The lung at maximal exercise: Insights from comparative physiology

Clinics in Chest Medicine

Volumn 26, Issue 3, 2005, Pages 459-468

  Hopkins, Susan R ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIFFUSION; EXERCISE; HUMAN; HYPOXEMIA; LUNG CAPILLARY; LUNG EDEMA; LUNG FUNCTION; LUNG HEMORRHAGE; LUNG VENTILATION; LUNG VENTILATION PERFUSION RATIO; NONHUMAN; PRIORITY JOURNAL; REVIEW; SHUNT INFECTION; STRESS; LUNG; PATHOPHYSIOLOGY; PHYSIOLOGY; RESPIRATORY FUNCTION;

EXERCISE; HUMANS; LUNG; RESPIRATORY PHYSIOLOGY;

EID: 27744453919     PISSN: 02725231     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ccm.2005.05.003     Document Type: Review

References (77)

1. Academy of Achievement Interview: Sir Roger Bannister Available at: http://www.achievement.org/autodoc/page/banOint-3 Accessed July 6, 2005
2. J. Bryant 3:59.4 the quest to break the four minute mile 2005 Arrow Books, LTD London
3. An introduction to a general stud-book; containing (with few exceptions) the pedigree of every horse, mare & c. of note, that has appeared on the turf for the last fifty years with many of an earlier date 1791 J. Weatherby London
4. C.R. Taylor, R.H. Karas, and E.R. Weibel Adaptive variation in the mammalian respiratory system in relation to energetic demand Respir Physiol 69 1987 1 127
5. R.J. Rose, and D.L. Evans Cardiovascular and respiratory function in the athletic horse J.R. Gillespie N.E. Robinson Equine exercise physiology 2 1987 ICEEP Publications Davis (CA) 1 25
6. W.M. Bayly, D.A. Schultz, and D.R. Hodgson Ventilatory responses of the horse to exercise: effect of gas collection systems J Appl Physiol 63 1987 1210 1217
7. L.L. Couetil, F.S. Rosenthal, and C.M. Simpson Forced expiration: a test for airflow obstruction in horses J Appl Physiol 88 2000 1870 1879
8. D.E. Bebout, D. Storey, and J. Roca Effects of altitude acclimatization on pulmonary gas exchange during exercise J Appl Physiol 67 1989 2286 2295
9. S.R. Hopkins, A.S. Belzberg, and B.R. Wiggs Pulmonary transit time and diffusion limitation during heavy exercise in athletes Respir Physiol 103 1996 67 73
10. S.R. Hopkins, D.C. McKenzie, and R.B. Schoene Pulmonary gas exchange during exercise in athletes I: ventilation-perfusion mismatch and diffusion limitation J Appl Physiol 77 1994 912 917
11. B.M. Pluim, A.H. Zwinderman, and A. van der Laarse The athleteís heart: a meta-analysis of cardiac structure and function Circulation 101 2000 336 344
12. R. Coltrain, V. Kumar, and C. Robbins Diseases of the white cells, lymph nodes and spleen R. Coltrain V. Kumar C. Robbins Robbins pathological basis of disease 1989 Saunders Philadelphia 173 320
13. J.A. Dempsey, and P.D. Wagner Exercise-induced arterial hypoxemia J Appl Physiol 87 1999 1997 2006
14. 2 max J Appl Physiol 66 1989 2491 2495
15. C.A. Harms, S.R. McClaran, and G.A. Nickele Effect of exercise-induced arterial O2 desaturation on VO2max in women Med Sci Sports Exerc 32 2000 1101 1108
16. S.R. Hopkins, and C.A. Harms Gender and pulmonary gas exchange during exercise Exerc Sport Sci Rev 32 2004 50 56
17. W.M. Bayly, D. Schulz, and D. Hodgson Ventilatory response to exercise in horses with exercise-induced hypoxemia J.R. Gillespie N.E. Robinson Equine exercise physiology 2 1987 ICEEP Publications Davis (CA) 172 182
18. P.D. Wagner, J.R. Gillespie, and G.L. Landgren Mechanism of exercise-induced hypoxemia in horses J Appl Physiol 66 1989 1227 1233
19. C.M. Parks, and M. Manohar Blood-gas tensions and acid-base status in ponies during treadmill exercise Am J Vet Res 45 1984 15 19
20. J.A. Dempsey, P.G. Hanson, and K.S. Henderson Exercised-induced arterial hypoxaemia in healthy human subjects at sea level J Physiol (Lond) 355 1984 161 175
21. S.K. Powers, S. Dodd, and J. Lawler Incidence of exercise-induced hypoxemia in elite endurance athletes at sea level Eur J Appl Physiol 58 1988 298 302
22. C.A. Harms, S.R. McClaran, and G.A. Nickele Exercise-induced arterial hypoxaemia in healthy young women J Physiol (Lond) 507 pt. 2 1998 619 628
23. S.R. Hopkins, R.C. Barker, and T.D. Brutsaert Pulmonary gas exchange during exercise in women: effects of exercise type and work increment J Appl Physiol 89 2000 721 730
24. T.P. Gavin, and J.M. Stager The effects of exercise modality on exercise-induced hypoxemia Respir Physiol 115 1999 317 323
25. J. Mead Dysanapsis in normal lungs assessed by the relationship between maximal flow, static recoil, and vital capacity Am Rev Respir Dis 121 1980 339 342
26. W.M. Thurlbeck Postnatal human lung growth Thorax 37 1982 564 571
27. J.D. Schwartz, S.A. Katz, and R.W. Fegley Analysis of spirometric data from a national sample of healthy 6- to 24-year-olds (NHANES II) Am Rev Respir Dis 138 1988 1405 1414
28. S.R. Hopkins, W.M. Bayly, and R.F. Slocombe Effect of prolonged heavy exercise on pulmonary gas exchange in horses J Appl Physiol 84 1998 1723 1730
29. P.D. Wagner, J.R. Gillespie, and G.L. Landgren Mechanism of exercise-induced hypoxemia in horses J Appl Physiol 66 1989 1227 1233
30. A.J. Rice, A.T. Thornton, and C.J. Gore Pulmonary gas exchange during exercise in highly trained cyclists with arterial hypoxemia J Appl Physiol 87 1999 1802 1812
31. J. Piiper, and P. Scheid Gas transport efficacy of gills, lungs and skin: theory and experimental data Respir Physiol 23 1975 209 221
32. J. Piiper, and P. Scheid Models for a comparative functional analysis of gas exchange organs in vertebrates J Appl Physiol 53 1982 1321 1329
33. S.R. Hopkins, T.P. Gavin, and N.M. Siafakas Effect of prolonged, heavy exercise on pulmonary gas exchange in athletes J Appl Physiol 85 1998 1523 1532
34. J.R. Torre-Bueno, P.D. Wagner, and H.A. Saltzman Diffusion limitation in normal humans during exercise at sea level and simulated altitude J Appl Physiol 58 1985 989 995
35. M.D. Hammond, G.E. Gale, and K.S. Kapitan Pulmonary gas exchange in humans during exercise at sea level J Appl Physiol 60 1986 1590 1598
36. S.R. McClaran, C.A. Harms, and D.F. Pegelow Smaller lungs in women affect exercise hyperpnea J Appl Physiol 84 1998 1872 1881
37. S.K. Powers, D. Martin, and M. Cicale Exercise-induced hypoxemia in athletes: role of inadequate hyperventilation Eur J Appl Physiol 65 1992 37 42
38. C.A. Harms, and J.M. Stager Low chemoresponsiveness and inadequate hyperventilation contribute to exercise-induced hypoxemia J Appl Physiol 79 1995 575 580
39. S.H. Franklin, J.R. Naylor, and J.G. Lane Effect of dorsal displacement of the soft palate on ventilation and airflow during high-intensity exercise Equine Vet J Suppl 2002 379 383
40. D.P. Attenburrow Time relationship between the respiratory cycle and limb cycle in the horse Equine Vet J 14 1982 69 72
41. M.R. Bonsignore, G. Morici, and P. Abate Ventilation and entrainment of breathing during cycling and running in triathletes Med Sci Sports Exerc 30 2 1998 239 245
42. C.L. Lafortuna, F. Saibene, and M. Albertini The regulation of respiratory resistance in exercising horses Eur J Appl Physiol 90 2003 396 404
43. W. Bayly, H. Schott II, and R. Slocombe Ventilatory responses of horses to prolonged submaximal exercise Equine Vet J Suppl 18 1995 23 28
44. B.D. Johnson, K.W. Saupe, and J.A. Dempsey Mechanical constraints on exercise hyperpnea in endurance athletes J Appl Physiol 73 1992 874 886
45. B.S. Rasmussen, B. Hanel, and K. Jensen Decrease in pulmonary diffusion capacity after maximal exercise J Sports Sci 4 1984 185 188
46. B. Hanel, I. Teunissen, and A. Rabol Restricted postexercise pulmonary diffusion capacity and central blood volume depletion J Appl Physiol 83 1997 11 17
47. W. Schaffartzik, D.C. Poole, and T. Derion VA/Q distribution during heavy exercise and recovery in humans: implications for pulmonary edema J Appl Physiol 72 1992 1657 1667
48. A. Podolsky, M.W. Eldridge, and R.S. Richardson Exercise-induced VA/Q inequality in subjects with prior high-altitude pulmonary edema J Appl Physiol 81 1996 922 932
49. W. Schaffartzik, J. Arcos, and K. Tsukimoto Pulmonary interstitial edema in the pig after heavy exercise J Appl Physiol 75 1993 2535 2540
50. G.E. Gale, B.J. Torre, and R.E. Moon Ventilation-perfusion inequality in normal humans during exercise at sea level and simulated altitude J Appl Physiol 58 1985 978 988
51. P.D. Wagner, J.R. Sutton, and J.T. Reeves Operation Everest II: pulmonary gas exchange during a simulated ascent of Mt. Everest J Appl Physiol 63 1987 2348 2359
52. H.N. Hultgren Pulmonary hypertension and pulmonary edema J.A. Loeppsky M.L. Reidsel Oxygen transport to human tissues 1982 Elsevier/North Holland New York 243 254
53. K. Tsukimoto, J.P. Arcos, and W. Schaffartzik Effect of common dead space on VA/Q distribution in the dog J Appl Physiol 68 1990 2488 2493
54. P.A. Wilkins, R.D. Gleed, and N.M. Krivitski Extravascular lung water in the exercising horse J Appl Physiol 91 2001 2442 2450
55. L. Sosa Leon, D.R. Hodgson, and D.L. Evans Hyperhydration prior to moderate-intensity exercise causes arterial hypoxaemia Equine Vet J Suppl 34 2002 425 429
56. G. Manier, M. Duclos, and L. Arsac Distribution of lung density after strenuous, prolonged exercise J Appl Physiol 87 1999 83 89
57. J.D. Anholm, E.N. Milne, and P. Stark Radiographic evidence of interstitial pulmonary edema after exercise at altitude J Appl Physiol 86 1999 503 509
58. J.B. West, K. Tsukimoto, and O. Mathieu-Costello Stress failure in pulmonary capillaries J Appl Physiol 70 1991 1731 1742
59. J.B. West, and P.D. Wagner Pulmonary gas exchange J.B. West Bioengineering aspects of the lung 1977 Marcel Dekker New York 361 457
60. J.B. West, and O. Mathieu-Costello Strength of the pulmonary blood-gas barrier Respir Physiol 88 1992 141 148
61. J.B. West, and O. Mathieu-Costello Stress failure of pulmonary capillaries in the intensive care setting Schweiz Med Wochenschr 122 1992 751 757
62. J.B. West, and O. Mathieu-Costello Stress failure of pulmonary capillaries: role in lung and heart disease Lancet 340 1992 762 767
63. J.B. West, and C.O. Mathieu Vulnerability of pulmonary capillaries in heart disease Circulation 92 1995 622 631
64. J.B. West Invited review: pulmonary capillary stress failure J Appl Physiol 89 2000 2483 2489
65. Z. Fu, M.L. Costello, and K. Tsukimoto High lung volume increases stress failure in pulmonary capillaries J Appl Physiol 73 1992 123 133
66. K. Tsukimoto, O. Mathieu-Costello, and R. Prediletto Ultrastructural appearances of pulmonary capillaries at high transmural pressures J Appl Physiol 71 1991 573 582
67. K. Tsukimoto, N. Yoshimura, and M. Ichioka Protein, cell, and LTB4 concentrations of lung edema fluid produced by high capillary pressures in rabbit J Appl Physiol 76 1994 321 327
68. C.R. Sweeney, K.A. Humber, and K.A. Roby Cytologic findings of tracheobronchial aspirates from 66 thoroughbred racehorses Am J Vet Res 53 1992 1172 1175
69. J.B. West, C.O. Mathieu, and J.H. Jones Stress failure of pulmonary capillaries in racehorses with exercise-induced pulmonary hemorrhage J Appl Physiol 75 1993 1097 1109
70. M.W. O'Callaghan, J.R. Pascoe, and W.S. Tyler Exercise-induced pulmonary hemorrhage in the horse: Results of a detailed clinical, post mortem and imaging study. VIII. Conclusions and implications Equine Vet J 19 1987 428 434
71. J.H. Jones, B.L. Smith, and E.K. Birks Left atrial and pulmonary arterial pressures in exercising horses [abstract] FASEB J 6 1992 A2020
72. J.T. Reeves, B.M. Groves, and A. Cymerman Operation Everest II: cardiac filling pressures during cycle exercise at sea level Respir Physiol 80 1990 147 154
73. J.K. McKechnie, W.P. Leary, and T.D. Noakes Acute pulmonary oedema in two athletes during a 90-km running race S Afr Med J 56 1979 261 265
74. R.D. Weiler, A. Shupak, and I. Goldenberg Pulmonary oedema and haemoptysis induced by strenuous swimming BMJ 311 1995 361 362
75. J.B. West, O. Mathieu-Costello, and D.M. Geddes Intrapulmonary hemorrhage caused by stress failure of pulmonary capillaries during exercise [abstract] Am Rev Respir Dis 143 1991 A569
76. S.R. Hopkins, R.B. Schoene, and W.R. Henderson Intense exercise impairs the integrity of the pulmonary blood-gas barrier in elite athletes Am J Respir Crit Care Med 155 1997 1090 1094
77. S.R. Hopkins, R.B. Schoene, and W.R. Henderson Sustained submaximal exercise does not alter the integrity of the lung blood-gas barrier in elite athletes J Appl Physiol 84 1998 1185 1189