Exposure to ELF magnetic field tuned to Zn inhibits growth of cancer cells

Bioelectromagnetics

Volumn 26, Issue 8, 2005, Pages 631-638

  Sarimov, Ruslan ^a,b   Markova, Eva ^a,c   Johansson, Fredrick ^a   Jenssen, Dag ^a   Belyaev, Igor ^a,b  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b PROKHOROV GENERAL PHYSICS INSTITUTE   (Russian Federation)

^c CANCER RESEARCH INSTITUTE   (Slovakia)

Author keywords

Cyclotron frequency; Ion paramagnetic resonance; Magnetic paramagnetic resonance; p53

Indexed keywords

CANCER CELLS; CELL CULTURE; CELL DEATH; DISEASES; LANTHANUM COMPOUNDS; PARAMAGNETISM;

CANCER CELLS; CYCLOTRON FREQUENCY; GROWTH INHIBITION; ION PARAMAGNETIC RESONANCE; MAGNETIC PARAMAGNETIC RESONANCE; P53; PARAMETRIC RESONANCE; RESONANCE MODEL; STATIC MAGNETIC FIELDS; ZN 2+;

CELL PROLIFERATION;

ANTINEOPLASTIC AGENT; P53 REACTIVATION AND INDUCTION OF MASSIVE APOPTOSIS; PROTEIN P53; UNCLASSIFIED DRUG; ZINC;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER GROWTH; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; EXTREMELY LOW MAGNETIC FIELD; FIBROBLAST; GAMMA RADIATION; HELA CELL; HUMAN; HUMAN CELL; MAGNETIC FIELD; MAGNETIC PARAMETRIC RESONANCE; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL;

EID: 27744460276     PISSN: 01978462     EISSN: None     Source Type: Journal    
DOI: 10.1002/bem.20146     Document Type: Article

References (37)

1. Adey WR. 1999. Cell and molecular biology associated with radiation fields of mobile telephones. In: Stone WR, Ueno S, editors. Review of Radio Science, 1996-1999. Oxford: Oxford University Press, pp 845-872.
2. Alipov YD, Belyaev IY. 1996. Difference in frequency spectrum of extremely-low-frequency effects on the genome conformational state of AB 1157 and EMG2 E. coli cells. Bioelectromagnetics 17(5):384-387.
3. Baureus Koch CL, Sommarin M, Persson BR, Salford LG, Eberhardt JL. 2003. Interaction between weak low frequency magnetic fields and cell membranes. Bioelectromagnetics 24(6):395-402.
4. Belova NA, Lednev W. 2000. Dependence of gravitotropic reaction in segments of flax stems on frequency and amplitude of variable components of a weak combined magnetic field. Biofizika 45(6):1108-1111.
5. Belyaev IY, Alipov ED. 2001. Frequency-dependent effects of ELF magnetic field on chromatin conformation in Escherichia coli cells and human lymphocytes. Biochim Biophys Acta 1526(3):269-276.
6. Belyaev IY, Alipov ED, Harms-Ringdahl M. 1999. Effects of weak ELF on E. coli cells and human lymphocytes: Role of genetic, physiological and physical parameters. In: Bersani F editor. Electricity and magnetism in biology and medicine. NY: Kluwer Academic, pp 481-484.
7. Belyaev I, Torudd J, Harms-Ringdahl M. 2000. Effects of weak ELF on human lymphocytes; Munich, Germany. Frederick, MD, USA: The BEMS. pp 169-170.
8. Belyaev I, Alipov ED, Torudd J, Sarimov R, Harms-Ringdahl M. 2001; Effects of ELF on chromatin conformation and apoptosis in human lymphocytes; St. Paul, Minnesota, USA. Frederick, MD, USA: The BEMS. p 75.
9. Binhi VN. 2002. Magnetobiology: Underlying physical problems. San Diego: Academic Press.
10. Binhi VN, Alipov YD, Belyaev IY. 2001. Effect of static magnetic field on E. coli cells and individual rotations of ion-protein complexes. Bioelectromagnetics 22(2):79-86.
11. Blackman CF, Blanchard JP, Benane SG, House DE. 1994. Empirical test of an ion parametric resonance model for magnetic field interactions with PC-12 cells. Bioelectromagnetics 15(3):239-260.
12. Blackman CF, Blanchard JP, Benane SG, House DE, Elder JA. 1998. Double blind test of magnetic field effects on neurite outgrowth. Bioelectromagnetics 19(4):204-209.
13. Blanchard JP, Blackman CF. 1994. Clarification and application of an ion parametric resonance model for magnetic field interactions with biological systems. Bioelectromagnetics 15(3):217-238.
14. Brown JM, Wilson G. 2003. Apoptosis genes and resistance to cancer therapy: What does the experimental and clinical data tell us? Cancer Biol Ther 2(5):477-490.
15. Butler JS, Loh SN. 2003. Structure, function, and aggregation of the zinc-free form of the p53 DNA binding domain. Biochemistry 42(8):2396-2403.
16. Bykov VJ, Issaeva N, Selivanova G, Wiman KG. 2002a. Mutant p53-dependent growth suppression distinguishes PRIMA-1 from known anticancer drugs: A statistical analysis of information in the National Cancer Institute database. Carcinogenesis 23(12):2011-2018.
17. Bykov VJ, Issaeva N, Shilov A, Hultcrantz M, Pugacheva E, Chumakov P, Bergman J, Wiman KG, Selivanova G. 2002b. Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound. Nat Med 8(3):282-288.
18. Cho Y, Gorina S, Jeffrey PD, Pavletich NP. 1994. Crystal structure of a p53 tumor suppressor-DNA complex: Understanding tumorigenic mutations. Science 265(5170):346-355.
19. Coffer AI, Knowles PP. 1994. Divalent metal ions induce conformational change in pure, human wild-type p53 tumor suppressor protein. Biochim Biophys Acta 1209(2):279-285.
20. Coleman JE. 1992. Zinc proteins: Enzymes, storage proteins, transcription factors, and replication proteins. Annu Rev Biochem 61:897-946.
21. Engstrom S. 1996. Dynamic properties of Lednev's parametric resonance mechanism. Bioelectromagnetics 17(1):58-70.
22. Fuchs O, Babusiak M, Vyoral D, Petrak J. 2003. Role of zinc in eukaryotic cells, zinc transporters and zinc-containing proteins. Review article. Sb Lek 104(2):157-170.
23. Hainaut P, Milner J. 1993. A structural role for metal ions in the "wild-type" conformation of the tumor suppressor protein p53. Cancer Res 53(8):1739-1742.
24. Johansson F, Allkvist A, Erixon K, Malmvarn A, Nilsson R, Bergman A, Helleday T, Jenssen D. 2004. Screening for genotoxicity using the DRAG assay: Investigation of halogenated environmental contaminants. Mutat Res 563(1):35-47.
25. Laity JH, Lee BM, Wright PE. 2001. Zinc finger proteins: New insights into structural and functional diversity. Curr Opin Struct Biol 11(1):39-46.
26. Lednev VV. 1991. Possible mechanism for the influence of weak magnetic fields on biological systems. Bioelectromagnetics 12(2):71-75.
27. Lednev VV. 1996. Bioeffects of weak static and alternating magnetic fields. Biofizika 41(1):224-232.
28. McKeague AL, Wilson DJ, Nelson J. 2003. Staurosporine-induced apoptosis and hydrogen peroxide-induced necrosis in two human breast cell lines. Br J Cancer 88(1):125-131.
29. Meplan C, Richard MJ, Hainaut P. 2000. Metalloregulation of the tumor suppressor protein p53: Zinc mediates the renaturation of p53 after exposure to metal chelators in vitro and in intact cells. Oncogene 19(46):5227-5236.
30. Olsson G, Belyaev IY, Helleday T, Harms-Ringdahl M. 2001. ELF magnetic field affects proliferation of SPD8/V79 Chinese hamster cells but does not interact with intrachromosomal recombination. Mutat Res 493(1-2):55-66.
31. Simko M, Kriehuber R, Weiss DG, Loben RA. 1998. Effects of 50 Hz EMF exposure on micronucleus formation and apoptosis in transformed and nontransformed human cell lines. Bioelectromagnetics 19:85-91.
32. Smith SD, McLeod BR, Liboff AR, Cooksey K. 1987. Calcium cyclotron resonance and diatom mobility. Bioelectromagnetics 8(3):215-227.
33. Tofani S, Cintorino M, Barone D, Berardelli M, De Santi MM, Ferrara A, Orlassino R, Ossola P, Rolfo K, Ronchetto F, Tripodi SA, Tosi P. 2002. Increased mouse survival, tumor growth inhibition and decreased immunoreactive p53 after exposure to magnetic fields. Bioelectromagnetics 23(3):230-238.
34. Trillo MA, Ubeda A, Blanchard JP, House DE, Blackman CF. 1996. Magnetic fields at resonant conditions for the hydrogen ion affect neurite outgrowth in PC-12 cells: A test of the ion parametric resonance model. Bioelectromagnetics 17(1):10-20.
35. Verheyen GR, Pauwels G, Verschaeve L, Schoeters G. 2003. Effect of coexposure to 50 Hz magnetic fields and an aneugen on human lymphocytes, determined by the cytokinesis block micronucleus assay. Bioelectromagnetics 24(3):160-164.
36. Weber KJ, Wenz F. 2002. p53, apoptosis and radiosensitivity-Experimental and clinical data. Onkologie 25(2):136-141.
37. Williams CD, Markov MS, Hardman WE, Cameron IL. 2001. Therapeutic electromagnetic field effects on angiogenesis and tumor growth. Anticancer Res 21(6A):3887-3891.