Solubility of nicotinic acid in polyamidoamine dendrimer solutions

European Journal of Medicinal Chemistry

Volumn 40, Issue 12, 2005, Pages 1384-1389

  Yiyun, Cheng ^a   Tongwen, Xu ^a  

^a UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

Author keywords

Nicotinic acid; PAMAM; Polyamidoamine dendrimers; Solubility enhancer

Indexed keywords

DENDRIMER; ETHYLENEDIAMINE; NICOTINIC ACID; POLYAMIDE; POLYAMINE;

AQUEOUS SOLUTION; ARTICLE; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); DRUG SOLUBILITY; MOLECULAR SIZE; PH MEASUREMENT; ROOM TEMPERATURE; SURFACE PROPERTY;

DENDRIMERS; ETHYLENEDIAMINES; HYDROGEN-ION CONCENTRATION; MOLECULAR STRUCTURE; NIACIN; POLYAMINES; SOLUBILITY; SOLUTIONS; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PROPERTIES;

EID: 27744487918     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2005.08.001     Document Type: Article

References (15)

1. D.A. Tomalia, H. Baker, and J. Dewald A new class of polymers: starburst-dendritic macromolecules Polym. J. 17 1985 117
2. D.A. Tomalia, H. Baker, and J.R. Dewald Dendritic molecules: synthesis of starburst dendrimer Macromolecules 19 1986 2466
3. D.A. Tomalia, J.R. Dewald, (1986) Dense star polymers having two-dimensional molecular diameter. U.S. Patent 4587329.
4. D.A. Tomalia, A.M. Naylor, and W.A. Goddard Starburst dendrimers: molecular-level control of size, shape, surface chemistry, topology, and flexibility from atoms to macroscopic matter Angew. Chem. Int. Ed. Engl. 29 1990 138
5. E. Roseita, and D.A. Tomalia Poly (amidoamine) (PAMAM) dendrimers: from biomimicry to drug delivery and biomedical applications Drug Delivery Today 6 2001 427 436
6. O. Schiavon, G. Pasut, and S. Moro PEG-Ara-C conjugates for controlled release Eur. J. Med. Chem. 39 2004 123 133
7. M.F. Brana, G. Dominguez, and B. Saez Synthesis and anti-tumor activity of new dendritic polyamines-(imide-DNA-intercalator) conjugates: potent Lck inhibitors Eur. J. Med. Chem. 37 2002 541 551
8. P. Furuta, and J.M. Frechet Controlling solubility and modulating peripheral function in dendrimer encapsulated dyes J. Am. Chem. Soc. 125 2003 13173 13181
9. G.R. Newkome, C.N. Moorefield, and G.R. Baker Alkane cascade polymers processing micellar topology: micellanoic acid derivatives Angew. Chem. Int. Ed. Engl. 30 1991 1178 1180
10. C.T. Supuran, A. Scozzafava, and L. Menabuoni Carbonic anhydrase inhibitors - part 70. Synthesis and ocular pharmacology of a new class of water-soluble, topically effective intraocular pressure lowering agents derived from nicotinic acid and aromatic/heterocyclic sulfonamides Eur. J. Med. Chem. 34 1999 799 808
11. A.M. Naylor, I.I.I. Goddard, and D.A. Tomalia Starburst dendrimers 5: molecular shape control J. Am. Chem. Soc. 111 1989 2339 2341
12. W. Chen, D.A. Tomalia, and L.J. Thomas Unusual pH-dependent polarity changes in PAMAM dendrimers: Evidence for pH-responsive conformational changes Macromolecules 33 2000 9169 9172
13. S. Uppuluri, F.A. Morrison, and P.R. Dvornic Rheology of dendrimers. 2. Bulk polyamidoamine dendrimers under steady shear, creep, and dynamic oscillatory shear Macromolecules 33 2000 2551 2560
14. G. Postolis, A. Milliaris, and D. Tsiourvas Polyamidoamine dendrimers as pH-sensitive controlled release systems Chem. Eur. J. 5 1999 1440 1445
15. K. Chie, K. Kenji, and M. Kazuo Synthesis of polyamidoamine dendrimers having poly (ethylene glycol) grafts and their ability to encapsulate anticancer drugs Bioconjugate Chem. 17 2000 910 917