Investigation of the potentiation of the analgesic effects of fentanyl by ketamine in humans: A double-blinded, randomised, placebo controlled, crossover study of experimental pain[ISRCTN83088383]

BMC Anesthesiology

Volumn 5, Issue , 2005, Pages

  Tucker, Adam P ^a   Kim, Yong Ik ^b   Nadeson, Raymond ^c   Goodchild, Colin S ^c  

^a MONASH MEDICAL CENTRE   (Australia)

^b Soonchunhyang University College of Medicine   (South Korea)

^c MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

FENTANYL; KETAMINE; PLACEBO; PROPOFOL; SODIUM CHLORIDE;

ADULT; AGED; ANALGESIC ACTIVITY; ANTINOCICEPTION; ARTICLE; CARDIOVASCULAR PARAMETERS; CLINICAL LABORATORY; CLINICAL TRIAL; CONSCIOUSNESS DISORDER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG INFUSION; DRUG POTENTIATION; ELECTRIC CURRENT; HUMAN; HUMAN EXPERIMENT; LOW DRUG DOSE; NOCICEPTION; NORMAL HUMAN; PAIN; PRESSURE MEASUREMENT; PSYCHOMETRY; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT PARAMETERS; SEDATION; THERMAL STIMULATION; VALIDATION PROCESS; VOLUNTEER;

EID: 27644568268     PISSN: 14712253     EISSN: 14712253     Source Type: Journal    
DOI: 10.1186/1471-2253-5-2     Document Type: Article

References (59)

1. Stevens C: Aminoketones and methods for their production. DaC Parke USA: 1-6. Ref Type: Patent [3,254, 124], 31-5-1966
2. Clements JA, Nimmo WS: Pharmacokinetics and analgesic effect of ketamine in man. Br J Anaesth 1981, 53:27-30.
3. Hirota K, Lambert DG: Ketamine: its mechanism(s) of action and unusual clinical uses. Br J Anaesth 1996, 77:441-444.
4. Nishiyama T: Interaction between intrathecal morphine and glutamate receptor antagonists in formallin test. Eur J Pharmacol 2000, 395:203-210.
5. Joo G, Horvath G, Klimscha W, Kekesi G, Dobos I, Szikszay M, Benedek G: The effects of ketamine and its enantiomers on the morphine- or dexmedetomidine-induced antinociception after intrathecal administration in rats. Anesthesiology 2000, 93:231-241.
6. Plesan A, Hedman U, Xu XJ, Wiesenfeld-Hallin Z: Comparison of ketamine and dextromethorphan in potentiating the antinociceptive effect of morphine in rats. Anesth Analg 1998, 86:825-829.
7. Horvath G, Joo G, Dobos I, Klimscha W, Toth G, Benedek G: The synergistic antinociceptive interactions of endomorphin-I with dexmedetomidine and/or S(+)-ketamine in rats. Anesth Analg 2001, 93:1018-1024.
8. Chapman V, Dickenson AH: The combination of NMDA antagonism and morphine produces profound antinociception in the rat dorsal horn. Brain Res 1992, 573:321-323.
9. Yamamoto T, Yaksh TL: Studies on the spinal interaction of morphine and the NMDA antagonist MK-801 on the hyperesthesia observed in a rat model of sciatic mononeuropathy. Neurosci Lett 1992, 135:67-70.
10. Plummer GF: Improved method for the determination of propofol in blood by high-performance liquid chromatography with fluorescence detection. J Chromatogr 1987, 421:171-176.
11. Bjorkman S, Stanski DR: Simultaneous determination of fentanyl and alfentanil in rat tissues by capillary column gas chromatography. J Chromatogr 1988, 433:95-104.
12. Chernik DA, Gillings D, Laine H, Hendler J, Silver JM, Davidson AB, Schwam EM, Siegel JL: Validity and reliability of the Observer's Assessment of Alertness/Sedation Scale: study with intravenous midazolam. J Clin Psychopharmacol 1990, 10:244-251.
13. Pfeffer RI, Kurosaki TT, Harrah CH Jr, Chance JM, Bates D, Detels R, Filos S, Butzke C: A survey diagnostic tool for senile dementia. Am J Epidemiol 1981, 114:515-527.
14. Schmid RL, Sandler AN, Katz J: Use and efficacy of low-dose ketamine in the management of acute postoperative pain: a review of current techniques and outcomes. Pain 1999, 82:111-125.
15. Belozertseva IV, Dravolina OA, Neznanova ON, Danysz W, Bespalov AY: Antinociceptive activity of combination of morphine and NMDA receptor antagonists depends on the inter-injection interval. Eur J Pharmacol 2000, 396:77-83.
16. Kozela E, Danysz W, Popik P: Uncompetitive NMDA receptor antagonists potentiate morphine antinociception recorded from the tail but not from the hind paw in rats. Eur J Pharmacol 2001, 423:17-26.
17. Allen RM, Dykstra LA: The competitive NMDA receptor antagonist LY235959 modulates the progression of morphine tolerance in rats. Psychopharmacology (Berl) 1999, 142:209-214.
18. Gonzalez P, Cabello P, Germany A, Norris B, Contreras E: Decrease of tolerance to, and physical dependence on morphine by, glutamate receptor antagonists. Eur J Pharmacol 1997, 332:257-262.
19. Redwine KE, Trujillo KA: Effects of NMDA receptor antagonists on acute mu-opioid analgesia in the rat. Pharmacol Biochem Behav 2003, 76:361-372.
20. Hoffmann VL, Baker AK, Vercauteren MP, Adriaensen HF, Meert TF: Epidural ketamine potentiates epidural morphine but not fentanyl in acute nociception in rats. Eur J Pain 2003, 7:121-130.
21. Hoffmann VL, Vermeyen KM, Adriaensen HF, Meert TF: Effects of NMDA receptor antagonists on opioid-induced respiratory depression and acute antinociception in rats. Pharmacol Biochem Behav 2003, 74:933-941.
22. Baker AK, Hoffmann VL, Meert TF: Interactions of NMDA antagonists and an alpha 2 agonist with mu, delta and kappa opioids in an acute nociception assay. Acta Anaesthesiol Belg 2002, 53:203-212.
23. Baker AK, Hoffmann VL, Meert TF: Dextromethorphan and ketamine potentiate the antinociceptive effects of mu- but not delta- or kappa-opioid agonists in a mouse model of acute pain. Pharmacol Biochem Behav 2002, 74:73-86.
24. Plesan A, Hoffmann O, Xu XJ, Wiesenfeld-Hallin Z: Genetic differences in the antinociceptive effect of morphine and its potentiation by dextromethorphan in rats. Neurosci Lett 1999, 263:53-56.
25. Pelissier T, Laurido C, Kramer V, Hernandez A, Paeile C: Antinociceptive interactions of ketamine with morphine or methadone in mononeuropathic rats. Eur J Pharmacol 2003, 477:23-28.
26. Sethna NF, Liu M, Gracely R, Bennett GJ, Max MB: Analgesic and cognitive effects of intravenous ketamine-alfentanil combinations versus either drug alone after intradermal capsaicin in normal subjects. Anesth Analg 1998, 86:1250-1256.
27. Andersen OK, Felsby S, Nicolaisen L, Bjerring P, Jensen TS, Arendt-Nielsen L: The effect of Ketamine on stimulation of primary and secondary hyperalgesic areas induced by capsaicin - a double-blind, placebo-controlled, human experimental study. Pain 1996, 66:51-62.
28. Subramaniam K, Subramaniam B, Steinbrook RA: Ketamine as adjuvant analgesic to opioids: a quantitative and qualitative systematic review. Anesth Analg 2004, 99:482-95.
29. Krystal JH, Karper LP, Seibyl JP, Freeman GK, Delaney R, Bremner JD, Heninger GR, Bowers MB Jr, Charney DS: Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses. Arch Gen Psychiatry 1994, 51:199-214.
30. Sadove MS, Shulman M, Hatano S, Fevold N: Analgesic effects of ketamine administered in subdissociative doses. Anesth Analg 1971, 50:452-457.
31. Hagelin A, Lundberg D: Ketamine fro postoperative analgesia after upper abdominal surgery. Clin Ther 1981, 4:229-233.
32. Dich-Nielsen JO, Svendsen LB, Berthelsen P: Intramuscular low-dose ketamine versus pethidine for postoperative pain treatment after thoracic surgery. Acta Anaesthesiol Scand 1992, 36:583-587.
33. Clausen L, Sinclair DM, Van Hasselt CH: Intravenous ketamine for postoperative analgesia. S Afr Med J 1975, 49:1437-1440.
34. Dickenson AH: Combination therapy in analgesia; seeking synergy. Current Opinion in Anaesthesiology 1993, 6:861-865.
35. Aspinall RL, Mayor A: A prospective randomized controlled study of the efficacy of ketamine for postoperative pain relief in children after adenotonsillectomy. Paediatr Anaesth 2001, 11:333-336.
36. Gurnani A, Sharma PK, Rautela RS, Bhattacharya A: Analgesia for acute musculoskeletal trauma: low-dose subcutaneous infusion of ketamine. Anaesth Intensive Care 1996, 24:32-36.
37. Bhattacharya A, Gurnani A, Sharma PK, Sethi AK: Subcutaneous infusion of ketamine and morphine for relief of postoperative pain: a double-blind comparative study. Ann Acad Med Singapore 1994, 23:456-459.
38. Adriaenssens G, Vermeyen KM, Hoffmann VL, Mertens E, Adriaensen HF: Postoperative analgesia with i.v. patient-controlled morphine: effect of adding ketamine. Br J Anaesth 1999, 83:393-396.
39. Owen H, Reekie RM, Clements JA, Watson R, Nimmo WS: Analgesia from morphine and ketamine. A comparison of infusions of morphine and ketamine for postoperative analgesia. Anaesthesia 1987, 42:1051-1056.
40. Edwards ND, Fletcher A, Cole JR, Peacock JE: Combined infusions of morphine and ketamine for postoperative pain in elderly patients. Anaesthesia 1993, 48:124-127.
41. Stubhaug A, Breivik H, Eide PK, Kreunen M, Foss A: Mapping of punctuate hyperalgesia around a surgical incision demonstrates that ketamine is a powerful suppressor of central sensitization to pain following surgery. Acta Anaesthesiol Scand 1997, 41:1124-1132.
42. Jahangir SM, Islam F, Aziz L: Ketamine infusion for postoperative analgesia in asthmatics: a comparison with intermittent meperidine. Anesth Analg 1993, 76:45-49.
43. Kee WD, Khaw KS, Ma ML, Mainland PA, Gin T: Postoperative analgesic requirement after cesarean section: a comparison of anesthetic induction with ketamine or thiopental. Anesth Analg 1997, 85:1294-1298.
44. Javery KB, Ussery TW, Steger HG, Colclough GW: Comparison of morphine and morphine with ketamine for postoperative analgesia. Can J Anaesth 1996, 43:212-215.
45. Burstal R, Danjoux G, Hayes C, Lantry G: PCA ketamine and morphine after abdominal hysterectomy. Anaesth Intensive Care 2001, 29:246-251.
46. Reeves M, Lindholm DE, Myles PS, Fletcher H, Hunt JO: Adding ketamine to morphine for patient-controlled analgesia after major abdominal surgery: a double-blinded, randomized controlled trial. Anesth Analg 2001, 93:116-120.
47. Murdoch CJ, Crooks BA, Miller CD: Effect of the addition of ketamine to morphine in patient-controlled analgesia. Anaesthesia 2002, 57:484-488.
48. Unlugenc H, Ozalevli M. Guler T, Isik G: Postoperative pain management with intravenous patient-controlled morphine: comparison of the effect of adding magnesium or ketamine. Eur J Anaesthesiol 2003, 20:416-421.
49. Jaksch W, Lang S, Reichhalter P, Raab G, Dann K, Fitzal S: Perioperative small-dose S(+)-ketamine has no incremental beneficial effects on postoperative pain when standard-practice opioid infusions are used. Anesth Analg 2002, 94:981-6.
50. Guignard B, Coste C, Costes H, Sessler DI, Lebrault C, Morris W, Simonnet G, Chauvin M: Supplementing desflurane-remifentanil anesthesia with small-dose ketamine reduces perioperative opioid analgesic requirements. Anesth Analg 2002, 95:103-8.
51. Heinke W, Grimm D: [Preemptive effects caused by co-analgesia with ketamine in gynecological laparotomies?]. Anaesthesiol Reanim 1999, 24:60-64.
52. Guillou N, Tanguy M, Seguin P, Branger B, Campion JP, Malledant Y: The effects of small-dose ketamine on morphine consumption in surgical intensive care unit patients after major abdominal surgery. Anesth Analg 2003, 97:843-847.
53. Sator-Katzenschlager S, Deusch E, Maier P, Spacek A, Kress HG: The long-term antinociceptive effect of intrathecal S(+)-ketamine in a patient with established morphine tolerance. Anesth Analg 2001, 93:1032-4.
54. Kathirvel S, Sadhasivam S, Saxena A, Kannan TR, Ganjoo P: Effects of intrathecal ketamine added to bupivacaine for spinal anaesthesia. Anaesthesia 2000, 55:899-904.
55. Stotz M, Oehen HP, Gerber H: Histological findings after long-term infusion of intrathecal ketamine for chronic pain: a case report. J Pain Symptom Manage 1999, 18:223-228.
56. Hawksworth C, Serpell M: Intrathecal anesthesia with ketamine. Reg Anesth Pain Med 1998, 23:283-288.
57. Karpinski N, Dunn J, Hansen L, Masliah E: Subpial vacuolar myelopathy after intrathecal ketamine: report of a case. Pain 1997, 73:103-105.
58. Yang CY, Wong CS, Chang JY, Ho ST: Intrathecal ketamine reduces morphine requirements in patients with terminal cancer pain. Can J Anaesth 1996, 43:379-383.
59. Bion JF: Intrathecal ketamine for war surgery. A preliminary study under field conditions. Anaesthesia 1984, 39:1023-1028.