Use of a cell transformation assay with established cell lines, and a metabolic cooperation assay with V79 cells for the detection of tumour promoters: A review

ATLA Alternatives to Laboratory Animals

Volumn 30, Issue 1, 2002, Pages 33-59

  Sakai, Ayako ^a   Iwase, Yumiko ^a   Nakamura, Yoshiyuki ^a   Sasaki, Kiyoshi ^a   Tanaka, Noriho ^a   Umeda, Makoto ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

Established cell lines; Metabolic cooperation assay; Transformation assays; Tumour promoters; V79 cells

Indexed keywords

1,2 DIBROMOETHANE; 4 O METHYLPHORBOL 13 ACETATE 12 MYRISTATE; APLYSIATOXIN; ASBESTOS; BETA CAROTENE; BUTYLCRESOL; CAFFEINE; CALCITRIOL; CHENODEOXYCHOLIC ACID; CHLORPHENOTANE; CHOLIC ACID; DEBROMOAPLYSIATOXIN; DEOXYCHOLIC ACID; DEXAMETHASONE; DIETHYLSTILBESTROL; DINOPHYSISTOXIN 1; DITHRANOL; EPIDERMAL GROWTH FACTOR; ESTRADIOL; FIBROBLAST GROWTH FACTOR; FORMALDEHYDE; GLYCEROL 2 ACETATE 1 OLEATE; GLYCEROL DIOLEATE; HYDROCORTISONE; INSULIN; LITHOCHOLIC ACID; MEZEREIN; OKADAIC ACID; TUMOR PROMOTER; UNINDEXED DRUG;

ANIMAL CELL; CANCER PREVENTION; CARCINOGENICITY; CELL LINE; CELL TRANSFORMATION; CELL TYPE; CHEMICAL ANALYSIS; CONTROLLED STUDY; GENOTOXICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SAFETY;

ANIMALIA;

EID: 0036177896     PISSN: 02611929     EISSN: None     Source Type: Journal    
DOI: 10.1177/026119290203000105     Document Type: Review

References (172)

1. The mechanism of carcinogenesis: A study of the significance of cocarcinogenic action and related phenomena
2. Transformation of C3H/10T1/2Cl8 mouse embryo fibroblasts by ultraviolet irradiation and a phorbol ester
3. Two-stage chemical oncogenesis in cultures of C3H/10T1/2 cells
4. Elimination of metabolic cooperation in Chinese hamster cells by a tumor promoter
5. Tumor promoters inhibit metabolic cooperation in co-cultures of epidermal and 3T3 cells
6. Inhibition of cell-cell communication between Balb/c 3T3 cells by tumor promoters and protection by cAMP
7. Tumor promoters inhibit spontaneous and induced differentiation of murine erythroleukemia cells in culture
8. Tumor promoters inhibit spontaneous differentiation of Friend erythroleukemia cells in culture
9. Induction of differentiation in human promyelocytic leukemia cells by tumor promoters
10. Human promyelocytic leukemia cells in culture differentiate into macrophage-like cells when treated with a phorbol diester
11. A short-term in vitro assay for promoter substances using human lymphoblastoid cells latently infected with Epstein-Barr virus
12. Combined effect of the extracts from Croton niglium, Euphorbia lathyris or Euphorbia tirucalli and n-butyrate on Epstein-Barr virus expression on human lymphoblastoid P3HR-1 and Raji cells
13. Induction of the polyamine-biosynthetic enzymes in mouse epidermis by tumor promoting agents
14. Cellular and molecular mechanisms of cell transformation and standardization of transformation assays of established cell lines for the prediction of carcinogenic chemicals: Overview and recommended protocols
15. Correlation of anchorage-independent growth with tumorigenicity of chemically transformed mouse epidermal cells
16. In vitro assays that may be predictive of tumour-promoting agents
17. Isolation and characterization of ras-transfected BALB/3T3 clone showing morphological transformation by 12-O-tetradecanoylphorbol-13-acetate
18. Transformation of ras transfected BALB/3T3 clone (Bhas 42) by promoters: Application for screening and specificity of promoters
19. Morphological transformation of early passage golden Syrian hamster cells derived from cryo-preserved primary cultures as a reliable in vitro bioassay for identifying diverse carcinogens
20. Comparison of the standard and reduced pH Syrian hamster embryo (SHE) cell in vitro transformation assays in predicting the carcinogenic potential of chemicals
21. Development of 3T3-like lines from Balb/c mouse embryo cultures. Transformation susceptibility to SV-40
22. A quantitative system for assay of malignant transformation by chemical carcinogens using a clone derived from BALB/3T3
23. Cell variants showing differential susceptibility to ultraviolet light-induced transformation
24. Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of division
25. Quantitative and qualitative studies of chemical transformation of cloned C3H mouse embryo cells sensitive to post-confluence inhibition of cell division
26. Tumour promoter induces anchorage independence irreversibly
27. Cell transformation assays as predictors of human carcinogenicity. The report and recommendations of ECVAM workshop 39
28. Improvement of carcinogen identification in BALB/3T3 cell transformation by application of a 2-stage method
29. Tumor necrosis factor acts as a tumor promoter in BALB/3T3 cell transformation
30. Promotional effect of lithocholic acid and 3-hydroxyanthranilic acid on transformation of x-ray-initiated BALB/3T3 cells
31. Bromine residue at hydrophilic region influences biological activity of aplysiatoxin, a tumor promoter
32. Asbestos promotes morphological transformation and elevates expression of a gene family invariably induced by tumor promoters in C3H/10T1/2 cells
33. Promoting activity of 3-tert-butyl-4-hydroxyanisole (BHA) in BALB/3T3 cell transformation
34. Butylated hydroxytoluene: Tumour-promoting activity in an in vitro two-stage carcinogenesis assay
35. Dissociated occurrence of single-gene mutation and oncogenic transformation in C3H/10T1/2 cells exposed to ultraviolet light and caffeine
36. β-carotene as enhancer of cell transforming activity of powerful carcinogens and cigarette-smoke condensate on Balb/c 3T3 cells in vitro
37. Chemical cocarcinogenesis with the use of a subclone derived from BALB/3T3 cells with catechol as cocarcinogen
38. Promoting effect of bile acids on the chemical transformation of C3H/10T1/2 fibroblasts in vitro
39. Effects of dexamethasone and cortisone with x-ray irradiation on transformation of C3H/10T1/2 cells
40. Enhancement of Balb/c 3T3 cells transformation by 1,2-dibromoethane promoting effect
41. Promotion of C3H/10T1/2 morphological transformation by polychlorinated dibenzo-p-dioxin isomers
42. Effect of diethylstilbestrol on the transformable mouse embryo fibroblast C3H/10T1/2Cl8 cells. Tumor promotion, cell growth, DNA synthesis, and ornithine decarboxylase
43. A new tumor-promoting agent, dihydroteleocidin B, markedly enhances chemically induced malignant cell transformation
44. 3 markedly enhances chemically-induced transformation in BALB/3T3 cells
45. 3 of chemically induced transformation of BALB/3T3 cells without induction of ornithine decarboxylase or activation of protein kinase C
46. Promotion of BALB/3T3 cell transformation by the okadaic acid class of tumor promoters, okadaic acid and dinophysistoxin-1
47. Effects of activators and inhibitors of protein kinase C on two-stage transformation in BALB/3T3 cells
48. Epidermal growth factor, like tumor promoters, enhances viral and radiation-induced cell transformation
49. Effect of Clostridium perfringens-derived wound healing substance as compared with epidermal growth factor on the growth and morphological transformation of BALB/3T3 A31-1-1 cells
50. Transforming growth factor as a potent promoter in two-stage Balb/c 3T3 cell transformation
51. Weak promotion of C3H/10T1/2 cell transformation by repeated treatments with formaldehyde
52. Effect of insulin on the transformation of BALB/3T3 cells by x-ray irradiation
53. Cocarcinogenic activity of bile acids in the chemical transformation of C3H/10T1/2 fibroblasts in vitro
54. Effect of mouse skin tumor promoters upon [3H]uridine exchange and focus formation in cultures of C3H/10T1/2 mouse fibroblasts
55. Promotional effect of N-nitroso-N-(3-keto-1,2-butanediol)-3′-nitrotyramine (a nitrosated Maillard reaction product) in mouse fibroblast cells
56. Effects of 17β-estradiol on radiation transformation in vitro: Inhibition of effects by protease inhibitors
57. Okadaic acid and phorbol esters: Comparative effects of these tumor promoters on cell transformation, intercellular communication and differentiation in vitro
58. Enhancement of transformation and continuous inhibition of intercellular communication by 1-oleoyl-2-acetyl glycerol in Balb/c 3T3 cells
59. Orthovanadate, an inhibitor of protein tyrosine phosphatases, acts more potently as a promoter than as an initiator in the BALB/3T3 cell transformation
60. Induction by growth factors from platelets of the focus-forming transformed phenotype in carcinogen-treated C3H/10T1/2 fibroblasts
61. Phorbol ester-mediated inhibition of intercellular communication in Balb/c 3T3 cells: Relationship to enhancement of cell transformation
62. Enhancement of oncogenesis in C3H/10T1/2 mouse embryo cell cultures by saccharin
63. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) promotes the transformation of C3H/10T1/2 cells
64. Highly purified human-thrombin promotes morphological transformation of Balb/c 3T3 cells
65. Enhanced sensitivity of the C3H/10T1/2 cell transformation system to alkylating and chemotherapeutic agents by treatment with 12-O-tetradecanoylphorbol-13-acetate
66. Biological and biochemical characterization of cell lines derived from initiation-promotion transformed C3H/10T1/2 cells
67. Improvement in the efficiency of the in vitro transformation assay method using BALB/3T3 A31-1-1 cells
68. Relationship between exposure to TPA and appearance of transformed cells in MNNG-initiated transformation of Balb/c 3T3 cells
69. Thyroid hormone modulation of x-ray-induced in vitro neoplastic transformation
70. Tri-n-butyltin chloride promotes morphological transformation and induces proliferin expression in C3H10T1/2 cells
71. Active oxygen acts as a promoter of transformation in mouse embryo C3H/10T1/2/C18 fibroblasts
72. Genes and signal transduction in tumor promotion: Conclusions from studies with promoter resistant variants of JB-6 mouse epidermal cells
73. Benzoyl peroxide promotion of transformation of JB6 mouse epidermal cells: Inhibition by ganglioside GT but not retinoic acid
74. Induction of anchorage-independent growth of mouse JB6 cells by cholera toxin
75. Tumor-promoting effects of di(2-ethylhexyl)phthalate in JB6 mouse epidermal cells and mouse skin
76. Comparison of mouse pro-1 and pro-2 transfectants for response to tumor promoters and antipromoters
77. 3
78. Possible involvement of a lanthanide-sensitive protein kinase C substrate in lanthanide promotion of neoplastic transformation
79. Effects of transforming growth factor-β on the anchorage-independent growth of murine epithelial JB6 cells
80. Early superoxide dismutase-sensitive event promotes neoplastic transformation in mouse epidermal JB6 cells
81. Effects of various chemicals including tumor promoters on metabolic cooperation
82. Inhibition of metabolic cooperation in Chinese hamster V79 cells by various organic solvents and simple compounds
83. Studies on the mechanism of acetamide hepatocarcinogenicity
84. Evaluation of the V79 cell metabolic co-operation assay as a screen in vitro for developmental toxicants
85. Effects of selected anti-tumor-promoting chemicals on metabolic cooperation between Chinese hamster V79 cells
86. Applications of the Chinese hamster V79 metabolic cooperation assay in toxicology
87. Tests with the Chinese hamster V79 inhibition of metabolic cooperation assay
88. Assays for inhibition of metabolic cooperation by a microassay method
89. Inhibition of metabolic cooperation in Chinese hamster cells by various chemicals including tumor promoters
90. Effect of biological toxins on gap-junctional intercellular communication in Chinese hamster V79 cells
91. Inhibition of metabolic cooperation in Chinese hamster cells by organochlorine pesticides
92. Further characterization of the in vitro assay for inhibitors of metabolic cooperation in the Chinese hamster V79 cell line
93. Interactive effects of aldrin, cyclohexylamine, 2,4-diaminotoluene and two phorbol esters on metabolic cooperation between V79 cells
94. Effects of purified altertoxins I, II, and III in the metabolic communication V79 system
95. The effect of benzene and its derivatives on metabolic cooperation
96. Interlaboratory studies with the Chinese hamster V79 cell metabolic cooperation assay to detect tumor-promoting agents
97. Effect of mineral dusts on metabolic cooperation between Chinese hamster V79 cells in vitro
98. Elimination of metabolic cooperation is associated with the tumor promoters, oleic acid and anthralin
99. Elimination of metabolic cooperation and the induction of sister chromatid exchanges are not properties common to all promoting or co-carcinogenic agents
100. Effects of agents known to antagonize the enhancement of in vitro transformation by 12-tetradecanoyl-phorbol-13-acetate (TPA) on the TPA suppression of metabolic cooperation
101. The effect of anti-promoters and calcium antagonists on V79 Chinese hamster lung fibroblasts exposed to phorbol myristate acetate
102. Promotion of 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis by high dietary fat in the rat: Possible role of intercellular communication
103. Influence of lipids on gap-junction-mediated intercellular communication between Chinese hamster cells in vitro
104. Inhibition of metabolic coupling by metals
105. Inhibition of metabolic cooperation between Chinese hamster V79 cells by structurally diverse teratogens
106. Inhibition of intercellular communication in Chinese hamster V79 cells by fractionated asphalt fume condensates
107. Inhibition of metabolic cooperation between mammalian cells in culture by tumor promoters
108. Assays for inhibition of metabolic cooperation between mammalian cells in culture
109. Inhibition of metabolic cooperation between Chinese hamster V79 cells by tumor promoters and other chemicals
110. Effects of phorbol myristate acetate, phorbol dibutyrate, ethanol, dimethylsulfoxide, phenol, and seven metabolites of phenol on metabolic cooperation between Chinese hamster V79 lung fibroblasts
111. Inhibition of cell-cell communication by tumour promoters
112. Studies on the tumor-promoting activity of additives in biomaterials: Inhibition of metabolic cooperation by phenolic antioxidants involved in rubber materials
113. Effects of tetradecanoyl phorbol acetate, pyrethroids and DDT in the V79
114. Evaluation of the genetic and embryotoxic effects of bis(tri-n-butyltin)oxide (TBTO), a broad-spectrum pesticide, in multiple in vivo and in vitro short-term tests
115. Studies on the tumor-promoting activities of additives in biomaterials: Inhibition of metabolic cooperation by additives such as pigments and phenolic antioxidants
116. Inhibition of metabolic cooperation in Chinese hamster lung fibroblast cells (V79) in culture by various DDT-analogs
117. Studies on the tumor-promoting activity of polyurethanes: Depletion of inhibitory action of metabolic cooperation on the surface of a polyalkyleneurethane but not a polyetherurethane
118. Inhibition of intercellular gap junctional communication by alkyl ethers and its modulation by cAMP
119. Calmodulin involvement in TPA and DDT induced inhibition of intercellular communication
120. Effects of various chemicals including bile acids and chemical carcinogens on the inhibition of metabolic cooperation
121. in vitro testing and the carcinogenic potential of several nitrosated indole compounds
122. Chlorobenzilate-induced effects on enzyme-altered foci in rat liver and intercellular communication in rat liver WB-F344 epithelial cells
123. Inhibition of metabolic cooperation in vitro and enhancement of enzyme altered foci incidence in rat liver by the pyrethroid insecticide fenvalerate
124. Effect of cholesterol epoxides on the inhibition of intercellular communication and on mutation induction in Chinese hamster V79 cells
125. An evaluation of the effects of culture medium osmolality and pH on metabolic cooperation between Chinese hamster V79 cells
126. Inhibition of metabolic cooperation by cigarette smoke condensate and its fractions in V79 Chinese hamster lung fibroblasts
127. Effects of peroxisome proliferators and 12-O-tetradecanoyl phorbol-13-acetate on intercellular communication and connexin 43 in two hamster fibroblast systems
128. The potential role of bioactivation in tumor promotion: Indirect evidence from effects of phenol, sodium cyclamate and their metabolites on metabokic cooperation in vitro
129. Biological activity of a fluorescent 12-O-tetradecanoyl-phorbol-13-acetate derivative
130. Interaction between quercetin, TPA and DDT in the V79 metabolic cooperation assay
131. The activity of diazepam in a Chinese hamster V79 lung cell assay for tumor promoters
132. Inhibition of intercellular communication in cultures of Chinese hamster V79 cells by 2,4-dichlorophenoxyacetic acid and 2,4,5-trichlorophenoxyacetic acid
133. Synergistic inhibition of metabolic cooperation by oleic acid or 12-O-tetradecanoylphorbol-13-acetate and dichlorodiphenyltrichloroethane (DDT) in Chinese hamster V79 cells: Implication of a role for protein kinase C in the regulation of gap junctional intercellular communication
134. Inability of diethylstilbestrol to induce 6-thioguanine-resistant mutants and to inhibit metabolic cooperation of V79 Chinese hamster cells
135. 3
136. Limiting factors of the V79 cell metabolic cooperation assay for tumor promoters
137. Evaluation of the carcinogenic potential of 2,4-dinitrofluorobenzene and its implications regarding mutagenicity testing
138. Inhibition of metabolic cooperation by the anticonvulsants, diphenylhydantoin and phenobarbital
139. Tumor promoter-like activity of the molluscicidal latex of "Crown-of-Thorns" (Euphorbia milii var. hislopii) in the V79 metabolic cooperation assay
140. Tumour promotion related effects by the cyclodiene insecticide endosulfan studied in vitro and in vivo
141. Interruption of cell-cell communication in Chinese hamster V79 cells by various alkyl glycol ethers: Implications for teratogenicity
142. Genotoxic and/or epigenetic effects of some glycol ethers: Results of different short-term tests
143. Mutagenic effects of ferric nitrilotriacetate (Fe-NTA) on V79 Chinese hamster cells and its inhibitory effects on cell-cell communication
144. DNA-damaging, mutagenic, clastogenic and cell-cell communication inhibitory properties of gamma-oryzanol
145. Lack of tumor-promoting effects of flavonoids: Studies on rat liver preneoplastic foci and on in vivo and in vitro gap junctional intercellular communication
146. Elimination of metabolic cooperation by glycyrrhetinic acid, an anti-tumor promoter, in cultured Chinese hamster cells
147. The modulation of gap junctional communication by gossypol in various mammalian cell lines in vitro
148. Comparative metabolism and genotoxicity of the structurally similar nitrophenylenediamine dyes, HC Blue 1 and HC Blue 2, in mouse hepatocytes
149. Effects of gap-junctional intercellular communication by essential amino acid
150. Inhibition of intercellular communication in Chinese hamster V79 cells by Teleocidin
151. Inhibition of intercellular communication by chlordecone (kepone) and mirex in Chinese hamster V79 cells in vitro
152. Assessment of the carcinogenic potential of a proposed food coloring additive, laccaic acid, using short-term assays
153. Nongenotoxic mechanism in carcinogenesis: Role of inhibited intercellular communication
154. Studies on the tumor-promoting activities of polyethylene: Inhibitory activity of metabolic cooperation of polyethylene films containing an antioxidants
155. 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) induces gene mutations and inhibits metabolic cooperation in cultured Chinese hamster cells
156. Inhibition of gap-junctional intercellular communication between Chinese hamster lung fibroblasts by di(2-ethylhexyl)phthalate (DEHP) and trisodium nitrilotriacetate monohydrate (NTA)
157. Inhibition of biological actions of 12-O-tetradecanoylphorbol-13-acetate by inhibitors of protein kinase C
158. PBB inhibits metabolic cooperation in Chinese hamster cells in vitro: Its potential as a tumor promoter
159. Inhibition of metabolic cooperation in Chinese hamster V79 cells in culture by various polybrominated biphenyl (PBB) congeners
160. Role of cytoplasmic membrane in the screening of potential tumor promoters
161. Effects of 6-thioguanine on communication competence and factors affecting reversibility of phorbol ester inhibition in V79 cells measured by the metabolic cooperation assay and by dye coupling
162. Studies on tumor-promoting activity of polyethylene: Inhibitory activity of metabolic cooperation of polyethylene surfaces is markedly decreased by surface modification with collagen but not with RGDS peptide
163. A new hypothesis of tumorigenesis induced by biomaterials: Inhibitory potentials of intercellular communication play an important role on the tumour-promotion stage
164. Studies on the tumor-promoting activity of biomaterials: Inhibition of metabolic cooperation by polyetherurethane and silicone
165. Retinoic acid inhibits junctional communication between animal cells
166. Studies on the modulating effects of retinoic acid and retinol acetate using dye transfer and metabolic cooperation assays
167. Concentration-dependent differential effect of retinoic acid on intercellular metabolic cooperation
168. Saccharin may act as a tumour promoter by inhibiting metabolic cooperation between cells
169. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) does not inhibit intercellular communication in Chinese hamster V79 cells
170. Study of the biological effects of theophylline on V79 cells: Viability, membrane permeability, and metabolic cooperation
171. Inhibition of gap junctional-mediated intercellular communication in vitro by aldrin, dieldrin, and toxaphene: A possible cellular mechanism for their tumor-promoting and neurotoxic effects
172. Effects of fatty acids on gap junctional communication: Possible role in tumor promotion by dietary fat