Synthesis and in vivo pharmacology of new derivatives of isothiazolo[5,4-b]pyridine of Mannich base type

Farmaco

Volumn 56, Issue 12, 2001, Pages 905-918

  Malinka, Wieslaw ^a   Karczmarzyk, Zbigniew ^b   Sieklucka Dziuba, Maria ^c   Sadowski, Miroslaw ^c   Kleinrok, Zdzislaw ^c  

^a WROCLAW MEDICAL UNIVERSITY   (Poland)

^b SIEDLCE UNIVERSITY OF NATURAL SCIENCES AND HUMANITIES   (Poland)

^c MEDICAL UNIVERSITY OF LUBLIN   (Poland)

Author keywords

3 Oxoisothiazolo 5,4 b pyridines; Analgesic activity; Mannich bases

Indexed keywords

PIPERAZINE DERIVATIVE; PYRIDINE DERIVATIVE; TETRAHYDROISOQUINOLINE; ANALGESIC AGENT; ISOTHIAZOLO(5,4 B)PYRIDINE; ISOTHIAZOLO(5,4-B)PYRIDINE; SEROTONIN RECEPTOR AFFECTING AGENT; THIAZOLE DERIVATIVE;

ANALGESIC ACTIVITY; ARTICLE; CENTRAL NERVOUS SYSTEM; DRUG CONFORMATION; DRUG SCREENING; DRUG SYNTHESIS; IN VIVO STUDY; LIPOPHILICITY; MOLECULAR MODEL; MOUSE; NONHUMAN; RAT; X RAY; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; INTRAPERITONEAL DRUG ADMINISTRATION; MOTOR ACTIVITY; PAIN; STRUCTURE ACTIVITY RELATION; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ANALGESICS, NON-NARCOTIC; ANIMALS; CRYSTALLOGRAPHY, X-RAY; DRUG EVALUATION, PRECLINICAL; INJECTIONS, INTRAPERITONEAL; MICE; MOLECULAR STRUCTURE; MOTOR ACTIVITY; PAIN; PYRIDINES; RATS; SEROTONIN AGENTS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 0035664106     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-827X(01)01157-0     Document Type: Article

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