Caffeic acid phenyl ester in propolis is a strong inhibitor of matrix metalloproteinase-9 and invasion inhibitor: Isolation and identification

Clinica Chimica Acta

Volumn 362, Issue 1-2, 2005, Pages 57-64

  Jin, Un Ho ^a   Chung, Tae Wook ^a   Kang, Sung Koo ^a   Suh, Seok Jong ^a   Kim, June Ki ^a   Chung, Kang Hyun ^b   Gu, Yeun Hwa ^c   Suzuki, Ikukatsu ^c   Kim, Cheorl Ho ^a  

^a Dongguk University   (South Korea)

^b Seoul National University of Science and Technology   (South Korea)

^c SUZUKA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

Author keywords

Caffeic acid phenyl ester; Matrix metalloproteinase 9; Propolis; Zymography

Indexed keywords

ANTINEOPLASTIC AGENT; CAFFEIC ACID PHENYL ESTER; GELATINASE B; GELATINASE B INHIBITOR; GELATINASE INHIBITOR; HERBACEOUS AGENT; PROPOLIS; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CANCER INVASION; CONTROLLED STUDY; DRUG DETERMINATION; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; ENZYME INHIBITION; FAST ATOM BOMBARDMENT MASS SPECTROMETRY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IC 50; LIVER CELL; LIVER CELL CARCINOMA; LIVER CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; STRUCTURE ANALYSIS; TANDEM MASS SPECTROMETRY;

ANIMALS; CAFFEIC ACIDS; CELL MOVEMENT; CELL SURVIVAL; CELLS, CULTURED; HUMANS; LIVER NEOPLASMS; MATRIX METALLOPROTEINASE 9; MICE; MOLECULAR STRUCTURE; NEOPLASM INVASIVENESS; PROPOLIS;

ANIMALIA;

EID: 27744466146     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cccn.2005.05.009     Document Type: Article

References (26)

1. B. Hladon, W. Bylka, and M. Ellnain-Wojtaszek In vitro studies on the cytostatic activity of propolis extracts Arzneim-Forsch 30 1980 1847 1848
2. S.C. Lin, Y.H. Lin, C.F. Chen, C.Y. Chung, and S.H. Hsu The hepatoprotective and therapeutic effects of propolis ethanol extract on chronic alcohol-induced liver injuries Am J Chin Med 25 1997 325 332
3. S.C. Lin, C.Y. Chung, C.L. Chiang, and S.H. Hsu The influence of propolis ethanol extract on liver microsomal enzymes and glutathione after chronic alcohol administration Am J Chin Med 27 1999 83 93
4. H.F. Liao, Y.Y. Chen, and J.J. Liu Inhibitory effect of caffeic acid phenyl ester on angiogenesis, tumor invasion, and metastasis J Agric Food Chem 51 1999 7907 7912
5. K. Natarajan, B. Singh, T.R. Burke, D. Grunbeger, and B.B. Aggarwal Caffeic acid phenyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-κB Proc Natl Acad Sci U S A 93 1996 9090 9095
6. T.W. Chung, S.K. Moon, Y.C. Lee, J.G. Kim, J.H. Ko, and C.H. Kim Enhanced expression of matrix metalloproteinase-9 by hepatitis B virus infection in liver cells Arch Biochem Biophys 408 2002 147 154
7. T.W. Chung, Y.C. Lee, and C.H. Kim Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential FASEB J 18 10 2004 1123 1125
8. T.W. Chung, S.K. Moon, and Y.C. Chang Novel and therapeutic effect of caffeic acid and caffeic acid phenyl ester on hepatocarcinoma cells: complete regression of hepatoma growth and metastasis by dual mechanism FASEB J 18 14 2004 1670 1681
9. T.W. Chung, S.K. Moon, Y.C. Lee, J.G. Kim, J.H. Ko, and C.H. Kim Enhanced expression of matrix metalloproteinase-9 (MMP-9) by hepatitis B virus infection into liver cells Arch Biochem Biophys 408 2002 147 154
10. D.E. Kleiner, and W.G. Stetler-Stevenson Matrix metalloproteinases and metastasis Cancer Chemother Pharmacol 43 1999 42 51
11. B.P. Himelstein, R. Canete-Soler, E.J. Bernhard, D.W. Dilks, and R.L. Muschel Metalloproteinases in tumor progression: the contribution of MMP-9 Invasion Metastasis 14 1995 246 258
12. E.J. Bernhard, S.B. Gruber, and R.J. Muschel Direct evidence linking expression of matrix metalloproteinase 9 (92-kDa gelatinase/collagen ase) to the metastatic phenotype in transformed rat embryo cells Proc Natl Acad Sci U S A 91 1994 4293 4297
13. E. Kaegi Unconventional therapies for cancer: 2. Green tea. The task force on alternative therapies of the Canadian breast cancer research initiative Can Med Assoc J 158 1998 1033 1035
14. M. Demeule, M. Brossard, M. Page, D. Gingras, and R. Beliveau Matrix metalloproteinase inhibition by green tea catechins Biochim Biophys Acta 1478 2000 51 60
15. B. Etzenhouser, C. Hansch, S. Kapur, and C.D. Selassie Mechanism of toxicity of esters of caffeic and dihydrocaffeic acids Bioorg Med Chem 9 2001 199
16. J.K. Shim, D.W. Kim, and T.H. Chung Characterization of a cell line HFH-T2, producing viral particles, from primary human fetal hepatocytes infected with hepatitis B virus J Microbiol Biotechnol 11 2 2001 186 192
17. W. Raab, and F. Hogl The action of antifungal imidazole derivatives on rat liver mitochondria Mykosen 25 1982 431 438
18. Z.Z. Su, Lin D. Grunberger, and P.B. Fisher Growth suppression and toxicity induced by caffeic acid phenethyl ester (CAPE) in type 5 adenovirus-transformed rat embryo cells correlate directly with transformation progression Cancer Res 54 1994 1865 1870
19. R. Giurgea, M.A. Rusu, D. Coprean, H. Popescu, and C. Polinicencu Biochemical effects of standardized propolis extract (SPE) and of silymarin on the liver of ethyl alcohol intoxicated rats Agressologie 288 1987 831 832
20. J.C. Tonn, S. Kerkau, and A. Hanke Effect of synthetic matrixmetalloproteinase inhibitors on invasive capacity and proliferation of human malignant gliomas in vitro Int J Cancer 80 1999 764 772
21. M. Nardini, F. Leonardi, C. Scaccini, and F. Virgili Modulation of ceramide-induced NF-kappaB binding activity and apoptotic response by caffeic acid in U937 cells: comparison with other antioxidants Free Radic Biol Med 30 2001 722 733
22. J.R. MacDougall, and L.M. Matrisian Contributions of tumor and stromal matrix metalloproteinases to tumor progression, invasion and metastasis Cancer Metastasis Rev 14 1995 351 362
23. J. Nemunaitis, C. Poole, and J. Primrose Combined analysis of studies of the effects of the matrix metalloproteinase inhibitor marimastat on serum tumor markers in advanced cancer: selection of a biologically active and tolerable dose for longer-term studies Clin Cancer Res 4 1998 1101 1109
24. X. Jiang, and Y. Zhen Cinnamamide, an antitumor agent with low cytotoxicity acting on matrix metalloproteinase Anti-Cancer Drugs 11 2000 49 54
25. K. Frenkel, H. Wei, and R. Bhimani Inhibition of tumor promoter-mediated processes in mouse skin and bovine lens by caffeic acid phenethyl ester Cancer Res 53 1993 1255 1261
26. P. Michaluart, J.L. Masferrer, and A. Carothers Inhibitory effects of caffeic acid phenethyl ester on the activity and expression of cyclooxygenase-2 in human oral epithelial cells and in a rat model of inflammation Cancer Res 59 1999 2347 2352