Anesthesiology. 1998; 88: 429-439.
10. Iida, H., Iida, M., Ohata, H., Nagase, K., Dohi, S.: Hypothermia attenuates the vasodilator effects of Dexmetomidine on pial vessels in rabbits in vivo. Anesth Analg 2004; 98: 477-482.
11. Jolkkonen, J., Puurunen, K., Koistinaho, J., Kauppinen, R., Haapalinna, A., Nieminen, L., et al.: Neuroprotection by the alpha2-adrenoceptor agonist, dexmedetomidine, in rat focal cerebral ischemia. Eur J Pharmacol. 1999 7; 372: 31-36.
12. Jorden, V.S.B., Tung, A.: Dexmedetomidine: Clinical Update Anesth Periop Mesd and Pain 2002; 21: 265-274.
13. Kamibayashi, T., Maze, M.: Clinical uses of α2 adrenergic agonists. Anesthesiology 2000; 93: 1345-1349.
14. Katsanoulas, C.: Redefining intensive care unit sedation. Internacional Congress and Symposium Series - Redefining sedation. 1998; 221: 83-88.
15. Kelly, D.F., Goodale, D.B., Williams, J., Herr, D.L., Chappel, E.T., Rosner, M.J., et al.: Propofol in the treatment of moderate and severe head injury: a randomized, prospective double-blinded pilot trial. J Neurosurg. 1999; 90: 1042-1052.
16. Knaus, D.A., Draper, E.A., Wagner, D.P., Zimmerman, I.E. APACHE II: A severity of disease classification system. Crit Care Med. 1985; 13: 818-829
17. Kuhmonen, J., Pokorny, J., Miettinen, R., Haapalinna, A., Jolkkonen, J., Riekkinen, P. Sr et al.: Neuroprotective effects of Dexmedetomidine in the Gerbil hippocampus after transient global ischemia. Anesthesiology 1997; 87: 371-377.
18. Louvelle, J.M.: Sedation in the intensive care unit: an overview. Can J Hosp Pharm. 1995; 48: 344-347.
19. Maier, C., Steinberg, G.K., Sun, G.H., Zhi, G.T., Maze, M.: Neuroprotection by the alpha 2-adrenoreceptor agonist dexmedetomidine in a focal model of cerebral ischemia. Anesthesiology. 1993; 79: 306-312.
20. Marshall, L.F., Marshall, S.B., Klauber, M.R., van Berkum Clark, M.: A new classification of head injury based on computerized tomography. J Neurosurg 1991; 75 (Suppl): S14-S20.
21. Maset, A.L., Maramarou, A., Ward, J.D., Choi, S., Lutz, H.A., Brooks, D,: Pressure-volume index inhead injury patients. J Neurosurg 1987; 67: 832-840.
22. Pentittila, J., Helminen, A., Anttila, M., Hinkka, S., Scheinin, H.: Cardiovascular and parasympathetic effects of dexmedetomidina in healthy subjects. Can J Physiol Pharmacol 2004; 82: 359-362
23. Prielipp, R.C., Wall, M.H., Tobin, J.R., Groban, L., Cannon, M.A., Fahey, F.H., et al.: Dexmedetomidine-induced sedation in volunteers decreases regional and global cerebral blood flow. Anesth Analg. 2002; 95: 1052-1059.
24. Sahuquillo, J., Biestro, A., Mena, M.P., Amoros, S., Lung, M., Poca, M.A. et al.: First tier measures in the treatment of intracranial hypertension in the patient with severe craniocerebral trauma. Proposal and justification of a protocol. Neurocirugia. 2002; 13: 78-100.
25. Shapiro, B.A., Warren, J., Egol, A.B., et al.: Practice parameters for intravenous analgesia and sedation for adult patients in the intensive care unit: an executive summary. Crit Care Med. 1995; 23: 1596-600.
26. Shelly, M.P.: Dexmedetomidine: a real innovation or more of the same? Editorial Br J Anaesth 2001; 87: 677-678.
27. Talke, P., Tong, C., Lee, H.W., Caldwell, J., Eisenach, J.C., Richardson, C.A.: Effect of Dexmedetomidine on lumbar cerebrospinal fluid pressure in humans. Anesth Analg. 1997; 85: 358-364.
28. Venn, R.M., Newman, P.J., Grounds, R.M.: A phase II study to evaluate the efficacy of Dexmedetomidine for sedation in the medical intensive care unit. Int Care Med 2003; 29: 201-207.
29. Wheeler, A.P.: Sedation, analgesia and paralysis in the intensive care unit. Chest. 1993; 104: 566-577.
30. Wijeysundera, D.N., Naik, J.S., Scott Beattie, W.: Alpha-2 adrenergic agonist to prevent perioperative cardiovascular complications: A Meta-analysis. Am J Med 2003; 114: 742-752.