Degradation of poly-L/DL-lactide versus TCP composite pins: A three-year animal study

Journal of Biomedical Materials Research - Part B Applied Biomaterials

Volumn 75, Issue 2, 2005, Pages 304-310

  Prokop, Axel ^a,b   Höfl, Andreas ^c   Hellmich, Martin ^a   Jubel, Axel ^a,b   Andermahr, Jonas ^a,b   Rehm, Klaus Emil ^a,b   Hahn, Ulrich ^a,b  

^a UNIVERSITY OF COLOGNE   (Germany)

^b FH Bonn Rhein Sieg ^*  (Germany)

^c Eduardus Krankenhaus   (Germany)

Author keywords

Biodegradable pins; Biodegradation; Calcium phosphate; Composite; Polylactic acid

Indexed keywords

BIODIVERSITY; BIOTECHNOLOGY; BONE; CALCIUM COMPOUNDS; CARBOXYLIC ACIDS; COMPOSITE MATERIALS; IMPLANTS (SURGICAL);

BIODEGRADABLE PINS; CALCIUM PHOSPHATE; COMPOSITE; POLYLACTIC ACID;

BIODEGRADATION;

CALCIUM PHOSPHATE; POLYLACTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCOMPATIBILITY; BIODEGRADABLE IMPLANT; BIODEGRADATION; COMPOSITE MATERIAL; CONTROLLED STUDY; DEVICE; FEMUR CONDYLE; FOREIGN BODY REACTION; FRACTURE HEALING; HISTOLOGY; NONHUMAN; OSTEOLYSIS; OSTEOTOMY; SCAR FORMATION; SHEEP;

ANIMALS; BIOCOMPATIBLE MATERIALS; CALCIUM PHOSPHATES; KNEE JOINT; KNEE PROSTHESIS; MODELS, ANIMAL; POLYESTERS; SHEEP; TIME FACTORS;

EID: 27744477536     PISSN: 00219304     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbm.b.30300     Document Type: Article

References (29)

1. Ambrose CG, Clanton TO. Bioabsorbable implants: Review of clinical experience in orthopedic surgery. Ann Biomed Eng 2004;32:171-177
2. Rokkanen PU, Böstman O, Hirvensalo E, Mäkelä EA, Partio EK, Pätiälä H, Vainionpää SI, Vihtonen K, Törmälä P. Bioabsorbable fixation in orthopaedic surgery and traumatology. Bio-materials 2000;21:2607-2613.
3. Simon JA, Ricci JL, Di Cesari PE. Bioresorbable fracture fixation in orthopedics: a comprehensive review. Am J Orthop 1997;11:754-762.
4. Weiler A, Hoffmann R, Stähelin AC, Helling HJ, Südkamp NP. Synthetic biodegradable implants in operative sports medicine. Current concept review. Arthroscopy 2000;16:305-321.
5. Pihlajamäki HK, Karjalainen PT, Aronen HJ, Böstman OM. MR imaging of biodegradable polyevolactide osteosynthesis devices in the ankle. J Orthop Trauma 1997;11:559-564.
6. Tuompo P, Partio EK, Jukkula-Partio HPK, Hirvensalo E, Rokkanen P. Causes of the clinical tissue response to polyglycolide and polylactide implants with an emphasis on the knee. Arch Orthop Trauma Surg 2001;121:261-264.
7. Hoffmann R, Weiler A, Helling HJ, Krettek C, Rehm KE. Local foreign-body reactions to biodegradable implants-A classification system. Unfallchirurg 1997;100:658-666.
8. Prokop A, Jubel A, Helling HJ, Eibach T, Peters C, Baldus SE, Rehm KE. Soft tissue reactions of different biodegradable polylactide implants. Biomaterials 2004;25:259-267.
9. Weiler A, Helling HJ, Kirch U, Zirbes TK, Rehm KE. Foreign-body reaction and the course of osteolysis after polyglycolide implants for fracture fixation. J Bone Joint Surg 1996;78B:369-376.
10. Böstman O, Hirvensalo E, Mäkinen J, Rokkanen P. Foreign-body reactions to fracture fixation implants of biodegradable synthetic polymers. J Bone Joint Surg 1990;72B:592-596.
11. Casteleyn PP, Handelberg F, Haentjes P. Biodegradable rods versus Kirschner wire fixation of wrist fractures: a randomised trial. J Bone Joint Surg 1992;74B:858-861.
12. Rehm KE, Helling HJ, Gatzka C. New developments in the application of biodegradable implants. Orthopaede 1997;26: 489-497.
13. Claes LE, Ignatius AA, Rehm KE, Scholz C. New bioresorbable pin for the reduction of small bony fragments: design, mechanical properties and in vitro degradation. Biomaterials 1996;17: 1621-1626.
14. Ignatius AA., Claes LE. In-vitro biocompatibility of bioresorbable polymers. Poly (L,DL-lactide) and poly (L-lactide-co-glycolide). Biomaterials 1996;17:831-839.
15. Ignatius AA, Augat P, Claes LE. Degradation behavior of composite pins made of tricalcium phosphate and poly(L,DL-lactide) for the reduction of small bony fragments. J Biomat Sci Polym Ed 2001;12:185-194.
16. Claes L, Burri C, Kiefer H, Mutschler W. Resorbierbare Implantate zur Refixierung von osteochondralen Fragmenten in Gelenkflächen. Akt Traumatol 1986;16:74-77.
17. Pistner H, Gutwald R, Ordung R, Reuther J, Mühling J. Poly(L-lactide): a long-term degradation study in vivo. Part I: Biological results. Biomaterials 1993;14:671-677.
18. Pistner H, Bendix DR, Mühling J, Reuther JF. Poly(L-lactide): a long-term degradation study in vivo. Part III: analytical characterization. Biomaterials 1993;14:291-298.
19. Pistner H, Gutwald R, Schwartz G, Mühling J, Reuther J. Complete biodegradation of injection-molded polylactide internal fixation materials in hard and soft tissues in vivo. A long-term investigation up to 36 months. In: Claes L, Ignatius AA, editors. Hefte zu Der Unfallchirurg, Heft 265. Berlin: Springer; 1997. p 133-145.
20. Gogolewski S. Bioresorbable polymers in trauma and bone surgery. Int J Care Injured 2000;31S:D28-D32.
21. Athanasiou KA, Niederauer GG, Agrawal CM. Sterilization, toxicity, biocompatibility and clinical applications of polylactic acid/polglycolic acid copolymers. Biomaterials 1996;17:93-102.
22. Böstman OM, Pihlajamaki HK. Adverse tissue reactions to bioabsorbable fixation devices. Clin Orthop 2000;221:216-227.
23. Ciccone WJ, Motz C, Bentley C, Tasto JP. Bioabsorbable implants in orthopaedics: New developments and clinical applications. J Am Acad Orthop Surg 2001;9:280-288.
24. Park TG. Degradation of poly(lactic-co-glycolic acid) microspheres: effect of copolymer degradation. Biomaterials 1995; 16:1123-1130.
25. Vert M, Li M, Spenlehauer G, Guerin P. Bioresorbability and biocompatibility of aliphatic polyesters. J Mater Sci Med 1992; 3:432-446.
26. Furukawa T, Matsusue Y, Yasungaga T, Nakagawa Y, Okada Y, Shikinami Y, Okuno M, Nakamura T. Histomorphometric study on high-strength hydoxyapatite/poly (L-lactide) composite rods for internal fixation of bone fractures. J Biomed Mater Res 2000;50:410-419.
27. Furukawa T, Matsusue Y, Yasungaga T, Nakagawa Y, Shikinami Y, Okuno M, Nakamura T. Bone bonding ability of a new biodegradable composite for internal fixation of bone fractures. Clin Orthop 2000;379:247-258.
28. Ishii S, Tamura J, Nakamura T, Matsusue Y, Shikinami Y. Okunu M. Long-term study of high-strength hydoxyapatite/poly(L-lactide) composite rods for the internal fixation of bone fractures: a 2-4-year follow-up study in rabbits. J Biomed Mater Res 2003;66B:539-547.
29. Lewandrowski KU, Shrikar PB, Shea M, Untch CM, Hayes WC, Hile DC, Trantolo DJ. Composite resorbable polymer/hydroxylapatite composite screws for fixation of osteochondral osteotomies. Biomed Mater Eng 2002;12:423-438.