Comparison of Mycobacterium tuberculosis isocitrate dehydrogenases (ICD-1 and ICD-2) reveals differences in coenzyme affinity, oligomeric state, pH tolerance and phylogenetic affiliation

BMC Biochemistry

Volumn 6, Issue , 2005, Pages

  Banerjee, Sharmistha ^a   Nandyala, Ashok ^a   Podili, RaviPrasad ^a   Katoch, Vishwa Mohan ^b   Hasnain, Seyed E ^a,c  

^a CENTRE FOR DNA FINGERPRINTING AND DIAGNOSTICS   (India)

^b NATIONAL JALMA INSTITUTE FOR LEPROSY AND OTHER MYCOBACTERIAL DISEASES   (India)

^c JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ISOCITRATE DEHYDROGENASE; ISOCITRIC ACID; ISOENZYME; MAGNESIUM ION; METAL; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; OLIGOMER;

ACIDITY; ARTICLE; BINDING AFFINITY; BIOCHEMISTRY; COMPARATIVE STUDY; CONTROLLED STUDY; ENERGY; EUKARYOTE; GENETIC CODE; GROWTH CURVE; KINETICS; METABOLISM; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; OLIGOMERIZATION; OPEN READING FRAME; PH MEASUREMENT; PHYLOGENY; PHYSICAL CHEMISTRY; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; TEMPERATURE MEASUREMENT;

BACTERIAL PROTEINS; COENZYMES; HYDROGEN-ION CONCENTRATION; ISOCITRATE DEHYDROGENASE; MYCOBACTERIUM TUBERCULOSIS; PHYLOGENY;

BACTERIA (MICROORGANISMS); EUKARYOTA; MYCOBACTERIUM TUBERCULOSIS;

EID: 27644567666     PISSN: 14712091     EISSN: 14712091     Source Type: Journal    
DOI: 10.1186/1471-2091-6-20     Document Type: Article

References (29)

1. Holms H: Flux analysis: a basic tool of microbial physiology. Adv Microb Physiol 2001, 45:271-340.
2. Stryer L: Biochemistry. 4th edition. W. H. Freeman and Co., USA; 1995.
3. Kanao T, Kawamura M, Fukui T, Atomi H, Imanaka T: Characterization of isocitrate dehydrogenase from the green sulfur bacterium Chlorobium limicola, A carbon dioxide-fixing enzyme in the reductive tricarboxylic acid cycle. Eur J Biochem 2002, 269:1926-1931.
4. Muro-Pastor MI, Florencio FJ: Purification and properties of NADP-isocitrate dehydrogenase from the unicellular cyanobacterium Synechocystis sp. Eur J Biochem 1992, 203:99-105.
5. +-specific isocitrate dehydrogenase of Escherichia coli. I. Purification and characterization. Biochim Biophys Acta 1972, 258:27-39.
6. Vasquez B, Reeves HC: NADP-specific isocitrate dehydrogenase from Escherichia coli. V. Multiple forms of the enzyme. Biochim Biophys Acta 1981, 660:16-22.
7. Chen R, Yang H: A highly specific monomeric isocitrate dehydrogenase from Corynebacterium glutamicum. Arch Biochem Biophys 2000, 383:238-245.
8. Balamir A: NADP-linked isocitrate dehydrogenase from beef liver: a new method of purification and the effect of metal ion cofactor on its stability. Biochem Med 1983, 29:194-206.
9. Jennings GT, Minard KI, McAlister-Henn L: Expression and mutagenesis of mammalian cytosolic NADP+-specific isocitrate dehydrogenase. Biochemistry 1997, 36:13743-13747.
10. Soundar S, Danek BL, Colman RF: Identification by mutagenesis of arginines in the substrate binding site of the porcine NADP-dependent isocitrate dehydrogenase. J Biol Chem 2000, 275:5606-5612.
11. Dhariwal KR, Venkitasubramanian TA: NADP-specific isocitrate dehydrogenase of Mycobacterium phlei ATCC 354: purification and characterization. J Gen Microbiol 1987, 133:2457-2460.
12. Steen IH, Madern D, Karlstrom M, Lien T, Ladenstein R, Birkeland NK: Comparison of isocitrate dehydrogenase from three hyperthermophiles reveals differences in thermostability, cofactor specificity, oligomeric state, and phylogenetic affiliation. J Biol Chem 2001, 276:43924-43931.
13. Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, et al.: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 1998, 393:537-544.
14. Banerjee S, Nandyala A, Podili R, Katoch VM, Murthy KJ, Hasnain SE: Mycobacterium tuberculosis (Mtb) isocitrate dehydrogenases show strong B cell response and distinguish vaccinated controls from TB patients. Proc Natl Acad Sci USA 2004, 101:12652-12657.
15. Kornberg HL: The role and control of the glyoxylate cycle in Escherichia coli. Biochem J 1966, 99:1-11.
16. Singh SK, Miller SP, Dean A, Banaszak LJ, LaPorte DC: Bacillus subtilis Isocitrate Dehydrogenase. a substrate analogue for Escherichia coli isocitrate dehydrogenase kinase/phosphatase. J Biol Chem 2002, 277:7567-7573.
17. Holms WH: Control of flux through the citric acid cycle and the glyoxylate bypass in Escherichia coli. Biochem Soc Symp 1987, 54:17-31.
18. Holms H: Flux analysis and control of the central metabolic pathways in Escherichia coli. FEMS Microbiol Rev 1996, 19:85-116.
19. McKinney JD, Honer zu BK, Munoz-Elias EJ, Miczak A, Chen B, Chan WT, Swenson D, et al.: Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase. Nature 2000, 406:735-738.
20. Xu J, Gordon JI: Honor thy symbionts. Proc Natl Acad Sci USA 2003, 100:10452-10459.
21. Schnarrenberger C, Martin W: Evolution of the enzymes of the citric acid cycle and the glyoxylate cycle of higher plants. A case study of endosymbiotic gene transfer. Eur J Biochem 2002, 269:868-883.
22. Lorencz MG, Wackernagel W: Bacterial gene transfer by natural genetic transformation in the environment. Microbial Reviews 1994, 58:563-602.
23. Choudhary RK, Mukhopadhyay S, Chakhaiyar P, Sharma N, Murthy KJR, Katoch VM, Hasnain SE: PPE antigen Rv2430c of Mycobacterium tuberculosis induces a strong B-Cell response. Infection Immunity 2003, 71:6338-6343.
24. Chakhaiyar P, Nagalakshmi Y, Aruna B, Murthy KJR, Katoch VM, Hasnain SE: Regions of high antigenicity within the hypothetical PPE major polymorphic tandem repeat open-reading frame, Rv2608 show a differential humoral response and a low T cell response in various categories of patients with tuberculosis. J Infect Dis 2004, 190:1237-1244.
25. Chakhaiyar P, Hasnain SE: Defining the mandate of tuberculosis research in a postgenomic era. Med Princ Pract 2004, 13:177-184.
26. Chauhan R, Mande SC: Characterization of the Mycobacterium tuberculosis H37Rv alkyl hydroperoxidase AhpC points to the importance of ionic interactions in oligomerization and activity. Biochem J 2001, 354:209-215.
27. Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ: Basic local alignment search tool. J Mol Biol 1990, 215:403-410.
28. Clamp M, Cuff J, Searle SM, Barton GJ: The Jalview Java alignment editor. Bioinformatics 2004, 20:426-437.
29. Kumar S, Tamura K, Nei M: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment. Brief Bioinform 2004, 5:150-163.