Detection of initiating as well as promoting activity of chemicals by a novel cell transformation assay using v-Ha-ras-transfected BALB/c 3T3 cells (Bhas 42 cells)

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 588, Issue 1, 2005, Pages 7-21

  Asada, Shin ^a,b   Sasaki, Kiyoshi ^a   Tanaka, Noriho ^a,d   Takeda, Ken ^b   Hayashi, Makoto ^c   Umeda, Makoto ^a  

^a HATANO RESEARCH INSTITUTE   (Japan)

^b TOKYO UNIVERSITY OF SCIENCE   (Japan)

^c NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^d NONE   (Japan)

Author keywords

Bhas 42 cells; Complete carcinogen; Initiation and promotion; Transformation

Indexed keywords

1 NITROPYRENE; 3 METHYLCHOLANTHRENE; 7,12 DIMETHYLBENZ[A]ANTHRACENE; BENZ[A]ANTHRACENE; BENZO[A]PYRENE; BENZO[E]PYRENE; BENZO[GHI]PERYLENE; CHRYSENE; LITHOCHOLIC ACID; METHYLNITRONITROSOGUANIDINE; OKADAIC ACID; PERYLENE; PHORBOL 13 ACETATE 12 MYRISTATE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; PYRENE; TUMOR PROMOTER;

ANIMAL CELL; ARTICLE; BHAS 42 CELL; BIOASSAY; CARCINOGENESIS; CELL LINE; CELL STRAIN 3T3; CELL TRANSFORMATION; CLINICAL PROTOCOL; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; EMBRYO; GENETIC TRANSFECTION; MOUSE; NONHUMAN; PLATING MEDIUM; PRIORITY JOURNAL;

ANIMALS; BALB 3T3 CELLS; CARCINOGENICITY TESTS; CARCINOGENS; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; COCARCINOGENESIS; GENES, RAS; MICE; POLYCYCLIC COMPOUNDS; TRANSFECTION;

ANIMALIA;

EID: 27744493640     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2005.07.011     Document Type: Article

References (62)

1. I. Berenblum The cocarcinogenic action of croton resin Cancer Res. 1 1941 44 48
2. W.F. Friedwald, and P. Rous The initiating and promoting elements in tumor production J. Exp. Med. 80 1944 101 126
3. M. Hollstein, J. McCann, F.A. Angelosanto, and W.W. Nichols Short-term tests for carcinogens and mutagens Mutat. Res. 65 1979 133 226
4. J. Ashby, and R.W. Tennant Chemical structure, Salmonella mutagenicity and extent of carcinogenicity as indicators of genotoxic carcinogenesis among 222 chemicals tested in rodents by the U.S. NCI/NTP Mutat. Res. 204 1988 17 115
5. D.J. Fitzgerald, C. Piccoli, and H. Yamasaki Detection of non-genotoxic carcinogens in the BALB/c 3T3 cell transformation/mutation assay system Mutagenesis 4 1989 286 291
6. D.J. Fitzgerald, and H. Yamasaki Tumor promotion: models and assay systems Teratog. Carcinog. Mutagen. 10 1990 89 102
7. T. Kakunaga A quantitative system for assay of malignant transformation by chemical carcinogens using a clone derived from BALB-3T3 Int. J. Cancer 12 1973 463 473
8. T. Kakunaga, and J.D. Crow Cell variants showing differential susceptibility to ultraviolet light-induced transformation Science 209 1980 505 507
9. C.A. Reznikoff, D.W. Brankow, and C. Heidelberger Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of division Cancer Res. 33 1973 3231 3238
10. C.A. Reznikoff, J.S. Bertram, D.W. Brankow, and C. Heidelberger Quantitative and qualitative studies of chemical transformation of cloned C3H mouse embryo cells sensitive to postconfluence inhibition of cell division Cancer Res. 33 1973 3239 3249
11. A.L. Meyer In vitro transformation assays for chemical carcinogens Mutat. Res. 15 1983 323 338
12. J.C. Barrett, T.W. Hesterberg, and D.G. Thomassen Use of cell transformation systems for carcinogenicity testing and mechanistic studies of carcinogenesis Pharmacol. Rev. 36 2 Suppl 1984 53S 70S
13. S. Mondal, D.W. Brankow, and C. Heidelberger Two-stage chemical oncogenesis in cultures of C3H/10T1/2 cells Cancer Res. 36 1976 2254 2260
14. C. Boreiko, S. Mondal, K.S. Narayan, and C. Heidelberger Effect of 12-O-tetradecanoylphorbol-13-acetate on the morphology and growth of C3H/10T1/2 mouse embryo cells Cancer Res. 40 1980 4709 4716
15. IARC/NCI/EPA Working Group Cellular and molecular mechanisms of cell transformation and standardization of transformation assays of established cell lines for prediction of carcinogenic chemicals: Overview and recommended protocols Cancer Res. 45 1985 2395 2399
16. K. Ohmori, K. Sasaki, S. Asada, N. Tanaka, and M. Umeda An assay method for the prediction of tumor promoting potential of chemicals by the use of Bhas 42 cells Mutat. Res. 557 2004 191 202
17. K. Sasaki, H. Mizusawa, and M. Ishidate Isolation and characterization of ras-transfected BALB/3T3 clone showing morphological transformation by 12-O-tetradecanoyl-phorbol-13-acetate Jpn. J. Cancer Res. 79 1988 921 930
18. K. Sasaki, H. Mizusawa, M. Ishidate, and N. Tanaka Establishment of a highly reproducible transformation assay of a ras-transfected BALB 3T3 clone by treatment with promoters Basic Life Sci. 52 1990 411 416
19. T. Kakunaga The role of cell division in the malignant transformation of mouse cells treated with 3-methylcholanthrene Cancer Res. 35 1975 1637 1642
20. A. Fernandez, S. Mondal, and C. Heidelberger Probabilistic view of the transformation of cultured C3H/10T1/2 mouse embryo fibroblasts by 3-methylcholanthrene Proc. Natl. Acad. Sci. USA 77 1980 7272 7276
21. W.K. Lutz Dose-response relationships in chemical carcinogenesis: superposition of different mechanisms of action, resulting in linear-nonlinear curves, practical thresholds, J-shapes Mutat. Res. 405 1998 117 124
22. K. Saotome, H. Morita, and M. Umeda Cytotoxicity test with simplified crystal violet staining method using microtitre plates and its application to injection drug Toxic. In Vitro 3 1989 317 321
23. T. Tsuchiya, M. Umeda, H. Nishiyama, I. Yoshimura, S. Ajimi, M. Asakura, H. Baba, Y. Dewa, Y. Ebe, Y. Fushiwaki, S. Hamada, T. Hamamura, M. Hayashi, Y. Iwase, Y. Kajiwara, Y. Kasahara, M. Kawabata, E. Kitada, K. Kudo, K. Mashiko, D. Miura, F. Mizuhashi, F. Mizuno, M. Nakajima, Y. Nakamura, N. Nobe, T. Oishi, E. Ota, A. Sakai, M. Sato, S. Shimada, T. Sugiyama, C. Takahashi, Y. Takeda, N. Tanaka, C. Toyoizumi, T. Tsutsui, S. Wakuri, S. Yajima, and N. Yajima An interlaboratory validation study of the improved transformation assay employing BALB/c 3T3 cell: results of a collaborative study on the two-stage cell transformation assay by the non-genotoxic carcinogen study group ATRA 27 1999 685 702
24. 1: patterns of DNA adduct formation, removal, and excretion in relation to carcinogenesis Drug Metab. Rev. 13 1982 581 602
25. F.P. Guengerich, and T. Shimada Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes Chem. Res. Toxicol. 4 1991 391 407
26. S. Mondal, and C. Heidelberger Transformation of C3H/10T1/2CL8 mouse embryo fibroblasts by ultraviolet irradiation and a phorbol ester Nature 260 1976 710 711
27. C. Lasne, A. Gentil, and I. Chouroulinkov Two-stage carcinogenesis with rat embryo cells in tissue culture Br. J. Cancer 35 1977 722 729
28. L. Diamond, T. O'Brien, and G. Rovera Tumor promoters: effects on proliferation and differentiation of cells in culture Life Sci. 23 1978 1979 1988
29. N. Kaibara, E. Yurugi, and S. Koga Promoting effect of bile acids on the chemical transformation of C3H/10T1/2 fibroblasts in vitro Cancer Res. 44 1984 5482 5485
30. M. Suganuma, H. Fujiki, H. Suguri, S. Yoshizawa, M. Hirota, M. Nakayasu, M. Ojika, K. Wakamatsu, K. Yamada, and T. Sugimura Okadaic acid: an additional non-phorbol-12-tetradecanoate-13-acetate-type tumor promoter Proc. Natl. Acad. Sci. USA 85 1988 1768 1771
31. M. Umeda, K. Tanaka, and T. Ono Promotional effect of lithocholic acid and 3-hydroxyanthranilic acid on transformation of X-ray-initiated BALB/3T3 cells Carcinogenesis 10 1989 1665 1668
32. L.P. Yotti, C.C. Chang, and J.E. Trosko Elimination of metabolic cooperation in Chinese hamster cells by a tumor promoter Science 206 1979 1089 1091
33. A.W. Murray, and D.J. Fitzgerald Tumor promoters inhibit metabolic cooperation in cocultures of epidermal and 3T3 cells Biochem. Biophys. Res. Commun. 91 1979 395 401
34. M. Umeda, K. Noda, and T. Ono Inhibition of metabolic cooperation in Chinese hamster cells by various chemicals including tumor promoters Gann 71 1980 614 620
35. J.E. Trosko, and R.J. Ruch Cell-cell communication in carcinogenesis Frontiers Biosci. 3 1998 d208 d236
36. T. Tsuchiya, and M. Umeda Relationship between exposure to TPA and appearance of transformed cells in MNNG-initiated transformation of BALB/c 3T3 cells Int. J. Cancer 73 1997 271 276
37. T. Sugimura Multistep carcinogenesis: a 1992 perspective Science 258 1992 603 607
38. IARC, IARC Monographs on the evaluation of carcinogenic risks of chemicals to humans vol. 32, Polynuclear aromatic compounds, Part 1: Chemical, environmental and experimental data, IARC, Lyon, 1983.
39. IARC, IARC Monographs on the evaluation of carcinogenic risks to humans vol. 56: some naturally occurring substances: food items and constituents, heterocyclic aromatic amines and mycotoxins IARC, Lyon, 1993.
40. IARC, IARC Monographs on the evaluation of carcinogenic risks to humans vol. 82: some traditional herbal medicines, some mycotoxins, naphthalene and styrene, IARC, Lyon, 2002.
41. M. Sakai, D. Yoshida, and S. Mizusaki Mutagenicity of polycyclic aromatic hydrocarbons and quinones on Salmonella typhimurium TA97 Mutat. Res. 156 1985 61 67
42. J. McCann, E. Choi, E. Yamasaki, and B.N. Ames Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals Proc. Natl. Acad. Sci. USA 72 1975 5135 5139
43. K. Mossanda, F. Poncelet, A. Fouassin, and M. Mercier Detection of mutagenic polycyclic aromatic hydrocarbons in African smoked fish Food Cosmet. Toxicol. 17 1979 141 143
44. V.C. Dunkel, E. Zeiger, D. Brusick, E. McCoy, D. McGregor, K. Mortelmans, H.S. Rosenkranz, and V.F. Simmon Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol Environ. Mutagen. 6 Suppl. 2 1984 1 251
45. T.J. Oberly, M.A. Rexroat, B.J. Bewsey, K.K. Richardson, and K.C. Michaelis An evaluation of the CHO/HGPRT mutation assay involving suspension cultures and soft agar cloning: results for 33 chemicals Environ. Mol. Mutagen. 16 1990 260 271
46. IARC, IARC Monoraphs on the evaluation of carcinogenic risks of chemicals to humans suppl. 7, Overall evaluation of carcinogenicity: an updating of IARC Monographs from vol. 1 to vol. 42, IARC, Lyon, 1987.
47. E. Zeiger, B. Anderson, S. Haworth, T. Lawlor, and K. Mortelmans Salmonella mutagenicity tests: IV. Results from the testing of 300 chemicals Environ. Mol. Mutagen. 11 Suppl 12 1988 1 157
48. M. Diehl, and F. Fort Spiral Salmonella assay: validation against the standard pour-plate assay Environ. Mol. Mutagen. 27 1996 227 236
49. K. el-Bayoumy, and S.S. Hecht Mutagenicity of K-region derivatives of 1-nitropyrene; remarkable activity of 1- and 3-nitro-5H-phenanthro[4,5-bcd] pyran-5-one Mutat. Res. 170 1986 31 40
50. R.E. McMahon, J.C. Cline, and C.Z. Thompson Assay of 855 test chemicals in ten tester strains using a new modification of the Ames test for bacterial mutagens Cancer Res. 39 1979 682 693
51. R. Pahlman Mutagenicity of naphthacene, a non-bay-region aromatic hydrocarbon, in Salmonella Mutat. Res. 207 1988 205 212
52. M.R. O'Donovan The comparative responses of Salmonella typhimurium TA1537 and TA97a to a range of reference mutagens and novel compounds Mutagenesis 5 1990 267 274
53. F. Oesch, P. Bentley, and H.R. Glatt Prevention of benzo[a]pyrene-induced mutagenicity by homogeneous epoxide hydratase Int. J. Cancer 18 1976 448 452
54. S. Aonuma, T. Ushijima, M. Nakayasu, H. Shima, T. Sugimura, and M. Nagao Mutation induction by okadaic acid, a protein phosphatase inhibitor, in CHL cells, but not in S. typhimurium Mutat. Res. 250 1991 375 381
55. M.O. Bradley, B. Bhuyan, M.C. Francis, R. Langenbach, A. Peterson, and E. Huberman Mutagenesis by chemical agents in V79 Chinese hamster cells: a review and analysis of the literature. A report of the Gene-Tox Program Mutat. Res. 87 1981 81 142
56. C.G. Rogers, C. Heroux-Metcalf, and I. Langlois Evaluation of cytotoxicity and genotoxicity of okadaic acid, a non-phorbol ester type tumor promoter, in V79 Chinese hamster lung cells Toxicol. In Vitro 8 1994 269 276
57. B.S. Hass, R.H. Heflich, H.M. Schol, M.W. Chou, P.P. Fu, and D.A. Casciano Mutagenicity of the mononitrobenzo[a]pyrenes in Chinese hamster ovary cells mediated by rat hepatocytes or liver S9 Carcinogenesis 7 1986 681 684
58. E.K. Fifer, R.H. Heflich, Z. Djuric, P.C. Howard, and F.A. Beland Synthesis and mutagenicity of 1-nitro-6-nitrosopyrene and 1-nitro-8- nitrosopyrene, potential intermediates in the metabolic activation of 1,6- and 1,8-dinitropyrene Carcinogenesis 7 1986 65 70
59. K.B. Delclos, and R.H. Heflich Mutation induction and DNA adduct formation in Chinese hamster ovary cells treated with 6-nitrochrysene, 6-aminochrysene and their metabolites Mutat. Res. 279 1992 153 164
60. A.D. Mitchell, C.J. Rudd, and W.J. Caspary Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: intralaboratory results for sixty-three coded chemicals tested at SRI International Environ. Mol. Mutagen. 12 Suppl. 13 1988 37 101
61. D. Clive, R. McCuen, J.F. Spector, C. Piper, and K.H. Mavournin Specific gene mutations in L5178Y cells in culture Mutat. Res. 115 1983 225 251
62. A. Sakai, Y. Iwase, Y. Nakamura, K. Sasaki, N. Tanaka, and M. Umeda Use of a cell transformation assay with established cell lines, and a metabolic cooperation assay with V79 cells for the detection of tumor promoters: a review ATLA 30 2002 33 59