Effects of locoweed on serum swainsonine and selected serum constituents in sheep during acute and subacute oral/intraruminal exposure

Journal of Animal Science

Volumn 83, Issue 2, 2005, Pages 466-477

  Obeidat, B S ^a   Strickland, J R ^b,e   Vogt, M L ^a   Taylor, J B ^c   Krehbiel, C R ^d   Remmenga, M D ^a   Clayshulte Ashley, A K ^a   Whittet, K M ^a   Hallford, D M ^a   Hernandez, J A ^a  

^a NEW MEXICO STATE UNIVERSITY   (United States)

^b AGRICULTURAL RESEARCH SERVICE   (United States)

^c USDA ARS US Sheep Experiment Station   (United States)

^d OKLAHOMA STATE UNIVERSITY   (United States)

^e NONE   (United Kingdom)

Author keywords

Acute Exposure; Locoweed; Sheep; Subacute Exposure; Swainsonine

Indexed keywords

ANIMALIA; OVIS ARIES;

EID: 27744458130     PISSN: 00218812     EISSN: None     Source Type: Journal    
DOI: 10.2527/2005.832466x     Document Type: Article

References (33)

1. Bachman, S. E., M. L. Galyean, G. S. Smith, D. M. Hallford, and J. D. Graham. 1992. Early aspects of locoweed toxicosis and evaluation of a mineral supplement or clinoptiloite as dietary supplement. J. Anim. Sci. 70:3125-3132.
2. Broquist, H. P. 1986. Livestock toxicosis, slobbers, locoism, and the indolizidine alkaloids. Nutr. Rev. 44:317-323.
3. Dorling, P. R., C. R. Huxtable, and S. M. Colegate. 1980. Inhibition of lysosomal α-mannosidase by swainsonine, an indolizidine alkaloid isolated from Swainsona canescens. Biochem. Soc. 191:649-651.
4. Elbein, A. D. 1989.The effects of plant indolizidine alkaloids and related compounds on glycoprotein processing. Page 155 in Swainsonine and Related Glycosidase Inhibitors. L. F. James, A. D. Elbein, R. J. Molyneux, and C. D. Warren, ed. Iowa State Univ. Press, Ames.
5. Galyean, M. L., M. H. Ralphs, M. N. Reif, J. D. Graham, and W. E. Braselton, Jr. 1996. Effects of previous grazing treatment and consumption of locoweed on liver mineral concentrations in beef steers. J. Anim. Sci. 74:827-833.
6. James, L. F., W. J. Hartley, D. Nielsen, S. Allen, and K. E. Panter. 1986. Locoweed (Oxytropis sericea) poisoning and congestive heart failure in cattle. J. Am. Vet. Med. Assoc. 189:1549-1556.
7. James, L. F., K. R. VanKampen, and W. J. Hartley. 1970. Comparative pathology of Astragalus (locoweed) and Swainsona poisoning in sheep. Path. Vet. 7:116-125.
8. Kaneko, J. J. 1997. Thyroid function. Pages 573-574 in Clinical Biochemistry of Domestic Animals. 5th ed. J. J. Kaneko, J. W. Harvey, and M. L. Bruss, ed. Academic Press, London, U.K.
9. Kramer, J. W., and W. E. Hoffmann. Chapter 12: Clinical Enzymology. Page 316 in Clinical Biochemistry of Domestic Animals. 5th ed. J. J. Kaneko, J. W. Harvey, and M. L. Bruss, ed. Academic Press, London, U.K.
10. Molyneux, R. J., and L. F. James. 1982. Loco intoxication: Indolizidine alkaloids of spotted locoweed (Astragalus lentignosus). Science 216:190-191.
11. Moore, J. E., and D. J. Undersander. 2002. Relative forage quality: An alternative to relative feed value and quality index. Pages 16-32 in Proc. Florida Rumin. Nutr. Symp. Univ. of Florida, Gainesville.
12. Nielsen, D. B., N. R. Rimbey, and L. F. James. 1988. Economic considerations of poisonous plants on livestock. Pages 5-15 in The ecology and economic impact of poisonous plants on livestock production. L. F. James, M. H. Ralphs, and D. B. Nielsen, ed. Westview Press, Inc., Boulder, CO.
13. NRC. 1985. Page 45 in Nutrient Requirements of Sheep. 6th rev. ed. Natl. Acad. Press, Washington, DC.
14. Panter, K. E., L. F. James, and W. J. Hartley. 1989. Transient testicular degeneration in rams fed locoweed (Astragalus lentiginosus). Vet. Human Toxicol. 31:42-46.
15. Plumlee, K. H., and F. D. Galey. 1994. Nurotoxic mycotoxins: A review of fungal toxins that cause neurological disease in large animals. J. Vet. Intern. Med. 8:49-54.
16. Pulsipher, G. D., M. L. Galyean, D. M. Hallford, G. S. Smith, and D. E. Kiehl. 1994. Effects of graded levels of bentonite on serum clinical profiles, metabolic hormones and serum swainsonine concentrations in lambs fed locoweed (Oxytropis sericea). J. Anim. Sci. 72:1561-1569.
17. Ralphs, M. H., L. V. Mickelsen, and D. L. Turner. 1987. Cattle grazing white locoweed: diet selection patterns of native and introduced cattle. J. Range Manage. 40:333-335.
18. Ralphs, M. H., K. E. Panter, and L. F. James. 1990. Feed preference and habituation of sheep poisoned by locoweed. J. Anim. Science. 68:1354-1362.
19. Ralphs, M. H., K. E. Panter, and L. F. James. 1991. Grazing behavior and forage preference of sheep with chronic locoweed toxicosis suggest no addiction. J Range Manage. 44:208-209.
20. Richards, J. B., D. M. Hallford, and G. C. Duff. 1999. Serum luteinizing hormone, testerone, and thyroxine and growth responses of ram lambs fed locoweed (Oxytropis sericea) and treated with vitamin E/selenium. Theriogenology 52:1055-1066.
21. Sharma, R. P., L. F. James, and R. J. Molyneux. 1984. Effect of repeated locoweed feeding on peripheral lymphocyte function and plasma proteins in sheep. Am. J. Vet. Res. 45:2090-2093.
22. Stegelmeier, B. L., L. F. James, K. E. Panter, D. R. Gardner, J. A. Pfister, M. H. Ralphs, and R. J. Molyneux. 1999. Dose response of sheep poisoned with locoweed (Oxytropis sericea). J. Vet. Diagn. Invest. 11:448-456.
23. Stegelmeier, B. L., L. F. James, K. E. Panter, D. R. Gardner, M. H. Ralphs, and J. A. Pfister. 1998. Tissue swainsonine clearance in sheep chronically poisoned with locoweed (Oxytropis sericea). J. Anim. Sci. 76:1140-1144.
24. Stegelmeier, B. L., L. F. James, K. E. Panter, and R. J. Molyneux. 1995. Serum swainsonine concentration and a-mannosidase activity in cattle and sheep ingesting Oxytropis sericea and Astragalus lentiginosus (locoweeds). Am. J. Vet. Res. 56:149-154.
25. Taylor, J. B., and J. R. Strickland. 2002. Appearance and disappearance of swainsonine in serum and milk of lactating ruminants with nursing young following a single dose exposure to swainsonine (locoweed; Oxytropis sericea). J. Anim. Sci. 80:2476-2484.
26. Taylor, J. B., J. R. Strickland, T. May, and D. E. Hawkins. 2000. Effect of subacute swainsonine (locoweed; Oxytropis sericea) consumption on immuno-competence and serum constituents of sheep in a nutrient-restricted state. Vet. Human Toxicol. 42:199-204.
27. Tulsiani, D. R. P., H. P. Broquist, L. F. James, and O. Touster. 1984. The similar effects of swainsonine and locoweed on tissue glycosidase and oligosaccharides of the pig indicate that the alkaloid is the principal toxin responsible for the induction of locoism. Arch. Biochem. Biophys. 232:76-85.
28. Tulsiani, D. R. P., H. P. Broquist, L. F. James, and O. Touster. 1988. Production of hybrid glycoproteins and accumulation of oligosaccharides in the brain of sheep and pigs administered swainsonine or locoweed. Arch. Biochem. Biophys. 264:607-617.
29. VanKampen, K. R., and L. F. James. 1969. Pathology of locoweed poisoning in sheep. Path. Vet. 6:413-423.
30. Vogt, M. L. 1999. Effects of swainsonine on serum swainsonine and selected ovine serum constituent levels during acute and subacute exposure. M. S. Thesis, New Mexico State Univ., Las Cruces.
31. Whittet, K. M., H. B. Encinias, J. R. Strickland, J. B. Taylor, J. D. Graham, A. K. Clayshulte, and A. M. Encinias. 2002. Effect of ionophore supplementation of selected serum constituents of sheep consuming locoweed. Vet. Human Toxicol. 44:136-140.
32. Wood, R. J., and O. Han. 1998. Recently identified molecular aspects of intestional iron absorption. J. Nutr. 128:1841-1844.
33. Yeo, T.-K., K.-T. Yeo, J. B. Parent, and K. Olden. 1985. Swainsonine treatment accelerates intracellular transport and secretion of glycoproteins in human hepatoma cells. J. Biol. Chemist. 260:2565-2569.