Rapamycin: A new string to the antiproteinuric bow?

Journal of the American Society of Nephrology

Volumn 16, Issue 7, 2005, Pages 1878-1879

  Brunskill, Nigel J ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

RAPAMYCIN; IMMUNOSUPPRESSIVE AGENT;

DISEASE ASSOCIATION; DRUG EFFICACY; EDITORIAL; FIBROSIS; GRAFT REJECTION; HEYMANN NEPHRITIS; HUMAN; INFLAMMATION; KIDNEY DISEASE; MEDICAL LITERATURE; NONHUMAN; PRIORITY JOURNAL; PROTEINURIA; NOTE;

HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY DISEASES; PROTEINURIA; SIROLIMUS;

EID: 27744489523     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1681/ASN.2005050504     Document Type: Editorial

References (16)

1. Wilmer WA, Rovin BH, Hebert CJ, Rao SV, Kumor K, Hebert LA: Management of glomerular proteinuria: A commentary. J Am Soc Nephrol 14: 3217-3232, 2003
2. Ruggenenti P, Schieppati A, Remuzzi G. Progression, remission, regression of chronic renal diseases. Lancet 357: 1601-1608, 2001
3. El Nahas AM, Bello AK. Chronic kidney disease: The global challenge. Lancet 365: 331-340, 2005
4. Schieppati A, Remuzzi G: Proteinuria and its consequences in renal disease. Acta Paediatr Suppl 92: 9-13, 2003
5. Wang Y, Wang YP, Tay YC, Harris DC: Progressive adriamycin nephropathy in mice: Sequence of histologic and immunohistochemical events. Kidney Int 58: 1797-1804, 2000
6. Remuzzi G: The nephropathic nature of proteinuria. Curr Opin Nephrol Hyperten 8: 655-663, 1999
7. Harris KPG, Lefkowith JB, Schreiner GF: Essential fatty acid deficiency ameliorates acute renal dysfunction in the rat after the administration of aminonucleoside of puromycin. J Clin Invest 86: 1115-1123, 1990
8. Wetzels JFM, Gerlag PGG, Sluiter HE, Hoitsma AJ, Koene RAP: Prednisone induced fluctuations of proteinuria in patients with a nephrotic syndrome. Nephron 44: 344-350, 1986
9. Garcia DL, Rennke HG, Brenner BM, Anderson S: Chronic glucocorticoid therapy amplifies glomerular injury in rats with renal ablation. J Clin Invest 80: 867-874, 1987
10. de Haij S, Daha MR, van Kooten C: Mechanism of steroid action in renal epithelial cells. Kidney Int 65: 1577-1588, 2004
11. Bonegio RGB, Fuhro R, Wang Z, Valeri R, Andry C, Salant D, Lieberthal W. Rapamycin ameliorates proteinuria-associated tubulointerstitial inflammation and fibrosis in experimental membranous nephropathy. J Am Soc Nephrol 16: 2063-2072, 2005
12. Dixon R, Brunskill NJ: Activation of mitogenic pathways by albumin in kidney proximal tubule epithelial Cells: Implications for the pathophysiology of proteinuric states. J Am Soc Nephrol 10: 1487-1497, 1999
13. Pallet N, Thervet E, Le Corre D, Knebelmann B, Nusbaum P, Tomkiewicz C, Meria P, Flinois JP, Beaune P, Legendre C, Anglicheau D: Rapamycin inhibits human renal epithelial cell proliferation: Effect on cyclin D3 mRNA expression and stability. Kidney Int 67: 2422-2433, 2005
14. Thomas ME, Brunskill NJ, Harris KPG, Bailey E, Pringle JH, Furness P, Walls J: Proteinuria induces tubular cell turnover: A potential mechanism for tubular atrophy. Kidney Int 55: 890-898, 1999
15. Hebert LA, Agarwal G, Sedmak D, Mahan JD, Becker W, Nagaraja HN: Proximal tubular epithelial hyperplasia in patients with chronic glomerular proteinuria. Kidney Int 57: 1962-1967, 2000
16. Chen JK, Chen J, Neilson EG, Harris RC: Role of mammalian target of rapamycin signaling in compensatory renal growth. J Am Soc Nephrol 16: 1384-1391, 2005