Pepducins: An effective means to inhibit GPCR signaling by neutrophils

Trends in Immunology

Volumn 26, Issue 12, 2005, Pages 619-621

  Lomas Neira, Joanne ^a   Ayala, Alfred ^a  

^a BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; G PROTEIN COUPLED RECEPTOR; PEPDUCIN DERIVATIVE; PEPTIDE DERIVATIVE; PROTEIN INHIBITOR; SB 455821; UNCLASSIFIED DRUG;

ALLOSTERISM; BLOOD CLOTTING; CALCIUM TRANSPORT; CELL ACTIVATION; CELL FUNCTION; CELL POPULATION; GENE SILENCING; HUMAN; IMMUNE RESPONSE; INFLAMMATION; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PROTEIN DOMAIN; PROTEIN TARGETING; SHORT SURVEY; SIGNAL TRANSDUCTION;

ANIMALS; CYTOKINES; HUMANS; INFLAMMATION; NEUTROPHILS; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

EID: 27744435269     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.it.2005.09.005     Document Type: Short Survey

References (21)

1. Matzer, S.P. et al. (2004) A synthetic, non-peptide CXCR2 antagonist blocks MIP-2-induced neutrophil migration in mice. Immunobiology 209, 225-233, 2-26
2. D.G. Souza Repertaxin, a novel inhibitor of rat CXCR2 function, inhibits inflammatory responses that follow intestinal ischaemia and reperfusion injury Brit. J. Pharmacol. 143 2004 132 142
3. V.C. Broaddus Neutralization of IL-8 inhibits neutrophil influx in a rabbit model of endotoxin-induced pleurisy J. Immunol. 152 1994 2960 2967
4. N. Fujisawa Inhibition of GROα-induced human endothelial cell proliferation by the α-chemokine inhibitor antileukinate Cytokine 11 1999 231 238
5. R. Bertini Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: prevention of reperfusion injury Proc. Natl. Acad. Sci. U.S.A. 101 2004 11791 11796
6. H. Echchannaoui CD14 deficiency leads to increased MIP-2 production, CXCR2 expression, neutrophil transmigration, and early death in pneumococcal infection J. Leukoc. Biol. 78 2005 706 715
7. J.A. Belperio Role of CXCR2/CXCR2 ligands in vascular remodeling during bronchiolitis obliterans syndrome J. Clin. Invest. 115 2005 1150 1162
8. T. Iyoda, and Y. Kobayashi Involvement of MIP-2 and CXCR2 in neutrophil infiltration following injection of late apoptotic cells into the peritoneal cavity Apoptosis 9 2004 485 493
9. J. Lomas-Neira In vivo gene silencing (with siRNA) of pulmonary expression of MIP-2 versus KC results in divergent effects on hemorrhage-induced, neutrophil-mediated septic acute lung injury J. Leukoc. Biol. 77 2005 846 853
10. N.M. Garcia Effect of inhibiting leukocyte integrin (CD18) and selectin (L-selectin) on susceptibility to infection with Pseudomonas aeruginosa J. Trauma 36 1994 714 719
11. N.C. Kaneider Reversing systemic inflammatory response syndrome with chemokine receptor pepducins Nat. Med. 11 2005 661 665
12. L. Covic Pepducin-based intervention of thrombin-receptor signaling and systemic platelet activation Nat. Med. 8 2002 1161 1165
13. L. Covic Activation and inhibition of G protein-coupled receptors by cell-penetrating membrane-tethered peptides Proc. Natl. Acad. Sci. U.S.A. 99 2002 643 648
14. A. Boire PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells Cell 120 2005 303 313
15. J.L. Lomas-Neira CXCR2 inhibition suppresses hemorrhage-induced priming for acute lung injury in mice J. Leukoc. Biol. 76 2004 1 7
16. J.L. Lomas Divergent roles of the murine neutrophil chemokines in hemorrhage induced priming for acute lung injury Cytokine 31 2005 169 179
17. W.W. Tang Intratracheal injection of endotoxin and cytokines. IX. Contribution of CD11a/ICAM-1 to neutrophil emigration Am. J. Physiol. 269 1995 L653 L659
18. E. Garcia-Ramallo Resident cell chemokine expression serves as the major mechanism for leukocyte recruitment during local inflammation J. Immunol. 169 2002 6467 6473
19. L.E. Rovai The murine neutrophil-chemoattractant chemokines LIX, KC and MIP-2 have distinct induction kinetics, tissue distributions, and tissue-specific sensitivities to glucocorticoid regulation in endotoxemia J. Leukoc. Biol. 64 1998 494 502
20. L.J. Quinton Selective transport of cytokine-induced neutrophil chemoattractant from the lung to the blood facilitates pulmonary neutrophil recruitment Am. J. Physiol. 286 2004 L465 L472
21. J.J. Stampfuss Inhibition of platelet thromboxane receptor function by a thrombin receptor-targeted pepducin Nat. Med. 9 2003 1447 1448