Association between severity of type A hepatitis and nucleotide variations in the 5′ non-translated region of hepatitis A virus RNA: Strains from fulminant hepatitis have fewer nucleotide substitutions

Gut

Volumn 51, Issue 1, 2002, Pages 82-88

  Fujiwara, K ^a,g   Yokosuka, O ^a   Ehata, T ^a   Saisho, H ^a   Saotome, N ^b   Suzuki, K ^c   Okita, K ^d   Kiyosawa, K ^e   Omata, M ^f  

^a CHIBA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Department of Internal Medicine   (Japan)

^c IWATE MEDICAL UNIVERSITY   (Japan)

^d YAMAGUCHI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^f UNIVERSITY OF TOKYO   (Japan)

^g Kawatetsu Chiba Hospital   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEOTIDE; VIRUS RNA;

ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; GENE AMPLIFICATION; GENE SEQUENCE; HEPATITIS A; HEPATITIS A VIRUS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RIBOSOME; RNA TRANSLATION; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; VIRUS GENOME;

5' UNTRANSLATED REGIONS; ACUTE DISEASE; BASE SEQUENCE; DNA, COMPLEMENTARY; DNA, VIRAL; HEPATITIS A; HEPATITIS A VIRUS, HUMAN; HUMANS; MOLECULAR SEQUENCE DATA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, VIRAL; SEQUENCE ANALYSIS, DNA;

EID: 0036298227     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.51.1.82     Document Type: Article

References (33)

1. Current epidemiological trends of viral hepatitis in northern Europe
2. Acute non-A-E hepatitis in the United States and the role of hepatitis G virus infection
3. Fulminant and subfulminant hepatitis in Japan
4. Complete nucleotide sequence of wild-type hepatitis A virus: Comparison with different strains of hepatitis A virus and other picorna viruses
5. Genetic relatedness of hepatitis A virus strains recovered from different geographic regions
6. Epidemiologic patterns of wild-type hepatitis A virus determined by genetic variation
7. Complete nucleotide sequence of a cell culture-adapted variant of hepatitis A virus: Comparison with wild-type of a neutralization-resistant antigenic variant of hepatitis A virus
8. The 5′ nontranslated region of hepatitis A virus RNA: Secondary structure and elements required for translation in vitro
9. In vitro characterization of an internal ribosomal entry site (IRES) present within the 5′ nontranslated region of hepatitis A virus RNA: Comparison with the IRES of encephalomyocarditis virus
10. Low efficiency of the 5′ nontranslated region of hepatitis A virus RNA in directing cap-independent translation in permissive monkey kidney cells
11. 5′ UTR of hepatitis A virus RNA: Mutations in the 5′-most pyrimidine-rich tract reduce its ability to direct internal initiation of translation
12. A hepatitis A virus deletion mutant which lacks the first pyrimidine-rich tract of the 5′ nontranslated RNA remains virulent in primates after direct intrahepatic nucleic acid transfection
13. Mutations within the 5′ nontranslated region of hepatitis A virus RNA which enhance replication in BS-C cells
14. Temperature-sensitive hepatitis A virus mutants with deletions downstream of the first pyrimidine-rich tract of the 5′ nontranslated RNA are impaired in RNA synthesis
15. Mutations within the 5′ nontranslated RNA of cell culture-adapted hepatitis A virus which enhance cap-independent translation in cultured African green monkey kidney cells
16. Frequent detection of hepatitis A viral RNA in serum during the early convalescent phase of acute hepatitis A
17. PCR-SSCP analysis of 5′ nontranslated region of hepatitis A viral RNA: Comparison with clinicopathological features of hepatitis A
18. Analysis of full-length hepatitis A virus genome in sera from patients with fulminant and self-limited acute type A hepatitis
19. Aetiology and prognosis of fulminant viral hepatitis in Japan: A multicentre study
20. Detection of hepatitis C virus RNA by a two-step polymerase chain reaction with two pairs of primers deduced from the 5′-noncoding region
21. Estimation of average number of nucleotide substitutions when the rate of substitution varies
22. Confidence limits on phylogenies: An approach using the bootstrap
23. Clinical and epidemiological study on factors of serious development of viral hepatitis type A
24. Serious hepatitis A: An analysis of patients hospitalized during an urban epidemic in the United States
25. Fulminant hepatitis associated with hepatitis A virus superinfection in patients with chronic hepatitis C
26. The recent increase of severe type A hepatitis in Chiba area
27. Complete nucleotide sequences of an attenuated hepatitis A virus: Comparison with wild-type virus
28. Mutational events in consecutive passages of hepatitis A virus strain GBM during cell culture adaptation
29. An infectious cDNA clone of a cytopathic hepatitis A virus: Genomic regions associated with rapid replication and cytopathic effect
30. Utilization of chimeras between human (HM-175) and simian (AGM-27) strains of hepatitis A virus to study the molecular basis of virulence
31. A cytopathic, apoptosis-inducing variant of hepatitis A virus