Concentrations of homocysteine, related metabolites and asymmetric dimethylarginine in preeclamptic women with poor nutritional status

Clinical Chemistry and Laboratory Medicine

Volumn 43, Issue 10, 2005, Pages 1139-1146

  Herrmann, Wolfgang ^a   Isber, Sonia ^a   Obeid, Rima ^a   Herrmann, Markus ^a   Jouma, Muhidien ^b  

^a SAARLAND UNIVERSITY   (Germany)

^b DAMASCUS UNIVERSITY   (Syrian Arab Republic)

Author keywords

Asymmetric dimethylarginine; Folate; Homocysteine; Preeclampsia

Indexed keywords

CYANOCOBALAMIN; CYSTATHIONINE; FOLIC ACID; HOMOCYSTEINE; METHYLMALONIC ACID; N(G),N(G) DIMETHYLARGININE; PYRIDOXINE; VITAMIN;

ADULT; AMINO ACID BLOOD LEVEL; ARTICLE; CONTROLLED STUDY; DEVELOPING COUNTRY; DIET SUPPLEMENTATION; ENDOTHELIUM; FEMALE; FOLIC ACID BLOOD LEVEL; GESTATIONAL AGE; HUMAN; MAJOR CLINICAL STUDY; NUTRITIONAL DISORDER; NUTRITIONAL STATUS; PREECLAMPSIA; PREGNANCY; PRIORITY JOURNAL; SOCIAL STATUS; STATISTICAL SIGNIFICANCE; VITAMIN BLOOD LEVEL; VITAMIN INTAKE;

ADULT; ARGININE; FEMALE; HOMOCYSTEINE; HUMANS; NUTRITIONAL STATUS; PRE-ECLAMPSIA; PREGNANCY; TIME FACTORS; VITAMINS;

EID: 27744496395     PISSN: 14346621     EISSN: 14346621     Source Type: Journal    
DOI: 10.1515/CCLM.2005.198     Document Type: Article

References (38)

1. MacKay AP, Berg CJ, Atrash HK. Pregnancy-related mortality from preeclampsia and eclampsia. Obstet Gynecol 2001;97:533-8.
2. Roberts JM, Cooper DW. Pathogenesis and genetics of pre-eclampsia. Lancet 2001;357:53-6.
3. Vollset SE, Refsurn H, Irgens LM, Emblem BM, Tverdal A, Gjessing HK, et al. Plasma total homocysteine, pregnancy complications, and adverse pregnancy outcomes: the Hordaland Homocysteine study. Am J Clin Nutr 2000;71:962-8.
4. Ray JG, Laskin CA. Folic acid and homocyst(e)ine metabolic defects and the risk of placental abruption, preeclampsia and spontaneous pregnancy loss: A systematic review. Placenta 1999;20:519-29.
5. Andersson A, Hultberg B, Brattstrom L, Isaksson A. Decreased serum homocysteine in pregnancy. Eur J Clin Chem Clin Biochem 1992;30:377-9.
6. Murphy MM, Scott JM, Arija V, Molloy AM, Fernandez-Ballart JD. Maternal homocysteine before conception and throughout pregnancy predicts fetal homocysteine and birth weight. Clin Chem 2004;50:1406-12.
7. Murphy MM, Scott JM, McPartlin JM, Fernandez-Ballart JD. The pregnancy-related decrease in fasting plasma homocysteine is not explained by folic acid supplementation, hemodilution, or a decrease in albumin in a longitudinal study. Am J Clin Nutr 2002;76:614-9.
8. Cikot RJ, Steegers-Theunissen RP, Thomas CM, de Boo TM, Merkus HM, Steegers EA. Longitudinal vitamin and homocysteine levels in normal pregnancy. Br J Nutr 2001;85:49-58.
9. Steegers-Theunissen RP, Boers GH, Blom HJ, Trijbels FJ, Eskes TK. Hyperhomocysteinaemia and recurrent spontaneous abortion or abruptio placentae. Lancet 1992; 339:1122-3.
10. Austin RC, Lentz SR, Werstuck GH. Role of hyperhomocysteinemia in endothelial dysfunction and atherothrombotic disease. Cell Death Differ 2004;1l(Suppl 1):S56-64.
11. Powers RW, Evans RW, Majors AK, Ojimba JI, Ness RB, Crombleholme WR, et al, Plasma homocysteine concentration is increased in preeclampsia and is associated with evidence of endothelial activation. Am J Obstet Gynecol 1998;179:1605-11,
12. Roberts JM, Taylor RN, Musci TJ, Rodgers GM, Hubel CA, McLaughlin MK. Preeclampsia: an endothelial cell disorder. Am J Obstet Gynecol 1989;161:1200-4.
13. Powers RW, Evans RW, Ness RB, Crombleholme WR, Roberts JIM. Homocysteine and cellular fibronectin are increased in preeclampsia, not transient hypertension of pregnancy. Hypertens Pregnancy 2001;20:69-77.
14. Sanchez SE, Zhang C, Rene Malinow M, Ware-Jauregui S, Larrabure G, Williams MA. Plasma folate, vitamin B(12), and homocyst(e)ine concentrations in preeclamptic and normotensive Peruvian women. Am J Epidemiol 2001;153:474-80.
15. Cotter AM, Molloy AM, Scott JM, Daly SF, Elevated plasma homocysteine in early pregnancy: a risk factor for the development of severe preeclampsia. Am J Obstet Gynecol 2001;185:781-5.
16. Savvidou MD, Hingorani AD, Tsikas D, Frolich JC, Vallance P, Nicolaides KH. Endothelial dysfunction and raised plasma concentrations of asymmetric dimethylarginine in pregnant women who subsequently develop pre-eclampsia. Lancet 2003;361:1511-7.
17. Stuhlinger MC, Oka RK, Graf EE, Schmolzer I, Upson BM, Kapoor O, et al. Endothelial dysfunction induced by hyperhomocyst(e)inemia: role of asymmetric dimethylarginine. Circulation 2003;108:933-8.
18. Minkauskiene M, Nadisauskiene R, Padaiga Z, Makari S. Systematic review on the incidence and prevalence of severe maternal morbidity. Medicina (Kaunas) 2004;40: 299-309.
19. Duley L. Maternal mortality associated with hypertensive disorders of pregnancy in Africa, Asia, Latin America and the Caribbean. Br J Obstet Gynaecol 1992;99: 547-53.
20. Bakour SH, Nassif B, Nwosu EC. Outcome of ruptured uterus at university teaching hospital Aleppo, Syria. J Obstet Gynecol 1998;15:424-8.
21. Herrmann W, Obeid R, Jouma M. Hyperhomocysteinemia and vitamin B-12 deficiency are more striking in Syrians than in: Germans - causes and implications. Atherosclerosis 2003;166:143-50.
22. Obeid R, Jouma M, Herrmann W. Cobalamin status (holo-transcobalamin, methylmalonic acid) and folate as determinants of homocysteine concentration. Clin Chem 2002;48:2064-5.
23. Schulze F, Wesemann R, Schwedhelm E, Sydow K, Albsmeier J, Cooke JP, et al. Determination of asymmetric dimethylarginine (ADMA) using a novel ELISA assay. Clin Chem Lab Med 2004;42:1377-83.
24. Ronnenberg AG, Goldman MB, Chen D, Aitken IW, Willett WC, Selhub J, Xu X. Preconception folate and vitamin B(6) status and clinical spontaneous abortion in Chinese women. Obstet Gynecol 2002;100:107-13.
25. Ronnenberg AG, Goldman MB, Chen D, Aitken IW, Willett WC, Selhlub J, Xu X. Preconception homocysteine and B vitamin status and birth outcomes in Chinese women. Am J Clin Nutr 2002;76:1385-91.
26. Adams MJ Jr, Khoury MJ, Scanlon KS, Stevenson RE, Knight GJ, Haddow JE, et al. Elevated midtrimester serum methylmalonic acid levels as a risk factor for neural tube defects. Teratology 1995;51:311-7.
27. Bjorke Monsen AL, Ueland PM, Vollset SE, Guttormsen AB, Markestad T, Solheim E, et al. Determinants of cobalamin status in newborns. Pediatrics 2001;108: 624-30.
28. McMullin MF, Young PB, Bailie KE, Savage GA, Lappin TR, White R. Homocysteine and methylmalonic acid as indicators of folate and vitamin B12 deficiency in pregnancy. Clin Lab Haematol 2001;23:161-5.
29. Bondevik GT,,Schneede J, Refsum H, Lie RT, Ulstein M, Kvale G. Homocysteine and methylmalonic acid levels in pregnant Nepali women. Should cobalamin supplementation be considered? Eur J Clin Nutr 2001;55:856-64.
30. Guerra-Shinohara EM, Morita OE, Peres S, Pagliusi RA, Sampaio Neto LF, D'Almeida V, et al. Low ratio of S-ade nosylmethionine to S-adenosylhomocysteine is associated with vitamin deficiency in Brazilian pregnant women and newborns. Am J Clin Nutr 2004;80:1312-21.
31. Maas R, Boger RH, Schwedhelm E, Casas JP, Lopez-Jaramillo P, Serrano N. Plasma concentrations of asymmetric dimethylarginine (ADMA) in Colombian women with pre-eclampsia. J Am Med Assoc 2004;291:823-4.
32. Sorensen TK,:Malinow MR, Williams MA, King IB, Luthy DA. Elevated second-trimester serum homocyst(e)ine levels and subsequent risk of preeclampsia. Gynecol Obstet Invest; 1999;48:98-103.
33. Herrmann W, Schorr H, Obeid R, Geisel J. Vitamin B-12 status, particularly holotranscobalamin II and methylmalonic acid concentrations, and hyperhomocysteinemia in vegetarians. Am J Clin Nutr 2003;78:131-6.
34. Tefferi A, Pruthi RK. The biochemical basis of cobalamin deficiency. Mayo Clin Proc 1994;69:181-6.
35. Laurence KM; James N, Miller M, Campbell H. Increased risk of recurrence of pregnancies complicated by fetal neural tube defects in mothers receiving poor diets, and possible benefit of dietary counselling. Br Med J 1980; 281: 1592-4.
36. Roberts JM, Balk JL, Bodnar LM, Belizan JM, Bergel E, Martinez A. Nutrient involvement in preeclampsia. J Nutr 2003;133(Suppl 2):1684S-92S.
37. Herrmann W, Hubner U, Koch I, Obeid R, Retzke U, Geisel J. Alteration of homocysteine catabolism in preeclampsia, HELLP syndrome and placental insufficiency. Clin Chem Lab Med 2004;42:1109-16.
38. Wannous S, Arous S. Incidence and determinants of low birth weight in Syrian government hospitals. East Mediterr Health J 2001;7:966-74.