Isotretinoin therapy induces DNA oxidative damage

Clinical Chemistry and Laboratory Medicine

Volumn 43, Issue 11, 2005, Pages 1178-1182

  Georgala, Sophia ^a   Papassotiriou, Ioannis ^b   Georgala, Catherina ^a   Demetriou, Elisabeth ^b   Schulpis, Kleopatra H ^b  

^a A Syngros Hospital   (Greece)

^b AGHIA SOPHIA CHILDREN S HOSPITAL   (Greece)

Author keywords

8 hydroxy 2 desoxyguanosine (8 OhdG); Cystic acne; DNA damage; Free radicals; Isotretinoin

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; CREATINE KINASE; ISOTRETINOIN; LIVER ENZYME; MUSCLE ENZYME;

ABNORMAL SUBSTRATE CONCENTRATION IN BLOOD; ACNE CYSTICA; ADOLESCENT; ADULT; ANALYZER; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION FUNCTION; CREATINE KINASE BLOOD LEVEL; DNA DAMAGE; ENZYME BLOOD LEVEL; EPIDERMIS CELL; FEMALE; FOLLOW UP; HUMAN; HYPERLIPIDEMIA; IMMUNOASSAY; LIVER CELL; MALE; MUSCLE ATROPHY; MUSCLE CELL; MUSCLE STIFFNESS; MUSCLE WEAKNESS; MYALGIA; OXIDATIVE STRESS; PRIORITY JOURNAL; SPECTROPHOTOMETRY; XEROSIS;

ADOLESCENT; ADULT; ANTIOXIDANTS; DEOXYGUANOSINE; DERMATOLOGIC AGENTS; DNA DAMAGE; FEMALE; HUMANS; ISOTRETINOIN; LIVER; MALE; MUSCLE, SKELETAL; MUSCULAR DISEASES; OXIDATIVE STRESS;

EID: 27744492668     PISSN: 14346621     EISSN: 14346621     Source Type: Journal    
DOI: 10.1515/CCLM.2005.204     Document Type: Article

References (33)

1. Physician's Desk Reference, 53rd ed. Montvale, NJ: Medical Economics, 1999.
2. Honein MA, Paulozzi LJ, Eriskson ED. Continued occurrence of Accutane-exposed pregnancies. Teratology 2001; 54:142-7.
3. Lammer EJ, Chen DT, Hoar RM, Agnish ND, Benke BJ, Braun GT, et al. Retinoic acid and embryopathy. N Engl J Med 1985;313:837-41.
4. Willhite CC, Lovey A, Eckhoff C. Distribution, teratogenicity and embryonic delivery dose of retinoid Ro 23-9223. Toxicol Appl Pharmacol 2000;164:171-5.
5. Akamatsu H, Horio T, Hattori K. Increased hydrogen peroxide generation by neutrophils from patients with acne inflammation. Int J Dermatol 2003;42:566-9.
6. Yaki K. Lipid peroxides and related radicals in clinical medicine. In: Armstrong D, editor. Free radicals in diagnostic medicine. New York: Plenum Press, 1994:1-14.
7. Richter C, Park JW, Ames BN. Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc Natl Acad Sci USA 1988;85:6565-7.
8. Kasai H, Crain PF, Kuchino Y, Nishimura S, Otsuyama A, Tonooka H. Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair. Carcinogenesis 1986;7:1849-51.
9. Kasai H, Nishimura S, Kurokawa Y, Hayashi Y. Oral administration of the renal carcinogen, potassium bromate, specifically produces 8-hydroxydeoxyguanosine in rat target organ DNA. Carcinogenesis 1987;8:1959-61.
10. Yin B, Whyatt RM, Perera FP, Randal MC, Cooper TB, Santella RM. Determination of 8-hydroxydeoxyguanosine by an immunoaffinity chromatography-monoclonal antibody based ELISA. Free Radic Biol Med 1995;18: 1023-32.
11. Mills C, Marks R. Adverse reactions to oral retinoids. Drug Saf 1993;9:280-90.
12. Katz RA, Jorgensen H, Nigra T. Elevation of serum triglyceride levels from oral isotretinoin in disorders of keratinization. Arch Dermatol 1980;116:1369-72.
13. Mecocci P, Fano G, Fulle S, MacGarvey U, Shinobu L, Polidori MC, et al. Age-dependent increases in oxidative damage to DNA, lipids, and proteins in human skeletal muscle. Free Radic Med 1999;26:303-8.
14. Miller MJ, Rice-Evans C, Davies MJ, Copinathan V, Milner A. A novel method for measuring antioxidant capacity and its application to monitoring the antioxidant status in premature neonates. Clin Sci (Lond) 1993; 84:407-12.
15. Strube M, Haenen GR, Van den Berg H, Bast A. Pitfalls in a method for assessment of total antioxidant capacity. Free Radic Res 1997;26:515-21.
16. Inoue T, Inoue K, Maeda H, Takayanagi K, Morrooka S. Immunological response to oxidized LDL occurs in association with oxidative DNA damage independently of serum LDL concentrations in dyslipidemic patients. Clin Chim Acta 2000;305:115-21.
17. Hallwell B, Gutteridge JM. Free radical in biology and medicine, 2nd ed. Oxford, UK: Clarendon Press, 1989: 110-9.
18. Kanofsky JR, Hoogland H, Wever R, Weiss SJ. Singlet oxygen production by human eosinophils. J Biol Chem 1988;263:9692-6.
19. Gotz ME, Kunig G, Riederer P, Youdim MB. Oxidative stress: free radical production in neural regeneration. Pharmacol Ther 1994;63:37-122.
20. Beckman B, Ames BW. Oxidative decay of DNA. J Biol Chem 1997;272:19633-6.
21. Lonardo F, Dragnev KH, Freemantle SJ, Ma Y, Memoli N, Sekula D, et al. Evidence for the epidermal growth factor receptor as a target for lung cancer prevention. Cancer Res 2002;8:54-60.
22. Georgala S, Schulpis KH, Georgala C, Michas T. L-Carnitine supplementation in patients with cystic acne on isotretinoin therapy. J Eur Acad Dermatol Venereol 1999;13:205-9.
23. Ichiba M, Maeta Y, Mukoyama T, Saeki T, Yasui S, Kanbe T, et al. Expression of 8-hydroxy-2′-deoxyguanosine in Chronic liver disease and hepatocellular carcinoma. Liver Int 2003;23:338-45.
24. Dragnev K, Stover D, Dmitrovsky E. Lung cancer prevention. Chest 2003;123:60S-71S.
25. Magneldorf D, Umesomo OK, Evans RM. The retinoid receptors. In: Sporn MB, Roberts AB, Goodman DS, editors. The retinoids: biology, chemistry and medicine. New York: Raven Press, 1994:319-49.
26. Glass CK, Rose DW, Rosenfeld MG. Nuclear receptor coactivators. Curr Opin Cell Biol 1997;9:222-32.
27. Zhang XK, Lehmann J, Hoffmann B, Dawson MI, Cameron J, Graupner G, et al. Homodimer formation of retinoid X receptor induced by 9-cis-retinoic acid. Nature 1992;358:587-91.
28. Langenfeld J, Kiyokawa H, Sekula D, Boyle J, Dmitrovsky E. Posttranslational regulation of cyclin D1 by retinoid acid: chemoprevention mechanism. Proc Natl Acad Sci USA 1997;94:12070-4.
29. Boyle JO, Langenfeld J, Lonardo F, Sekula D, Reczek P, Rusch V, et al. Cyclin D1 proteolysis: a retinoid chemoprevention signal in normal, immortalized, and transformed human bronchial epithelial cells. J Natl Cancer Inst 1999;91:373-9.
30. Rowling MJ, McMulley MH, Schalinske KL. Vitamin A and its derivatives induce hepatic glycine-N-methyl-tranferase and hypomethylation of DNA in rats. J Nutr 2002;132:365-9.
31. Hoffman RM. Altered methoinine metabolism DNA, methylation and oncogene expression in carcinogenesis. A review and synthesis. Biochim Biophys Acta 1984;738:49-87.
32. Hoffman RM. Unbalanced transmethelation and the perturbation of the differentiated state leading to cancer. BioEssays 1990;12:163-6.
33. Schulpis KH, Karikas GA, Georgala S, Michas T, Tsakiris S. Elevated plasma homocysteine levels in patients on isotretinoin therapy for cystic acne. Int J Dermatol 2001; 40:33-6.